Preparation method of polymer-bioglass hybrid material for bone repair

A bioglass and hybrid material technology, applied in medical science, prosthesis, etc., can solve the problems of lack of grafting bioactive molecules, difficulty in regulating cell behavior, etc., and achieve the effect of promoting proliferation and differentiation

Inactive Publication Date: 2014-03-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Traditional polymer-bioglass hybrid materials achieve biological activity by forming a hydroxyapatite layer on the surface of the material to achieve adhesion to cells. However, this type of material lacks the ability to graft bioactive molecules, making it difficult to achieve regulation. cell behavior

Method used

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  • Preparation method of polymer-bioglass hybrid material for bone repair
  • Preparation method of polymer-bioglass hybrid material for bone repair
  • Preparation method of polymer-bioglass hybrid material for bone repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Add a mixture of α-propargyl-ε-caprolactone and caprolactone to 3 g of polyethylene glycol 2000 with both terminal groups being hydroxyl groups (α-propargyl-ε-caprolactone and caprolactone The molar ratio is 1:5) 3mL, then add 50μL of 1mol / L stannous octoate and react at 140°C for 16h. After rotary evaporation, polycaprolactone-polyethylene glycol- Polycaprolactone triblock copolymer. Dissolve the above three-block copolymer in DMF, add 0.01 g of cuprous bromide after adding the azidized RGD at the end group, and obtain a three-block copolymer with RGD as the side chain. Add 1.482 g of isocyanate propyltriethoxysilane to the tri-block copolymer whose side chain is RGD, and react at 70° C. for 24 hours to obtain a tri-block copolymer whose terminal group is triethoxysilyl. Add 4.765g TEOS, 1.647g PH=3 hydrochloric acid aqueous solution, 2.1045g ethanol, 0.2778g TEP, 3.2413g calcium nitrate to the tri-block copolymer whose terminal group is triethoxysilyl group. After t...

Embodiment 2

[0039]Add a mixture of α-propargyl-ε-glycolide and glycolide to 6 g of polyethylene glycol 4000 with hydroxyl groups at both ends (α-propargyl-ε-glycolide and glycolide The molar ratio is 1:10) 12mL, then add 1mol / L stannous octoate 100μL and react at 120°C for 6h. After the reaction is completed, add 10-20mL of petroleum ether to wash, and obtain the propargyl functional group of polycaprolactone-polyethylene glycol-polycaprolactone triblock copolymer. The tri-block copolymer was dissolved in DMF, and 0.01 g of cuprous bromide was added after adding the azide-terminated RGD to obtain a tri-block copolymer whose side chain was RGD. Add 0.741 g of isocyanate propyltriethoxysilane to the tri-block copolymer, and react at 70° C. for 24 hours to obtain a tri-block copolymer whose terminal group is a triethoxysilyl group. Add 4.765g TEOS, 1.647g PH=3 hydrochloric acid aqueous solution, 0.2778g TEP, 3.2413g calcium nitrate to this polymer. Then add 0.2mL of 0.1mol / L hydrochloric a...

Embodiment 3

[0041] Add the mixed solution of α-propargyl lactide and lactide (the mol ratio of α-propargyl lactide and lactide is 10: 1) 1.5mL of the mixed solution, then add 30μL of 1mol / L stannous octoate, and react at 160°C for 16h. After the reaction is completed, add 10-20mL of petroleum ether to wash, and obtain the propargyl functional group after rotary evaporation Polylactic acid-polyethylene glycol-polylactic acid triblock copolymer. The functional polymer was dissolved in DMF, and 0.01 g of cuprous bromide was added after adding the azidized RGD at the end group to obtain a tri-block copolymer whose side chain was RGD. Add 0.741 g of isocyanate propyltriethoxysilane to the tri-block copolymer, and react at 60° C. for 24 hours to obtain a tri-block copolymer whose terminal group is a triethoxysilyl group. Add 4.765g TEOS, 1.647g PH=5 hydrochloric acid aqueous solution, 2.1045g ethanol, 0.2778g TEP, 3.2413g calcium nitrate to this polymer. Then add 0.2mL of 0.1mol / L hydrochlori...

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Abstract

The invention discloses a preparation method of a polymer-bioglass hybrid material for bone repair. The preparation method comprises the following steps: firstly mixing alkynyl-containing lactone with lactone, and carrying out ring opening polymerization under the initiation of polyethylene glycol so as to form polyester with alkynyl on a main chain; then reacting the polyester with alkynyl with azide modified molecules with biological activity so as to obtain polyester with biological activity; and finally carrying out hybridization on the polyester with biological activity and bioglass by using a sol-gel method so as to obtain the polymer-bioglass hybrid material for bone repair. The polymer-bioglass hybrid material is modified, so that the polymer-bioglass hybrid material has the molecules with biological activity, and finally specific functions for cells are realized.

Description

technical field [0001] The invention relates to the technical field of inorganic-organic composite materials, in particular to a preparation method of a polymer-biological glass hybrid material for bone repair. Background technique [0002] All over the world, bone defects caused by trauma, tumor and infection are afflicting many patients every year. Bone grafting has been used since the 19th century to repair large-scale bone defects by implanting autologous bone, allogeneic bone, and artificial bone. However, these materials have defects that cannot be ignored. These bone graft materials have limited sources, cause rejection, do not match the mechanical properties of the host bone, and have problems in service life, making it difficult to achieve a satisfactory bone repair effect. In this context, bone tissue engineering emerged as the times require. It uses isolated autologous high-concentration osteoblasts, bone marrow stromal stem cells, or chondrocytes to be planted ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/54C08G63/91C08G63/664
Inventor 吴刚柯晓天黄超
Owner SOUTH CHINA UNIV OF TECH
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