Baohuoside I tablet and preparation method thereof

A technology of baohuoside and tablet, applied in the field of medicine, can solve the problems of complex production process of dry powder inhalation dosage form, poor oral absorption of baohuoside I, unsuitable for large-scale production, etc., so as to increase bioavailability and reduce production. cost, effect of enhancing bioavailability

Inactive Publication Date: 2014-05-07
SICHUAN HETAI SYNLIGHT BIOTECH LTD
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the dry powder inhaler does not use propellants and solvents, it relies on the airflow to atomize the drug powder, and then the drug powder is delivered to the lungs. However, the dosage form of dry powder inhaler has complicated production process, high production cost, and poor patient compliance, so it is not suitable for large-scale production
[0005] Oral administration is the most common way of administration at present, and it is popular because of its simple production process, easy to carry and take by patients, while Baohuoside Ⅰ has poor oral absorption and low bioavailability, so the prepared product has a high dissolution rate Baohuoside Ⅰ tablet with good absorption and high bioavailability has become the focus of research in the field of medicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Baohuoside I tablet and preparation method thereof
  • Baohuoside I tablet and preparation method thereof
  • Baohuoside I tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: A baohuoside I tablet, which consists of the following raw materials in parts by weight: baohuoside I 6, diluent 55, binder 1.5, disintegrant 1.5, lubricant 0.5, surfactant 0.1;

[0038] The diluent is lactose monohydrate, direct compression lactose, microcrystalline cellulose PH101, microcrystalline cellulose PH102, and the weight ratio is 1:2:2:1; the binder is povidone K30, carboxymethyl Cellulose sodium, and weight ratio is 1:1; Described disintegrant is crospovidone, croscarmellose sodium, and weight ratio is 1:2; Described lubricant is stearic acid, Talc powder, sodium stearyl fumarate, and the weight ratio is 3:1:1; the surfactant is micronized poloxamer 188, micronized poloxamer 407, and the weight ratio is 2:3.

[0039] The preparation method of above-mentioned baohuoside I tablet, it comprises the following steps:

[0040] S1. Weighing: Weigh each raw material according to the above formula, and divide the weighed disintegrant into two parts of ...

Embodiment 2

[0048] Embodiment 2: A baohuoside I tablet, which is composed of the following raw materials in parts by weight: baohuoside I 30, diluent 86, binder 2.5, disintegrant 7, lubricant 5, surfactant 6;

[0049] The diluent is glucose, mannitol, sorbitol, sucrose, cornstarch, and the weight ratio is 1:1:5:3:3; the binder is povidone K90; the disintegrant is cross-linked Povidone, low-substituted hydroxypropyl cellulose, and the weight ratio is 5:3; the lubricant is micronized silica gel, talcum powder, and the weight ratio is 2:1; the surfactant is lauryl sulfate sodium.

[0050] The preparation method of above-mentioned baohuoside I tablet, it comprises the following steps:

[0051]S1. Weighing: Weigh each raw material according to the above formula, and divide the weighed disintegrant into two parts of equal weight, A and B, for later use;

[0052] S2. Mixing: mix the weighed baohuoside I, diluent, disintegrating agent A, and surfactant evenly;

[0053] S3. Pulverization: put p...

Embodiment 3

[0059] Embodiment 3: A baohuoside I tablet, which is composed of the following raw materials in parts by weight: 14 baohuoside I, 74 diluents, 1.7 binders, 4.3 disintegrants, 1.3 lubricants, and 2.9 surfactants;

[0060] The diluent is sorbitol, starch slurry, and the weight ratio is 3:2; the binder is povidone K30, povidone K90, and the weight ratio is 4:3; the disintegrating agent is cross-linked Sodium carboxymethyl cellulose, cross-linked sodium carboxymethyl starch, and the weight ratio is 1.5:1; the lubricant is stearic acid; the surfactant is polyoxyethylene 40 hydrogenated castor oil.

[0061] The preparation method of above-mentioned baohuoside I tablet, it comprises the following steps:

[0062] S1. Weighing: Weigh each raw material according to the above formula, and divide the weighed disintegrant into two parts of equal weight, A and B, for later use;

[0063] S2. Mixing: mix the weighed baohuoside I, diluent, disintegrating agent A, and surfactant evenly;

[00...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
wavelengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a baohuoside I tablet, which is prepared from the following raw materials in parts by weight: 6-30 parts of baohuoside I, 55-86 parts of diluents, 1.5-2.5 parts of adhesives, 1.5-7 parts of disintegrants, 0.5-5 parts of lubricants, and 0.1-6 parts of surfactants. The method for preparing the baohuoside I tablet comprises the following steps: weighing, mixing, crushing, pelletizing, drying, granulating, blending and tabletting. The baohuoside I tablet has the beneficial effects that the baohuoside I tablet disclosed by the invention has the advantages of being easy to disintegrate in water, high in dissolution rate, even to disperse and convenient to take, and the preparation method has the characteristics of being simple in process, convenient to operate, and low in production cost.

Description

technical field [0001] The invention relates to a baohuoside I tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Epimedium is a traditional tonic Chinese medicine, which has various functions such as tonifying kidney yang, strengthening muscles and bones, and dispelling rheumatism. Baohuoside Ⅰ (Baohuoside Ⅰ), also known as icariside Ⅱ (Ⅰcarisid Ⅱ), chemical name: 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone-3-0 -ɑ-L-rhamnopyranoside, whose chemical structure is shown in (I), is a polyhydroxy flavonoid monomer component, which exists in a small amount in Radix Acanthopanax and Epimedium pilosa. Baohuoside Ⅰ has stronger and wider pharmacological activities than icariin, and has outstanding effects on anti-osteoporosis, improving body immunity, anti-oxidation, and preventing and treating cardiovascular and cerebrovascular diseases; It also has good preventive and therapeutic effects. Baohuoside Ⅰ has obvious...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61K47/34A61K47/44A61K47/12A61P19/10A61P37/04A61P39/06A61P9/10A61P25/28
Inventor 杜彦军曾大富莫春雷黄依娟
Owner SICHUAN HETAI SYNLIGHT BIOTECH LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap