6-(azacyclo-substitute) anthraquinone platinous chloride complex as well as preparation method and application thereof

A technology of anthraquinone platinum dichloride and nitrogen heterocycle, which is applied in the field of medicine, can solve the problems of poor targeting, high toxicity, and single biological activity, and achieve good anti-tumor activity and safety effects
CN103554188AActive Publication Date: 2014-02-05LIAONING UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LIAONING UNIVERSITY
Publication Date
2014-02-05

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Abstract

The invention discloses a 6-(azacyclo-substitute) anthraquinone platinous chloride complex as well as a preparation method and an application thereof. The 6-(azacyclo-substitute) anthraquinone platinous chloride complex disclosed by the invention has the structure of a formula I. The complex disclosed by the invention has good anti-tumor activity and security, and has great application values in treating lung cancer, liver cancer, leukemia, colon cancer and ovarian cancer in the medicine field.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a 6-(nitroheterocycle substituted) anthraquinone platinum dichloride complex capable of inhibiting tumor cell growth and having antitumor effects, and a preparation method and application thereof. Background technique

[0002] Anthraquinones are broad-spectrum anti-tumor drugs developed in the 1970s, among which doxorubicin (ADR), daunorubicin (DNR) and mitoxantrone (IDA) are their representative drugs, which are effective for the treatment of breast cancer. Cancer and other solid tumors and acute non-lymphocytic leukemia have good results, and are still commonly used anti-tumor drugs on the market. Among them, the anticancer activity of mitoxantrone is 5 times that of doxorubicin, and because it has no amino sugar structure, it has low cardiotoxicity, and has a better therapeutic effect on non-Hodgkin's disease lymphoma, leukemia, advanced breast cancer and other tumors. it ...

Claims

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