Application of unilaterally-substituted phenyl urea compound

A compound, phenylurea technology, applied in the preparation and application of organic compounds, and the preparation of urea derivatives, etc., can solve the problems of low contact activity, single modified skeleton, and inability to completely change defects, etc.

Inactive Publication Date: 2014-04-30
CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

With the continuous expansion of the use time and scope of such agents, the shortcomings of low contact activity, slow action, and drug resistance have become increasingly prominent.
In order to overcome the defects of existing dihydrazide compounds, many units at home and abroad (such as Nankai University, Jiangsu Pesticide Research Institute, East China University of Science and Technology, China Agricultural University, Kyoto University,

Method used

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  • Application of unilaterally-substituted phenyl urea compound
  • Application of unilaterally-substituted phenyl urea compound
  • Application of unilaterally-substituted phenyl urea compound

Examples

Experimental program
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Embodiment Construction

[0011] Experimental test insects: armyworm (Mythimna separata Walker), cotton bollworm (Helicoverpa armigera), and corn borer (Ostrinia nubilalis Hubner) were collected from normal groups raised indoors, and the third-instar larvae with the same age, weight and physiological status were used for chemical activity screening test.

[0012] Experimental method: Refer to the requirements of the "Standard Operating Specification (SOP) for Determination of Pesticide Biological Activity" provided by the subject, using the leaf soaking method, using corn leaves to soak in the liquid medicine prepared with acetone (600ppm, 600mg / L), and wait for the liquid to dry Inject 3rd instar larvae, mainly for stomach poisoning and contact killing, and observe the feeding phenomenon of larvae at the same time. 72-hour check for mortality.

[0013] The criteria for judging the death are: lightly touch the insect body, and the individual pests that cannot crawl normally are regarded as dead indivi...

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Abstract

The invention discloses a unilaterally-substituted phenyl urea compound (as shown in formula I) and an application thereof. The structural formula of the compound is as shown in the formula I in description, wherein R1, R2 and R3 in the formula I represent hydrogen, C1-C4 alkyl, C1-C4 halo-alkyl, C1-C4 alkoxy, C1-C4 alkyl sulfenyl, halogen, nitryl, cyan and hydroxyl. The compound VS01 disclosed by the invention has an obvious ecdysone antagonistic activity on 20E and also has a certain killing activity on lepidopteron; the compound is simple in structure and large in modification space, and can be used for in-depth study as an ecdysone antagonist type lead compound with a totally new structure.

Description

technical field [0001] The invention relates to the application of a unilaterally substituted phenylurea compound in preventing and controlling agricultural pests. Background technique [0002] The mechanism of action of insect growth regulators (IGRs) is different from that of traditional insecticides. They have the advantages of high selectivity, safety to natural enemies and non-target organisms, and good environmental compatibility. They meet the needs of sustainable agricultural development and have broad application prospects. . At present, three types of IGRs have been successfully developed, including ecdysone analogs represented by dihydrazides, juvenile hormone analogs, and chitin synthesis inhibitors represented by benzoylureas. [0003] In the growth process of insects, ecdysone plays a very important regulatory role. It is a class of sterol compounds secreted by the insect prothymus, which can cause larvae to molt and promote metamorphosis. Due to the complex ...

Claims

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Application Information

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IPC IPC(8): C07C275/36C07C275/42C07C273/18A01N47/30A01P7/04
Inventor 张莉阴斌杨新玲
Owner CHINA AGRI UNIV
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