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Preparation method of loaded-calcium phosphorus silver nanotube array on medical titanium surface

A silver nanotube, calcium phosphorus technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, to achieve the effect of great clinical use prospects, improved antibacterial properties, and improved proliferation

Inactive Publication Date: 2014-06-04
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on modifying the surface of medical titanium so that the implant has both biological activity and antibacterial properties has not been reported.

Method used

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  • Preparation method of loaded-calcium phosphorus silver nanotube array on medical titanium surface
  • Preparation method of loaded-calcium phosphorus silver nanotube array on medical titanium surface
  • Preparation method of loaded-calcium phosphorus silver nanotube array on medical titanium surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 0.05 mol of NaF powder, dissolve it in 500 ml of simulated body fluid (SBF), and stir evenly with magnetic force to obtain a NaF electrolyte with a concentration of 0.1M. Then weigh 0.01mol of AgNO 3 Dissolve the powder in 100ml deionized water and stir it evenly to obtain AgNO with a concentration of 0.1M 3 electrolyte. Medical pure titanium sheet (model: TA1, size 10mm×10mm×1mm, the same as the following examples) is polished with sandpaper, then cleaned with acetone, ethanol and deionized water, and then placed in 0.1M NaF electrolyte as an anode In this case, plate-shaped graphite (the size of graphite is 40mm×40mm×5mm, the same as in the following examples) is used as the cathode, and the distance between the cathode and the anode is 40mm. Anodizing treatment is carried out by WYK-150 DC power supply device, and its process parameters are room temperature, 10V, 1h. After the treatment, the titanium sheet was taken out from the electrolyte, rinsed with deio...

Embodiment 2

[0031] Weigh 0.02 mol of NaF powder, dissolve it in 100 ml of simulated body fluid (SBF), and stir evenly with magnetic force to obtain a NaF electrolyte with a concentration of 0.2M. Then weigh 0.001mol of AgNO 3 Dissolve the powder in 100ml deionized water, and stir evenly with a magnetic force to obtain AgNO with a concentration of 0.01M 3 electrolyte. The medical pure titanium sheet is anodized by WYK-150 DC power supply unit. The electrode type, position, anodic oxidation temperature and experimental procedures are all the same as those described in Example 1, except that the oxidation voltage used in the NaF electrolyte is 10V, and the oxidation time is 2h. 3 The oxidation voltage in the electrolyte is 5V, and the oxidation time is 3min. After the finally obtained titanium sheet samples were rinsed with deionized water, they were left to dry in the air.

[0032] Carry out the performance detection in embodiment 1, find that the nanotube array of uniform distribution ...

Embodiment 3

[0034] Weigh 0.1 mol of NaF powder, dissolve it in 100 ml of simulated body fluid (SBF), stir evenly with magnetic force to obtain NaF electrolyte with a concentration of 1M. Then weigh 0.05mol of AgNO 3 Dissolve the powder in 100ml deionized water and stir it evenly to obtain AgNO with a concentration of 0.5M 3 electrolyte. The medical pure titanium sheet is anodized by WYK-150 DC power supply unit. Electrode type, position, anodic oxidation temperature and experimental procedure are all described in Example 1, the difference is that the distance between cathode and anode is 50mm, the oxidation voltage used in NaF electrolyte is 30V, and the oxidation time is 30min. AgNO 3 The oxidation voltage selected in the electrolyte is 10V, and the oxidation time is 1min. After the finally obtained titanium sheet samples were rinsed with deionized water, they were left to dry in the air.

[0035] Carry out the performance test in embodiment 1, find that the nanotube array is formed...

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Abstract

The invention discloses a preparation method of a loaded-calcium phosphorus silver nanotube array on a medical titanium surface. The method comprises the steps as follows: the nanotube array of which the diameter is smaller than 100nm is generated on the titanium surface after anode oxidation treatment for twice; three elements calcium, phosphorus and silver are loaded, and the nanotube array has good biological activity, biocompatibility and antibacterial property. By adopting the preparation method, the titanium implant material with good overall performance is obtained, a plurality of defects existing in the titanium implant can be improved, and the nanotube array has great clinical prospect. Not only can great economic benefits be generated by application of the nanotube array, but also physical and mental pain of the majority of patients after operations can be relieved, and the preparation method plays a positive effect on acceleration of social harmony.

Description

technical field [0001] The technical solution of the present invention relates to the preparation of an antibacterial bioactive bone replacement material, specifically the preparation method of medical titanium with nanotube arrays on the surface and loaded with three elements of calcium, phosphorus and silver, belonging to the field of biological materials . Background technique [0002] With the acceleration of the aging process of society and the increase of fractures and bone defects caused by accidents such as car accidents, people's demand for bone implant materials is increasing year by year. According to incomplete statistics, in 2006, nearly 2 million sets of artificial joints were sold worldwide, and the market turnover exceeded 2 billion US dollars. Since the middle and late 1990s, the domestic market of artificial joints in China has been developing rapidly with an annual growth rate of more than 15%, from less than 10,000 sets in 1998 to about 90,000 sets in 20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/12B82Y40/00B82Y30/00
Inventor 李宝娥李军李海鹏梁春永王洪水
Owner HEBEI UNIV OF TECH
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