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Hollow magnetic polymer composite microsphere, and preparation method and application thereof

A technology of composite microspheres and polymers, which is applied in the field of hollow magnetic polymer composite microspheres and its preparation, can solve the problems of short shelf life of composite microspheres, reduction of saturation magnetization, and limitation of biomedical applications, so as to facilitate popularization application, high saturation magnetization, and the effect of improving magnetic response

Active Publication Date: 2014-04-16
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In previous reports, the magnetic nanoparticles in various obtained magnetic composite spheres are dispersed in the polymer material, and the degradation of the polymer material will lead to the collapse of the composite spheres, making the composite microspheres have a short shelf life. And to a certain extent, the reduction of saturation magnetization is increased
Moreover, in the existing preparation methods, a large amount of surfactants are used to stabilize the emulsification system, and the post-treatment is cumbersome, and the surfactants need to be completely cleaned, otherwise the residual surfactants will limit its further biomedical application

Method used

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  • Hollow magnetic polymer composite microsphere, and preparation method and application thereof
  • Hollow magnetic polymer composite microsphere, and preparation method and application thereof
  • Hollow magnetic polymer composite microsphere, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of Superparamagnetic Fe by Co-precipitation 3 o 4 nanoparticles

[0037] Add 100 mL of deionized water into a 250 mL flask, continuously blow nitrogen into the water to remove oxygen, and heat to 50°C, add 1000 mg of FeCl under stirring conditions 2 4H 2 O, 2448 mg FeCl 3 ·6H 2 O, 11 mg SDBS and 35 mL NH 4 OH, keep stirring under the protection of nitrogen and raise the temperature to 80°C, keep stirring for 1 h, cool to room temperature naturally, wash the precipitated black product with deionized water, and perform magnetic separation by applying an external magnetic field, discard the supernatant, The precipitate was washed with deionized water again, and magnetically separated by an external magnetic field, so that the pH was repeatedly washed to 7, at which time Fe 3 o 4 It can be well dispersed in water to form a stable suspension of superparamagnetic nanoparticles. Thermogravimetric analysis showed that the resulting Fe 3 o 4 Th...

Embodiment 2

[0039] Example 2 Preparation of Superparamagnetic Fe by Co-precipitation 2 o 3 nanoparticles

[0040] Add 100 mL of deionized water into a 250 mL flask and heat to 50°C, add 4000 mg of FeCl under stirring 3 ·6H 2 O, 5.5 mg SDBS and 35 mL NH 4 OH, keep stirring and raise the temperature to 80°C, keep stirring and react for 1 h, cool down to room temperature naturally, wash the precipitate with deionized water, and conduct magnetic separation by applying a magnetic field, discard the supernatant, and use the precipitate again The precipitate was washed with deionized water, and magnetically separated by an external magnetic field, and washed repeatedly until pH = 7, at this time Fe 2 o 3 It can be well dispersed in water to form a stable suspension of superparamagnetic nanoparticles. Thermogravimetric analysis showed that the resulting Fe 2 o 3 The content of SDBS is about 0.5%.

[0041] A series of superparamagnetic Fe with SDBS content of 0.5-2% was prepared by adju...

Embodiment 3

[0042] Example 3 Preparation of Hollow Magnetic Polymer Composite Microspheres

[0043] according to figure 2 For the procedure shown, 1 mL of CH containing 100 mg PLGA 2 Cl 2 The solution was added dropwise to the Fe prepared in 40 mL of Example 1. 3 o 4 In the suspension, Fe in the suspension 3 o 4 The concentration is 10 mg / mL, Fe 3 o 4 The content of SDBS in the medium is about 1%,; while adding dropwise, use a homogenizer to emulsify at 6500 rpm for 1 h, and then mechanically stir at room temperature at a speed of 800 rpm to make the solvent CH 2 Cl 2 Volatile. The obtained product was rinsed with deionized water and transferred to a centrifuge tube, centrifuged at 1500 rpm for 3 min, the supernatant was discarded, the precipitate was washed and centrifuged repeatedly, and washed and centrifuged repeatedly for 3 times. Finally, the synthesized PLGA / Fe 3 o 4 The composite microspheres are dispersed in water for later use.

[0044] The obtained composite mic...

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Abstract

The invention discloses a hollow magnetic polymer composite microsphere. The hollow magnetic polymer composite microsphere sequentially comprises an inner cavity, a polymer inner shell and a superparamagnetic nano-particle outer shell from inside to outside, and a large number of superparamagnetic nano-particles are tightly packed to form the superparamagnetic nano-particle outer shell. The composite microsphere is normalized in shape and narrow in size distribution, has high saturation magnetization, and is long in storage time and beneficial to popularization and application in the biomedicine field. The composite microsphere is synthesized by improved O / W emulsified solvents through a volatilization method, the superparamagnetic nano-particles serve as reactants to participate in the reaction and also serve as particle emulgators to stabilize the emulsification system, use of a large number of surface active agents is avoided, and the hollow magnetic polymer composite microsphere is easy to operate and convenient to popularize.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a hollow magnetic polymer composite microsphere, a preparation method and application thereof. technical background [0002] Magnetic polymer composite spheres with hollow structures have attracted much attention in recent years because of their unique properties. They can be widely used in biomedical fields, including drug delivery, protein separation, magnetic resonance imaging, etc. [0003] Hollow magnetic polymer composite spheres are usually prepared by nuclear template technology ( Chem. Commun. 2012, 48 , 3200-3202). Although this approach allows control of the thickness of the shell, it requires etching or calcining the core template of the precursor to create the hollow structure, a rather tedious synthetic step. Therefore, a series of strategies to prepare hollow magnetic composite spheres using template-free technology have been proposed: hollow superparamagnetic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/42C08J3/12B01J13/02
Inventor 吴尧蓝芳杨琦顾忠伟
Owner SICHUAN UNIV
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