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Derivatives containing thiadiazole or oxadiazole and application of derivatives in prevention and control of agricultural plant diseases

A technology of thiadiazole derivatives and derivatives, applied in the direction of chemicals, applications, and biocides for biological control, can solve the problems of unreported agricultural activity, achieve simple structure, broad application prospects, and production low cost effect

Inactive Publication Date: 2014-05-14
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2-mercapto-5-substituent-1,3,4-thia(oxa)diazole derivatives have received more attention in medical applications due to their excellent physiological activities, but their agricultural activities have not been reported yet

Method used

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  • Derivatives containing thiadiazole or oxadiazole and application of derivatives in prevention and control of agricultural plant diseases
  • Derivatives containing thiadiazole or oxadiazole and application of derivatives in prevention and control of agricultural plant diseases
  • Derivatives containing thiadiazole or oxadiazole and application of derivatives in prevention and control of agricultural plant diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Determination of Indoor Inhibition of Bacterial Disease Pathogen Activity of Some Compounds

[0045] (1) Determination of the indoor activity of some compounds against rice bacterial blight

[0046] The rice bacterial blight pathogen was incubated in M210 (enzymatically hydrolyzed casein: 8 g, sucrose: 5 g, yeast extract: 4 g, K 2 HPO 4 : 3 g, MgSO 4 ·7H 2O: 0.3 g, agar: 15 g, secondary water: 1 L, pH = 7.0) Streak on the solid medium, culture at 28 °C until a single colony grows. Pick a single colony of rice bacterial blight pathogen on M210 solid medium to M210 liquid medium (enzymatically hydrolyzed casein: 8 g, sucrose: 5 g, yeast extract: 4 g, K 2 HPO 4 : 3 g, MgSO 4 ·7H 2 O: 0.3 g, secondary water: 1 L, pH=7.0), cultured on a constant temperature shaker at 28 °C and 180 rpm until the logarithmic phase of growth was set aside.

[0047] The synthesized compound and the control drug were respectively configured at a concentration of 200 and 100 mu...

Embodiment 2

[0061] Embodiment 2: Determination of the activity of some compounds inhibiting fungal pathogens of crops indoors

[0062] The antibacterial activity of the compounds was determined by the in vitro growth rate method. Heat the potato dextrose agar medium (PDA medium: 200 g potato, 20 g agar, 20 g glucose, 1000 mL distilled water) to the molten state (40-60 ℃), and dissolve 10 mL of the drug solution (10 times the final concentration of the drug solution ) into 90 mL PDA medium, shake well, pour evenly into a 9 cm diameter petri dish, place it horizontally, and wait for cooling to solidify. At the edge of the fresh pathogenic bacteria colony that has been cultured for 4 days, a 4 mm diameter bacterial disk was punched out with a puncher, and the bacterial disk was placed upside down in the center of the PDA plate containing the drug, and then placed in a constant temperature and humidity incubator at 27 °C for upside-down cultivation. When the colonies of the blank control gre...

Embodiment 3

[0067] Embodiment three: highly active compound toxicity regression equation and inhibitory medium concentration (EC 50 ) value determination

[0068] (1) Regression equation and EC of compound toxicity to rice bacterial blight pathogen 50 Determination of value

[0069] The synthetic compound and the control agent were respectively prepared into 5 corresponding concentrations of toxic M210 liquid medium, 5 mL was taken in a test tube, and the OD value of the toxic sterile liquid medium was measured with a microplate reader (OD 595 ), adding 40 mu L containing the M210 liquid medium containing the pathogenic bacteria of Xanthomonas oryzae, then cultured on a constant temperature shaker at 28 °C and 180 rpm for 24-48 h, and measured the OD value of each concentration of the bacterial solution with a microplate reader (OD 595 ). In addition, the OD value of the toxic and sterile M210 liquid medium containing the control drug and the OD value of the bacterial solution of each...

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Abstract

The invention discloses 2-sulfydryl-5-substituent group-1,3,4-thiadiazole (oxadiazole) derivatives with the function of preventing and controlling bacterial and fungal diseases of crops. Due to excellent physiological activity, the derivatives get more attention in the medical field, but the agricultural activity of the derivatives is still not reported at present. The research shows that the derivatives can be used for effectively inhibiting pathogens of such bacterial diseases as rice bacterial blight, rice bacterial leaf streak, tobacco bacterial wilt and tomato bacterial wilt and pathogens of such fungal diseases as wheat scab, potato late blight, apple canker, capsicum wilt, cucumber gay mold and sclerotia sclerotium. Meanwhile, when applied to prevention and control of the bacterial and fungal diseases of crops, the 2-sulfydryl-5-substituent group-1, 3, 4-thiadiazole (oxadiazole) derivatives has the advantages of simple structure, simple the preparation process, low the production cost and wide application prospect. The 2-sulfydryl-5-substituent group-1, 3, 4-thiadiazole (oxadiazole) derivatives has a general formula shown in the specification.

Description

technical field [0001] The invention relates to chemical industry and pesticide, and the specific technology is the application of a class of 1,3,4-thia(oxa)diazole derivatives to prevent and control bacterial and fungal diseases of crops. Background technique [0002] As a large agricultural country, my country plays an extremely important role in ensuring agricultural production. Aiming at the current problems of major agricultural bacterial and fungal diseases, scientifically and efficiently discovering green pesticide candidates that are safe and have potential market vitality is an important task in the basic research of new pesticide creation in my country. Lead discovery is the key to realizing innovative green chemical pesticides. It is extremely urgent and important to design, optimize and synthesize several types of pesticide lead structures, and to develop new low-toxicity, low-residue, safe green chemical pesticides. [0003] Plant diseases caused by pathogenic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D285/125C07D271/113C07D413/04C07D417/04A01N43/824A01P1/00A01P3/00
CPCA01N43/82C07D271/113C07D285/125C07D413/04C07D417/04
Inventor 宋宝安李培杨松胡德禹薛伟金林红徐维明贺鸣施利杨霞史庆才吴芳
Owner GUIZHOU UNIV
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