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Medical sacculus and preparation method thereof

A balloon and medical technology, which is applied in the field of medical devices, can solve the problems of high cost, drug shedding, and high requirements for the proficiency and professional level of processing personnel, so as to improve the specific surface area and roughness, and the preparation method is simple and reliable. Effects of Adhesion and Drug Loading Rate

Active Publication Date: 2014-05-21
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the need to process fine and small non-planar structures on the outer surface of the balloon body, these mechanical processing methods usually require expensive precision processing equipment such as ultraviolet laser equipment, etc., and the proficiency and professional level of processing personnel are also relatively high. Require
There are also technicians who improve the loading rate of drugs by forming macro-concave-convex patterns such as wrinkles, ridges and ravines on the surface of the balloon body (see publication number CN201524344U and titled "New Balloon Catheter Carrying Drug Microcapsules" Chinese Utility Model Application, and Chinese Invention Application Publication No. CN101987222A titled "A Surface Strip Balloon Catheter"), but such macroscopic concave-convex patterns, even if loaded with sufficient drug when applied, are still prone to loss during delivery. Drug shedding occurs during washout and

Method used

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  • Medical sacculus and preparation method thereof
  • Medical sacculus and preparation method thereof
  • Medical sacculus and preparation method thereof

Examples

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Effect test

example 1

[0031] Pebax 6333 material and PEO material were melt-blended at 230°C through a twin-screw extruder at a volume ratio of 30:70 to prepare Pebax / PEO blended material. The pure Pebax7233 material and the Pebax / PEO blended material were prepared through a co-extrusion process to prepare a double-layer tube, and the outer diameter of the prepared tube was 0.040 inches, and the inner diameter was 0.022 inches. The inner layer of the pipe is Pebax7233 material, and the outer layer is Pebax / PEO blend material, wherein the outer layer has a cross-sectional area of ​​15%. The above pipe was stretched at a stretching ratio of 4.0 at 60°C. Insert the stretched tubing into the balloon mold of the balloon molding machine, form a balloon body with an outer diameter of 3.0mm at 90°C and a molding pressure of 490psi, and immediately heat-fix at 105°C for 30s and then water-cool. The prepared balloon body is ultrasonically oscillated in deionized water for 2 hours to dissolve the water-solub...

example 2

[0033] Nylon 12 / PVA blended material was prepared by melt blending nylon 12 material and PVA material at a volume ratio of 70:30 through a twin-screw extruder at 250 °C. The nylon 12 material and the nylon 12 / PVA blended material were prepared through a co-extrusion process to prepare a double-layer pipe, and the outer diameter of the prepared pipe was 0.028 inches, and the inner diameter was 0.015 inches. The inner layer of the pipe is nylon 12 material, and the outer layer is nylon 12 / PVA blend material, wherein the outer layer has a cross-sectional area of ​​30%. The above pipe was stretched at a stretching ratio of 3.5 at 60°C. Insert the stretched tubing into the balloon mold of the balloon forming machine, form a balloon body with an outer diameter of 2.0 mm at 90°C and a molding pressure of 500 psi, and immediately heat-fix at 110°C for 1 min and then water-cool. The prepared balloon body is ultrasonically oscillated in deionized water for 2 hours to dissolve the water...

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Abstract

The invention relates to the field of medical appliances, and provides a medical sacculus and a preparation method thereof. The medical sacculus comprises a main body and a drug coating which is arranged on the main body and is used for treating hemadostenosis. The medical sacculus is characterized in that the main body comprises an inner layer which is made of a non-water-soluble polymer material, and an outer layer which is made of a non-water-soluble polymer material and is provided with a porous structure, wherein the pore size of the main body is submicron or micron, and the drug coating is coated on the outer surface of the outer layer and a hole in the porous structure of the outer layer. The invention further provides a method of preparing the medical sacculus. According to the medical sacculus, drugs are guaranteed to be firmly stuck and loaded on the outer layer of the main body, the initial drug capacity is increased, and the drug loss in a sacculus delivery process is reduced, so that after the medical sacculus reaches a diseased region, the sufficient drug quantity is released to a vascular wall, and furthermore, the preparation method of the medical sacculus is simple, reliable and lower in cost, and is beneficial for mass production.

Description

technical field [0001] The present invention relates to the technical field of medical devices. More specifically, the present invention provides a medical balloon and a preparation method thereof. Background technique [0002] Endovascular angioplasty has been widely used in the treatment of cardiovascular and peripheral vascular stenosis diseases. It sends a balloon catheter into the stenosis of the blood vessel through percutaneous puncture intervention, and uses the expansion of the balloon to restore the stenosis. The diameter of the lumen of the blood vessel is the purpose of increasing the blood flow, but the restenosis rate of the blood vessel after 3-6 months of balloon dilatation is still as high as 30%-50%. In order to make up for the shortcomings of simple balloon dilation surgery, various vascular stents have come out one after another, especially the use of drug-coated vascular stents has significantly reduced the rate of vascular restenosis. However, with th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/10B29D23/00
Inventor 姜闻博李立夫陈树国石秀凤唐智荣罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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