A kind of radial block copolymer and preparation method thereof

A technology of block copolymer and polylactic acid, which is applied in the field of star block copolymer and its preparation, can solve the problems of difficult preparation, low coupling efficiency, side reactions, etc., and achieve the effect of broad application prospects

Active Publication Date: 2016-04-06
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The number of arms of the star-shaped polymer obtained by this method is controllable, and the number of arms is determined by the number of initiator groups, but the disadvantages are: because the multifunctional initiator must be synthesized in advance, the preparation is difficult; there are side reactions during polymerization; When the size of the nucleus changes and the number of arms disperses, it will cause several nuclei to link together to form a large nucleus
However, the coupling efficiency is too low, and the product contains a certain amount of linear macromolecules, and the structure is incomplete, etc.

Method used

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  • A kind of radial block copolymer and preparation method thereof
  • A kind of radial block copolymer and preparation method thereof
  • A kind of radial block copolymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 8.0 g of polystyrene containing an azide end group with a molecular weight of 10000, 86.5 mg of compound A, 0.45 g of sodium ascorbate, and 1.05 g of copper sulfate, dissolve them in a mixed solvent composed of tetrahydrofuran / water, and react at room temperature for 24 hours. Evaporate the organic solvent under reduced pressure, precipitate with methanol, filter and dry in vacuo to obtain a two-arm polystyrene with a hydroxyl group in the center; dissolve the two-arm polystyrene with a hydroxyl group in the center in dichloromethane , add 0.5g 4-dimethylaminopyridine and 0.3g 4-pentynoic acid, and react at room temperature for 10 hours. Dichloromethane was distilled off under reduced pressure, precipitated with methanol, filtered and vacuum-dried to obtain a two-arm polystyrene with an alkynyl group in the central point; taking the two-arm polystyrene with an alkynyl group in the central point, the molecular weight was 15000 polylactic acid containing an azide te...

Embodiment 2

[0023] Weigh 6.0 g of polystyrene with a molecular weight of 20,000 containing an azide end group, 32.4 mg of compound A, 0.23 g of sodium ascorbate, and 0.53 g of copper sulfate, dissolve them in a mixed solvent of tetrahydrofuran / water, and react at room temperature for 36 hours. Evaporate the organic solvent under reduced pressure, precipitate with methanol, filter and dry in vacuo to obtain a two-arm polystyrene with a hydroxyl group in the center; dissolve the two-arm polystyrene with a hydroxyl group in the center in dichloromethane , add 0.32g 4-dimethylaminopyridine and 0.21g 4-pentynoic acid, and react at room temperature for 24 hours. Dichloromethane was distilled off under reduced pressure, precipitated with methanol, filtered and vacuum-dried to obtain a two-arm polystyrene with an alkynyl group in the central point; taking the two-arm polystyrene with an alkynyl group in the central point, the molecular weight was 23000 polylactic acid containing an azide terminal...

Embodiment 3

[0025] Weigh 10.0g of polystyrene with a molecular weight of 15,000 containing an azide terminal group, 72.0mg of compound A, 0.43g of sodium ascorbate, and 0.98g of copper sulfate, dissolve them in a mixed solvent composed of tetrahydrofuran / water, and react at 40°C for 20 hours, evaporate the organic solvent under reduced pressure, precipitate with methanol, filter and dry in vacuo to obtain a two-arm polystyrene with a hydroxyl group in the center; dissolve the two-arm polystyrene with a hydroxyl group in the center in dichloro Add 0.75g of 4-dimethylaminopyridine and 0.68g of 4-pentynoic acid to methane, and react at room temperature for 36 hours. Dichloromethane was distilled off under reduced pressure, precipitated with methanol, filtered and vacuum-dried to obtain a two-arm polystyrene with an alkynyl group in the central point; taking the two-arm polystyrene with an alkynyl group in the central point, the molecular weight was 12000 polyethylene oxide containing an azid...

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Abstract

The invention belongs to the technical field of polymer materials, and in particular relates to a star-shaped block copolymer and a preparation method thereof. The specific method is: through Huisgen cycloaddition reaction, polystyrene and polylactic acid or polyoxyethylene are successively connected to the same core molecule to form an A2B three-arm star-shaped block copolymer. The three-arm star-shaped copolymer prepared by the present invention has a precise and controllable molecular chain structure, can be used for self-assembly in solution to form core-shell nanomicelles, and can also be used for microphase separation under heating to form regular and ordered Nano-phase separation structure, and further prepared into a nano-organic porous material with regular pore structure and high specific surface area, has broad application prospects in the fields of drug sustained release and nano-separation.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a star-shaped block copolymer and a preparation method thereof. Background technique [0002] The so-called star-shaped polymer refers to a star-shaped polymer that contains more than three chains and each chain has no distinction between main and branched chains. They are all connected to the same point by chemical bonds. It has a three-dimensional snowflake-like structure and is a special type of branched polymer. At present, the preparation methods of star-shaped copolymers include two techniques: nuclear first and then arm method and first arm and then nuclear method. The former refers to the use of multifunctional initiators to initiate monomer polymerization or the generation of free radicals on the main chain to initiate monomer polymerization to form star-shaped copolymers, while the latter is to synthesize monofunctional active linear macromolecula...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02C08J3/24
Inventor 宋杰李建波任杰
Owner TONGJI UNIV
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