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Preparation method of thermosensitive composite gold nanoparticles

A nanoparticle and gold nanoparticle technology, applied in the field of nanomaterials, can solve the problems of poor shape regularity, high synthesis cost, and time-consuming modification steps of composite gold nanoparticles, and achieve easy mass production, rapid preparation, and low equipment requirements Effect

Active Publication Date: 2014-04-30
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Application Information

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Problems solved by technology

However, these methods have disadvantages such as high synthesis cost, high reaction temperature, time-consuming modification steps, and increased particle size after modification.
CN102286185A discloses a kind of attempt to use polyisopropylacrylamide grafted dextran polymer as nucleating agent and stabilizer to create a rapid preparation method of temperature-sensitive composite gold nanoparticles, but the prepared composite nanoparticle The shape of gold particles is poor and the size is not uniform, so it is difficult to be widely used

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  • Preparation method of thermosensitive composite gold nanoparticles

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preparation example Construction

[0018] In the preparation method of the present invention, the electrostatic adsorption between the active groups and the surface of the gold nanoparticles is used to realize the rapid preparation of temperature-sensitive composite gold nanoparticles. In particular, the temperature-sensitive characteristics of PNIPAM are used to adjust the temperature of the gold nano solution. The temperature realizes the moment when PNIPAM and gold nanoparticles are mixed from hydrophilic to hydrophobic, blocking the electrostatic adsorption reaction of other groups in the polymer with gold nanoparticles, thereby avoiding the agglomeration of gold nanoparticles.

[0019] In a more specific typical embodiment, the preparation method can be implemented according to the following steps:

[0020] (1) Preparation of gold nanoparticles

[0021] Configure 25-35 mL of 0.015-0.020% (W / V) HAuCl 4 Solution, and heat to boiling; add 0.5-2 mL of 1% (W / V) sodium citrate solution to boiling HAuCl 4 The solution i...

Embodiment 1

[0026] Example 1 The preparation method of temperature-sensitive composite gold nanoparticles, the specific steps are as follows:

[0027] (1) Preparation of gold nanoparticles: wash all containers with aqua regia, then rinse with deionized water; configure 25 mL of 0.020% (W / V) HAuCl 4 Solution and heat to boiling; add 1 mL of 1% (W / V) sodium citrate solution to boiling HAuCl 4 After the solution is heated for about 10 minutes, the heat source is removed. After the solution is cooled to room temperature in a natural state, gold nanoparticles are obtained with a particle size of about 10 nm.

[0028] (2) Preparation of temperature-sensitive composite gold nanoparticles: take 5 mL of the gold nanoparticle solution prepared in step (1), centrifuge to wash away free sodium citrate in the solution, and redisperse the gold nanoparticles obtained by centrifugation to 5 Add mL of deionized water and heat to 70 °C in a water bath, then configure 5 mL of 5.0% (W / V) amino-terminated PNIPAM s...

Embodiment 2

[0029] Example 2 The preparation method of temperature-sensitive composite gold nanoparticles, the specific steps are as follows:

[0030] (1) Preparation of gold nanoparticles: wash all containers with aqua regia, then rinse with deionized water; configure 29 mL of 0.020% (W / V) HAuCl 4 Solution and heat to boiling; add 1 mL of 1% (W / V) sodium citrate solution to boiling HAuCl 4 After the solution is heated for about 12 minutes, the heat source is removed. After the solution is cooled to room temperature in a natural state, gold nanoparticles are obtained with a particle size of about 12 nm.

[0031] (2) Preparation of temperature-sensitive composite gold nanoparticles: take 10 mL of the gold nanoparticle solution prepared in step (1), centrifuge to wash away free sodium citrate in the solution, and redisperse the gold nanoparticles obtained by centrifugation to 10 Add mL of deionized water and heat to 60 °C in a water bath, then configure 5 mL of 5.0% (W / V) amino-terminated PNIPAM...

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Abstract

The invention discloses a preparation method of thermosensitive composite gold nanoparticles, which comprises the steps of providing an aqueous dispersion of gold nanoparticles, heating to 50-70 DEG C, quickly adding into a thermosensitive polymer solution with an active group which can be combined with gold, and sufficiently mixing for reacting; after the mixed reaction solution is naturally cooled, separating out solid products therein, and cleaning to obtain the thermosensitive composite gold nanoparticles, wherein the gold nanoparticles are preferably the gold nanoparticles with surfaces modified by citric acid radicals, and the thermosensitive polymer with an active group which can be combined with gold is preferably the amino-terminated poly N-isopropylacrylamide (PNIPAM). The preparation method disclosed by the invention has the advantages of mild conditions and short reaction time, is simple and easy to implement, and is environment-friendly; moreover, the obtained product has relatively high yield, relatively good uniformity and good thermosensitivity, and can be widely applied to the fields such as biological optical sensing, medical fluorescence imaging and the like.

Description

technical field [0001] The invention relates to a rapid and environment-friendly preparation method of temperature-sensitive polymer / gold hybrid particles, belonging to the technical field of nanomaterials. Background technique [0002] Due to its obvious surface effect, volume effect, quantum effect, small size effect and macroscopic quantum tunneling effect, nanomaterials have many special properties that traditional materials do not have. Among them, gold nanoparticles have attracted great interest because of their good biocompatibility, special optical properties, and electrical properties. So far, nano-gold has become the nanomaterial with the most research vitality and development potential in nanotechnology, and has a wide range of applications in nanoelectronics, optoelectronics, catalysis and biomedicine. [0003] Due to the weak binding layer of charged ligands, the surface of gold nanoparticles can undergo non-covalent electrostatic adsorption with various charge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/24C08K3/08C08J3/00B82Y40/00
Inventor 肖清波蔺洪振冀月田肖志宏
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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