Spectinomycin tablet and preparation method thereof

Abstract

The present invention relates to a spectinomycin tablet and a preparation method thereof, wherein the spectinomycin tablet adopts the following components by weight: 10-50% of spectinomycin and 50-90% of a pharmaceutical auxiliary material, wherein the pharmaceutical auxiliary material comprises one or a plurality of materials selected from a disintegrating agent, a filler, a wetting binder and a lubricant. The invention further discloses the preparation method of the spectinomycin. The preparation method comprises: respectively crushing and screening spectinomycin and a pharmaceutical auxiliary material, mixing the obtained spectinomycin and the filler, adding one part of the disintegrating agent, adding the wetting binder to prepare a soft material, preparing wet granules, drying, finishing, adding the remaining disintegrating agent, adding the lubricant, uniformly mixing, and tabletting to prepare the spectinomycin tablet.

Description

technical field [0001] The invention relates to a spectinomycin tablet and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Spectinomycin is an antibiotic drug, tetracycline drug, which can treat chlamydia mycoplasma infection. Its properties are light yellow or yellow crystalline powder, smelly and bitter. Soluble in water or methanol, slightly soluble in ethanol or acetone, insoluble in chloroform. It is mainly used for the treatment of respiratory, urinary tract and biliary tract infections caused by sensitive bacteria. The antibacterial spectrum is basically the same as that of tetracycline and oxytetracycline, and its antibacterial activity in vivo and in vitro is stronger than that of tetracycline. Microorganisms have close cross-resistance to this product and tetracycline, oxytetracycline, etc. Oral absorption is good. It is mainly used for upper respiratory tract infection, flat strip inflammation,...

AI Technical Summary

Problems solved by technology

[0003] Spectinomycin is a poorly soluble drug, and the dissolution rate of products produced by different processes in the human body is significantly different. The bioavailability of spectinomycin preparations produced by different processes is significantly different, which affects the curative effect of the drug itself.

[0004] Ordinary tablet preparation methods use starch, dextrin, hydroxypropyl cellulose, etc. as auxiliary materials. The production process is: crushing, mixing, granulating, and tabletting. Spectinomycin tablets prepared by this method are difficult to be absorbed and utilized.