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Esomeprazole pharmaceutical composition and preparation thereof

The technology of a kind of esomeprazole, composition, is applied in the field of esomeprazole pharmaceutical composition and preparation thereof, can solve the problems such as influence esomeprazole stripping, weak acid resistance, achieves good antacid effect, Reduced dosage and strong acid resistance

Inactive Publication Date: 2014-06-11
LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chinese patent CN 102078616A discloses a composition of esomeprazole sodium bicarbonate, wherein 20-40 mg of esomeprazole magnesium salt, 1100-1680 mg of sodium bicarbonate and other auxiliary materials are combined in a fixed unit dosage form. The composition has a faster onset of action, but weaker acid resistance, which affects the dissolution of esomeprazole in acid

Method used

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  • Esomeprazole pharmaceutical composition and preparation thereof
  • Esomeprazole pharmaceutical composition and preparation thereof
  • Esomeprazole pharmaceutical composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Esomeprazole Lithium Capsules

[0038]

[0039] The raw and auxiliary materials were crushed separately and sieved; the main drug esomeprazole was mixed evenly with a part of potassium bicarbonate by the method of equal increase, and granulated, and then mixed evenly with the remaining potassium bicarbonate, magnesium oxide, and magnesium stearate, and added 10% starch slurry, granulated, granulated, dried and filled into empty capsule shells.

Embodiment 2

[0041] Esomeprazole Lithium Capsules

[0042]

[0043] Preparation method is the same as embodiment 1

Embodiment 3

[0045] Esomeprazole Magnesium Capsules

[0046]

[0047] Preparation method is the same as embodiment 1

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Abstract

The invention provides an esomeprazole pharmaceutical composition with stronger acid resistance and a preparation thereof. The esomeprazole pharmaceutical composition comprises esomeprazole, one or more antacids and common pharmaceutical adjuvants, wherein the esomeprazole comprises esomeprazole salt, particularly esomeprazole magnesium salt and esomeprazole lithium salt; and the antacids comprise sodium bicarbonate, sodium carbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, aluminum carbonate, magnesium carbonate, magnesium hydroxide, magnesium oxide, aluminium hydroxide, magnesium aluminum carbonate and the like. The preparation of the esomeprazole pharmaceutical composition is prepared by adding the antacids via interior addition and exterior addition; and in an optimized preparation method, the weight ratio of the antacids in the interior addition and the exterior addition is 2: 3, so that the antacids play double efficacies, the dosage of acid neutralization agent is reduced and the acid resisting effect is better.

Description

technical field [0001] The invention relates to an esomeprazole pharmaceutical composition and a preparation thereof, belonging to the technical field of medicines. Background technique [0002] Proton pump inhibitors (PPIs) are a class of drugs that have been widely used clinically in recent years and have the strongest antiacid effect. It has been considered as the most effective drug for the treatment of stomach-related diseases, and has developed rapidly in recent years. Proton pump inhibitors are weakly basic benzimidazole compounds, which enter the secretory tubules of the parietal cells after absorption, and in the acidic environment of the lumen, interact with H + The combination further forms an active product, which irreversibly binds to the proton pump inhibitor to inactivate the proton pump, thereby inhibiting the acid secretion function of the proton pump. PPIs act on the last step of gastric acid secretion by parietal cells, and are currently the most effecti...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K33/00A61K33/06A61K33/08A61K33/10A61K31/4439A61P1/04
Inventor 关屹闫冬
Owner LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH
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