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Method for preparing europium-doped hydroxyapatite nanorod

A hydroxyapatite and nanorod technology, applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve harsh conditions, complex preparation process of europium-doped hydroxyapatite, material crystallinity, fluorescence intensity and dispersion. It is difficult to achieve good uniformity and other problems, so as to achieve the effects of low equipment requirements, good dispersion and luminescence performance, and controllable morphology.

Inactive Publication Date: 2014-05-14
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing preparation process of europium-doped hydroxyapatite is complicated and the conditions are harsh, and the crystallinity, fluorescence intensity and dispersion of the prepared material are difficult to achieve a good unity

Method used

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  • Method for preparing europium-doped hydroxyapatite nanorod
  • Method for preparing europium-doped hydroxyapatite nanorod
  • Method for preparing europium-doped hydroxyapatite nanorod

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Weigh 1.7597g of europium oxide, then add 30ml of dilute nitric acid with a concentration of 4mol / L, stir for 30 minutes under heating conditions, and after completely dissolving, prepare a 0.2mol / L europium nitrate solution.

[0019] Weigh 1.584g of diammonium hydrogen phosphate and 1g of cetyltrimethylammonium bromide into the beaker, measure 50ml of distilled water into the beaker and dissolve, adjust the pH value to 12 with 1mol / L NaOH solution , is solution 1. Weigh 2.109g of anhydrous calcium chloride and add it to another beaker, add 25ml of distilled water to dissolve it, and use a pipette to measure 5ml of the prepared europium nitrate solution and add it to the beaker, which is solution 2. Then the solution 2 was slowly added dropwise to the continuously stirring solution 1, the mixed solution was heated to 100° C., and reacted for 6 hours. After the reaction was completed, the suspension was left to stand for 3 hours, and then the precipitate was washed 8 ti...

Embodiment 2

[0024] Weigh 1.7597g of europium oxide, then add 30ml of dilute nitric acid with a concentration of 4mol / L, stir for 30 minutes under heating conditions, and after completely dissolving, prepare a 0.2mol / L europium nitrate solution.

[0025] Weigh 1.584g of diammonium hydrogen phosphate and 1g of cetyltrimethylammonium bromide into the beaker, measure 50ml of distilled water into the beaker and dissolve, adjust the pH value to 12 with 1mol / L NaOH solution , is solution 1. Weigh 2.198g of anhydrous calcium chloride and add it to another beaker, add 25ml of distilled water to dissolve it, take 1ml of the prepared europium nitrate solution with a pipette and add it to the beaker, which is solution 2. Then the solution 2 was slowly added dropwise to the continuously stirring solution 1, the mixed solution was heated to 100° C., and reacted for 6 hours. After the reaction was completed, the suspension was left to stand for 3 hours, and then the precipitate was washed 5 times with ...

Embodiment 3

[0027] Weigh 1.7597g of europium oxide, then add 30ml of dilute nitric acid with a concentration of 4mol / L, stir for 30 minutes under heating conditions, and after completely dissolving, prepare a 0.2mol / L europium nitrate solution.

[0028] Weigh 1.584g of diammonium hydrogen phosphate and 1g of cetyltrimethylammonium bromide into the beaker, measure 50ml of distilled water into the beaker and dissolve, adjust the pH value to 12 with 1mol / L NaOH solution , is solution 1. Weigh 1.998g of anhydrous calcium chloride and add it to another beaker, add 25ml of distilled water to dissolve it, and use a pipette to measure 10ml of the prepared europium nitrate solution and add it to the beaker to form solution 2. Then the solution 2 was slowly added dropwise to the continuously stirring solution 1, the mixed solution was heated to 100° C., and reacted for 6 hours. After the reaction was completed, the suspension was left to stand for 3 hours, and then the precipitate was washed 10 ti...

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Abstract

The invention discloses a method for preparing a europium-doped hydroxyapatite nanorod. According to the method, diammonium hydrogen phosphate, cetyl trimethyl ammonium bromide, anhydrous calcium chloride and europium oxide are used as raw materials, a mixed solution of the anhydrous calcium chloride and europium nitrate is dropwise added to a mixed solution of the diammonium hydrogen phosphate and the cetyl trimethyl ammonium bromide, the mixed solutions react at a certain temperature, after the reaction is over, precipitate is washed in distilled water and distilled water for multiple times and dried in the suction filtration process, and then the europium-doped hydroxyapatite nanorod is obtained. According to the method, the reaction temperature is low, the requirement for equipment is low, operation is simple, and the prepared material is controllable in shape, high in purity, good in crystallinity, dispersity and luminescence property, and wide in application prospect.

Description

technical field [0001] The invention relates to a method for preparing europium-doped hydroxyapatite nanorods, which belongs to the field of preparation of biological materials and luminescent materials. Background technique [0002] Hydroxyapatite (HA) has good biological activity and certain mechanical properties, and has become one of the biomaterials that material researchers pay close attention to. HA is the main component of vertebrate bones and teeth, accounting for 97% in dentary bones and 75% in human bones. Nanoscale HA has broad application prospects in bone repair, such as alveolar ridge augmentation, ear ossicle replacement, oral implants, and vertebral bone replacement. In addition, due to the excellent biocompatibility, chemical stability and surface properties of nanoscale HA, it has been widely used in the fields of antitumor and drug delivery. [0003] As a bone repair material, HA is easy to loosen under the action of body fluid at the initial stage of i...

Claims

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Application Information

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IPC IPC(8): C09K11/71B82Y30/00
Inventor 孙康宁徐欣
Owner SHANDONG UNIV
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