Folic acid-porous platinum-graphene oxide composite nano material as well as application thereof in detecting tumor cells

A graphene composite and nanomaterial technology, which is applied in the field of nanotechnology and medical testing, can solve problems such as difficult to achieve detection results, and achieve good peroxidase activity and rapid and sensitive detection effects
CN103558170AInactive Publication Date: 2014-02-05FUJIAN MEDICAL UNIV
4 Cites 20 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUJIAN MEDICAL UNIV
Publication Date
2014-02-05
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a folic acid-porous platinum-graphene oxide composite nano material as well as an application thereof in detecting tumor cells. The folic acid-porous platinum-graphene oxide composite nano material is prepared by the following steps: by taking graphene oxide as a substrate, carrying out amidation to crosslinked folic acid molecules; and carrying out in-situ synthesizing on platinum nano particles with porous structures. The folic acid-porous platinum-graphene oxide composite nano material can specifically identify a folate receptor on the surface of the cell, and meanwhile has a characteristic of simulating peroxidase and can catalyze hydrogen peroxide oxidized 3, 3', 5, 5'-tetramethyl benzidine hydrochloride to develop color. The number of the tumor cells can be quickly and agilely detected by means of chromogenic reaction, and 30 MCF-7 (Michigan Cancer Foundation-7) cells can be detected to the minimum extent. The material further can catalyze diaminobenzidine to generate a reddish brown precipitate on the surface of the cell so as to realize targeted positioning detection.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the preparation of folic acid-porous platinum-graphene oxide composite nanomaterials and a method for rapidly and sensitively detecting tumor cells, belonging to the fields of nanotechnology and medical testing. Background technique

[0002] Despite advances in medical technology, cancer remains the deadliest disease in the world. The traditional detection and localization of tumors is difficult to achieve the expected detection effect due to the lack of methods to achieve targeted localization. The development of new methods for early diagnosis of cancer is critical to successfully treating cancer and increasing patient survival.

[0003] Folic acid is a small molecular vitamin. Since scientists discovered in 1986 that folic acid enters cells through the receptor-mediated endocytic pathway, people have begun to conduct in-depth research on folic acid as a targeting carrier. It has been confirmed that folic acid receptors are...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More