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Application of eleutheroside e in preparation of medicine for treating rheumatoid arthritis

A rheumatoid and eleutheroside technology, which is applied in the field of medicine, can solve the problems of low activity and no research reports, and achieve the effects of reducing antibody levels, reversing joint pathological damage, and clear prospects for industrialization

Active Publication Date: 2016-01-20
THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As a known monomer compound, eleutheroside E is not very active in research despite its exact molecular formula and structural formula. At present, there are very few reports on the pharmacological effects of eleutheroside E. It is mainly used to lower blood sugar, resist central fatigue, improve myocardial mechanical changes caused by pituitary hormone, and reduce the incidence of myocardial infarction. It is mainly used in the prevention and treatment of cardiovascular and cerebrovascular diseases in clinical practice.
So far, there has been no research report on the application of eleutheroside E as a monomer in the preparation of drugs for the treatment of rheumatoid arthritis.

Method used

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  • Application of eleutheroside e in preparation of medicine for treating rheumatoid arthritis
  • Application of eleutheroside e in preparation of medicine for treating rheumatoid arthritis
  • Application of eleutheroside e in preparation of medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] Preparation of serum: After taking blood from mice in each group through orbital extraction, centrifuge at 4000r / min for 20min at 4°C overnight, and carefully take the supernatant and place it in a 0.5ml centrifuge tube. The prepared serum was stored in a refrigerator at -20°C to determine the level of anti-collagen type II antibodies in the serum.

[0045] 3. Joint score

[0046] Mouse joint inflammation and scoring were as follows: 0: no significant change; 1: obvious swelling and redness of one toe; 2: mild swelling and erythema of limbs or swelling of two toes; 3: three toes appeared Obvious swelling and erythema of the limbs; 4: Swelling and redness of the entire joint, and even joint stiffness.

[0047] 4. Histopathological observation:

[0048] The hind paws (hind paws and joints) of mice were fixed with 10% formaldehyde, then soaked in 10% EDTA solution for two days for decalcification, embedded in paraffin, tissue sections of 5 μm, and then stained with HE. ...

Embodiment 1

[0058] Example 1 Effect of eleutheroside E on mouse joints, body weight and foot volume

[0059] Experimental mice were treated with eleutheroside E by intragastric administration, and the joint score, body weight and hind paw thickness were counted. The results showed that the hind paws of the mice in the model group had obvious redness and swelling and joint stiffness, while eleutheroside E and TG The lesion degree of the mice in the treatment group was significantly reduced ( Figure 1A ). Compared with the model group, the joint scores and weight loss of mice in the 15mg / kg TG treatment group, 30mg / kg and 60mg / kg eleutheroside E treatment groups were significantly reduced (P0.05), see Figure 1B with 1C . The thickness of the hind paw of mice in the 30mg / kg and 60mg / kg eleutheroside E treatment groups decreased significantly from 42 days to 56 days after the first injection, but the 15mg / kg eleutheroside E treatment group did not show significant improvement effect, see...

Embodiment 2

[0060] Example 2 The effect of eleutheroside E treatment on joint bone destruction

[0061] Mammography X-ray plain films and micro-CT examinations were carried out on the hind paws of the mice. The molybdenum-palladium X-ray films showed that the hind paw joints of the mice in the model group were obviously destroyed, displaced and irregular bone hyperplasia, while eleutheroside E ( 30mg / kg, 60mg / kg) and TG (15mg / kg) treatment groups, the degree of bone destruction in mice was significantly reduced, see Figure 2A . Correspondingly, the scores of the degree of bone destruction of the mice in the eleutheroside E (30mg / kg, 60mg / kg) and TG (15mg / kg) treatment groups were also significantly reduced (P Figure 2C . Compared with the model group, the mice in the 15mg / kg eleutheroside E treatment group did not show significant improvement (P>0.05). Using micro-CT to scan the hind paws of the mice, it was also found that the mice in the model group had obvious joint destruction, and...

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Abstract

The invention relates to a novel application of eleutheroside E, in particular to an application of the eleutheroside E in preparation of a rheumatoid arthritis treatment medicine and medicine composition for treating the rheumatoid arthritis. The medicine composition for treating the rheumatoid arthritis can be prepared into tablets, capsules, a dissolved medicine, drops, granules, an ointment or an injection through the eleutheroside E with purity higher than 98% (mass percentage) added with universal auxiliary medical components. Pharmacology experiment results show that the eleutheroside E can remarkably improve the joint swelling condition of the rheumatoid arthritis, reduce the arthritis index, reverse pathologic change of arthritis, has no critical defects of clinically common medicines, and has the function of the rheumatoid arthritis resistance with high efficiency and low toxicity. Therefore, the eleutheroside E can be used for preparing the medicine for treating the rheumatoid arthritis. The invention provides a novel medicine source for treating the rheumatoid arthritis.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of eleutheroside E in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid arthritis, RA) is a multi-system inflammatory autoimmune disease mainly involving peripheral joints, with unknown etiology. Rheumatoid arthritis is the most common inflammatory joint disease clinically, which seriously affects the functional status, quality of life and life expectancy of patients. Because of its chronic characteristics, related complications and long-term dysfunction, it has a huge impact on society and economy . The current treatment of rheumatoid arthritis is mainly based on drug therapy (commonly used drugs are non-steroidal anti-inflammatory drugs, newly listed biological agents such as TNF-a inhibitors), but none of the drugs can really completely control the development of the disease, and Ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P19/02A61P29/00
Inventor 何春燕闫兆威朱雪明陈晓辉
Owner THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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