Preparation method of thermosensitive composite gold nanoparticles
A nanoparticle and gold nanoparticle technology, applied in the field of nanomaterials, can solve the problems of poor shape regularity, high synthesis cost, and time-consuming modification steps of composite gold nanoparticles, and achieve easy mass production, rapid preparation, and low equipment requirements Effect
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[0018] In the preparation method of the present invention, the electrostatic adsorption between the active groups and the surface of the gold nanoparticles is used to realize the rapid preparation of temperature-sensitive composite gold nanoparticles. In particular, the temperature-sensitive characteristics of PNIPAM are used to adjust the temperature of the gold nano solution. The temperature realizes the moment when PNIPAM and gold nanoparticles are mixed from hydrophilic to hydrophobic, blocking the electrostatic adsorption reaction of other groups in the polymer with gold nanoparticles, thereby avoiding the agglomeration of gold nanoparticles.
[0019] In a more specific typical embodiment, the preparation method can be implemented according to the following steps:
[0020] (1) Preparation of gold nanoparticles
[0021] Configure 25-35 mL of 0.015-0.020% (W / V) HAuCl 4 Solution, and heat to boiling; add 0.5-2 mL of 1% (W / V) sodium citrate solution to boiling HAuCl 4 The solution i...
Embodiment 1
[0026] Example 1 The preparation method of temperature-sensitive composite gold nanoparticles, the specific steps are as follows:
[0027] (1) Preparation of gold nanoparticles: wash all containers with aqua regia, then rinse with deionized water; configure 25 mL of 0.020% (W / V) HAuCl 4 Solution and heat to boiling; add 1 mL of 1% (W / V) sodium citrate solution to boiling HAuCl 4 After the solution is heated for about 10 minutes, the heat source is removed. After the solution is cooled to room temperature in a natural state, gold nanoparticles are obtained with a particle size of about 10 nm.
[0028] (2) Preparation of temperature-sensitive composite gold nanoparticles: take 5 mL of the gold nanoparticle solution prepared in step (1), centrifuge to wash away free sodium citrate in the solution, and redisperse the gold nanoparticles obtained by centrifugation to 5 Add mL of deionized water and heat to 70 °C in a water bath, then configure 5 mL of 5.0% (W / V) amino-terminated PNIPAM s...
Embodiment 2
[0029] Example 2 The preparation method of temperature-sensitive composite gold nanoparticles, the specific steps are as follows:
[0030] (1) Preparation of gold nanoparticles: wash all containers with aqua regia, then rinse with deionized water; configure 29 mL of 0.020% (W / V) HAuCl 4 Solution and heat to boiling; add 1 mL of 1% (W / V) sodium citrate solution to boiling HAuCl 4 After the solution is heated for about 12 minutes, the heat source is removed. After the solution is cooled to room temperature in a natural state, gold nanoparticles are obtained with a particle size of about 12 nm.
[0031] (2) Preparation of temperature-sensitive composite gold nanoparticles: take 10 mL of the gold nanoparticle solution prepared in step (1), centrifuge to wash away free sodium citrate in the solution, and redisperse the gold nanoparticles obtained by centrifugation to 10 Add mL of deionized water and heat to 60 °C in a water bath, then configure 5 mL of 5.0% (W / V) amino-terminated PNIPAM...
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