Hydrosulfate radical ion nanometer sensing material with up-conversion luminescence property and preparation method thereof

Abstract

The invention relates to a hydrosulfate radical ion nanometer sensing material with the up-conversion luminescence property, and a preparation method thereof. According to the invention,?a fluoride is adopted as a matrix and doped with trivalent rare earth ions to prepare a rare earth up-conversion luminescence nanometer crystal by using a solvothermal process; the rare earth up-conversion luminescence nanometer crystal is endowed with excellent water-solubility and biocompatibility through surface modification, the surface of the rare earth up-conversion luminescence nanometer crystal is modified by a mesoporous silicon dioxide layer, and an organic micromolecular probe responsive to hydrosulfate radical ions is prepared from a quaternary ammonium salt of an indole derivative and 4-(dimethylamino)benzaldehyde through Knoevenagel condensation; and the organic micromolecular probe is absorbed into the meso pore of silica on the surface of the rare earth up-conversion luminescence nanometer material through physical absorption. The organic-inorganic-hybrid rare earth up-conversion luminescence nanometer material has a controllable size, a uniform particle size and good biocompatibility; the material has a good mesoporous structure and good biocompatibility and can realize high-capacity loading of guest molecules; and the material can be used for detection of hydrosulfate radical ions in a solution and living cells.

Description

Technical field: [0001] The invention belongs to the technical field of luminescent nanometer materials. It specifically relates to the preparation of a kind of inorganic rare earth up-conversion luminescent nanoparticles coupled with organic fluorescent dyes and its application in biological detection and biological imaging. Background technique: [0002] Hydrogen sulfide is recognized as a toxic gas because of its irritating smell of rotten eggs. Studies have found that it is also one of the products of the metabolic process of organisms, and hydrogen sulfide is closely related to many pathological and physiological processes. Although high concentrations of hydrogen sulfide are very harmful to organisms, hydrogen sulfide is considered to be the third important gas transmitter for regulating the cardiovascular, nervous, and immune systems in addition to nitric oxide, carbon monoxide, and nitrogen. In addition, hydrogen sulfide also plays a vital role in maintaining the bo...

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Problems solved by technology

[0008] However, although the research on rare earth up-conversion luminescent nanomaterials has achi

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