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Water-soluble micro-powder containing amoxicillin and preparation method thereof

A technology of amoxicillin and micropowder is applied in the field of water-soluble micropowder and its preparation, which can solve the problems of poor dissolution rate of amoxicillin, increase the absorption of amoxicillin, etc. The effect of mass production

Active Publication Date: 2015-06-17
YANTAI JINHAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a water-soluble micropowder containing amoxicillin, to solve the problem of poor dissolution of amoxicillin, and then increase the absorption of amoxicillin in the gastrointestinal tract, and enhance the treatment of amoxicillin Effect

Method used

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  • Water-soluble micro-powder containing amoxicillin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] For example, to produce 100kg of water-soluble micropowder containing amoxicillin, 10kg of amoxicillin, 0.02kg of piperine, 2.5kg of PVP K30, 2.5kg of SDS, mix evenly, and inject the mixture and dry air into the ultrafine pulverizer together, Grinding to obtain a fine particle size of 500-1000 meshes, adding 84.98kg of mannitol and mixing uniformly.

[0031] Treat the broiler chicken that suffers from salmonellosis with the water-soluble micropowder that contains amoxicillin among the embodiment 1, experiment is as follows:

[0032] 1. Test animals

[0033] 90 broiler chickens suffering from salmonellosis were randomly selected and randomly divided into 3 groups, 30 in each group, with a body weight of 1.5kg-2kg.

[0034] 2. Experimental drugs

[0035] The water-soluble micropowder containing amoxicillin prepared in Example 1 of the present invention;

[0036] Ordinary amoxicillin powder: prepared by mixing 10% amoxicillin and 90% starch evenly by mass....

Embodiment 2

[0053] For example, to produce 100kg of water-soluble micropowder containing amoxicillin, 12kg of amoxicillin, 0.5kg of piperine, 2.6kg of PVP K30, 2.6kg of SDS, mix well, and inject the mixture and dry air into a superfine pulverizer for pulverization Obtain particle diameter and be the fine powder of 500-1000 order, add the mannitol of 82.3kg and mix uniformly to make.

Embodiment 3

[0055] Such as producing 100kg water-soluble compound amoxicillin powder, 10kg amoxicillin, 0.1kg piperine, 2.5kg PVP K30, 2.5kg SDS, 5kg quinolones (ofloxacin), mix well; mix the mixture with dry air Co-inject into a superfine pulverizer to pulverize to obtain a fine powder with a particle size of 500-1000 mesh, add 79.9 kg of mannitol and mix uniformly to prepare.

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Abstract

The invention relates to the field of veterinary medicinal products, and in particular relates to water-soluble micro-powder containing amoxicillin. The micro-powder comprises amoxicillin, piperine, PVPK30 (polyvinylpyrrolidone K30), SDS (sodium dodecyl sulfonate) and mannitol. The preparation method adopts a micro-micronization technology and comprises the following steps: mixing the amoxicillin, the piperine, the PVP K30 and the SDS; crushing the mixture with an ultrafine grinder to obtain fine powder with grain diameter of 500-1,000 meshes (16-25mu m), adding the mannitol, and uniformly mixing. The water-soluble compound amoxicillin micro-powder can be prepared from the micro-powder and other medicines. The amoxicillin prepared by adopting the method is finer and uniform in granularity, increased in surface area, enlarged in porosity and strengthened in adsorbability and solubility, can be well dispersed and dissolved in gastric juice to increase the contact area with gastric mucosa, so that the amoxicillin can be absorbed by gastrointestinal tracts more easily, and the solubility of amoxicillin can be increased; the preparation process is simpler than an enveloping process, easy to operate and more suitable for large-scale production.

Description

technical field [0001] The invention relates to the field of veterinary medicine products, in particular to a water-soluble micropowder containing amoxicillin and a preparation method thereof. Background technique [0002] Amoxicillin is a new generation of semi-synthetic acid-resistant broad-spectrum penicillin antibiotics. The basic structure that plays a major role in the antibacterial activity of amoxicillin is the β-lactam ring in 6-aminopenicillanic acid (unstable in case of alkali), which can specifically bind to the penicillin-binding protein on the bacterial inner membrane , and then inhibit the activity of bacterial cell wall mucopeptide synthase, so that short peptides cannot be transformed into chain structures, the only way for bacteria to build cell walls is cut off, and bacteria cannot continue to generate cell walls during proliferation, resulting in cell wall defects, cells cannot The spheroid is shaped into a spheroid, and the spheroid cannot withstand the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/43A61K47/22A61J3/02A61K31/4704A61K31/496A61K31/65A61K31/4375A61P31/04A61K31/137A61K31/635
Inventor 赵成新
Owner YANTAI JINHAI PHARMA