Mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer and preparation method thereof

A mesoporous molecular sieve and surface imprinting technology, applied in molecular sieves and alkali exchange compounds, chemical instruments and methods, inorganic chemistry, etc., can solve problems such as deficiencies, and achieve the effects of large pore size, low preparation cost, and uniform pore diameter distribution.

Inactive Publication Date: 2014-02-12
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Technical problem to be solved: Aiming at the shortcomings of the current research methods on the in vivo metabolism of Scutellaria baicalensis and the shortcomings of traditional molecularly imprinted polymers, the present invention provides a molecularly imprinted polymer on the surface of mesoporous molecular sieves with specific recognition properties for baicalin and its preparation method

Method used

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  • Mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer and preparation method thereof
  • Mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer and preparation method thereof
  • Mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034](1).Add 2g (polyoxyethylene-polyoxypropylene-polyoxyethylene, PEO-PPO-PEO) triblock copolymer (referred to as P123) to 60g 2M hydrochloric acid and 15g deionized water at 40°C, stir and dissolve for 4 hours, The rotating speed is 500rpm; add 4.25g tetraethyl orthosilicate while stirring, continue to stir for 24h at 40°C, and the rotating speed is 1000rpm; let it stand in a polytetrafluoroethylene autoclave at 100°C for 24h; filter, dry at room temperature, and obtain the product in horse In the Furnace, the temperature was programmed to rise to 550°C at 5°C / min, and then fired at 550°C for 6 hours to obtain SBA-15 powder.

[0035] (2). Weigh 0.5g of the obtained SBA-15 powder and ultrasonically disperse it in 50mL of toluene solution, add 10mL of MPS, blow nitrogen gas for 10min, seal the mixed solution, rotate at 1000rpm, stir and reflux at 55°C for 24h to obtain the modified The finished SBA-15 was then ultrasonically washed with toluene and methanol, centrifuged to re...

Embodiment 2

[0040] (1).Add 2g (polyoxyethylene-polyoxypropylene-polyoxyethylene, PEO-PPO-PEO) triblock copolymer (referred to as P123) to 60g 2M hydrochloric acid and 15g deionized water at 40°C, stir and dissolve for 4 hours, The rotating speed is 500rpm; add 4.25g tetraethyl orthosilicate while stirring, continue to stir for 24h at 40°C, and the rotating speed is 1000rpm; let it stand in a polytetrafluoroethylene autoclave at 100°C for 24h; filter, dry at room temperature, and obtain the product in horse In the Furnace, the temperature was programmed to rise to 550°C at 5°C / min, and then fired at 550°C for 6 hours to obtain SBA-15 powder.

[0041] (2). Weigh 0.5g of the obtained SBA-15 powder and ultrasonically disperse it in 50mL of toluene solution, add 15mL of MPS, blow nitrogen gas for 10min, seal the mixed solution, rotate at 1000rpm, stir and reflux at 55°C for 24h to obtain the modified The finished SBA-15 was then ultrasonically washed with toluene and methanol, centrifuged to r...

Embodiment 3

[0046] (1).Add 2g (polyoxyethylene-polyoxypropylene-polyoxyethylene, PEO-PPO-PEO) triblock copolymer (referred to as P123) to 60g 2M hydrochloric acid and 15g deionized water at 40°C, stir and dissolve for 4 hours, The rotating speed is 500rpm; add 4.25g tetraethyl orthosilicate while stirring, continue to stir for 24h at 40°C, and the rotating speed is 1000rpm; let it stand in a polytetrafluoroethylene autoclave at 100°C for 24h; filter, dry at room temperature, and obtain the product in horse In the Furnace, the temperature was programmed to rise to 550°C at 5°C / min, and then fired at 550°C for 6 hours to obtain SBA-15 powder.

[0047] (2). Weigh 0.5g of the obtained SBA-15 powder and ultrasonically disperse it in 100mL of toluene solution, add 20mL of MPS, blow nitrogen gas for 10min, seal the mixture, rotate at 1000rpm, stir and reflux at 55°C for 24h to obtain the modified The finished SBA-15 was then ultrasonically washed with toluene and methanol, centrifuged to remove ...

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Abstract

The invention discloses a mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer and a preparation method thereof. The preparation method comprises the following steps: dispersing mesoporous molecular sieve SBA-15 powder into a methylbenzene solution in an ultrasonic mode, further adding methylacryloyl acyloxy propyl triethoxy silane so as to prepare a modified mesoporous molecular sieve SBA-15, further washing by using methylbenzene and methanol in sequence in the ultrasonic mode, centrifuging, and finally drying in vacuum for later use; adding template molecules and functional monomers into a pore-foaming agent, and dissolving in the ultrasonic mode to prepare a pre-assembled solution A; dispersing the modified mesoporous molecular sieve into the pore-foaming agent so as to obtain a solution B; mixing the solutions, further adding a cross-linking agent and an initiating agent, and raising the temperature to perform polymerization reaction; and after the reaction, centrifuging to remove the supernate, repeatedly washing a product by using a methanol-glacial acetic acid mixture solution in the ultrasonic mode, and further washing by using methanol to be neutral so as to obtain the mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer. Due to adoption of the polymer, high-efficient separation and purification of in-vivo baicalin are achieved.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymers, and in particular relates to a preparation method of a mesoporous molecular sieve SBA-15 composite nano surface imprinted polymer with specific recognition for baicalin. Background technique [0002] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family. It has a wide range of pharmacological effects such as anti-inflammatory, anti-viral, anti-allergic, anti-oxidant, and anti-tumor. It is one of the commonly used Chinese medicinal materials in my country. Since the 1930s, people have carried out a lot of research work on the chemical components and pharmacological effects of Scutellaria baicalensis single herb and its compound prescription, and the metabolic studies of chemical components in plasma, urine and feces have also been reported, mostly using LC- MS, GC-MS, HPCE-MS and other methods are used to qualitatively a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/56C08F220/06C08F226/02C08F226/06C08F2/44C08K9/06C08K3/34C01B39/00C08J9/28
Inventor 陈立娜何宏亮史丽英程清清高艳坤都述虎
Owner NANJING MEDICAL UNIV
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