Composition for use in increasing insulin sensitivity and/or reducing insulin resistance

一种组合物、混合物的技术，应用在食用油/脂肪、应用、食物科学等方向，能够解决没有效果、功效有限、有害的效果等问题

Active Publication Date: 2014-06-25
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of these nutritional interventions is very limited and even controversial, with studies showing no or even harmful effects

Method used

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  • Composition for use in increasing insulin sensitivity and/or reducing insulin resistance
  • Composition for use in increasing insulin sensitivity and/or reducing insulin resistance
  • Composition for use in increasing insulin sensitivity and/or reducing insulin resistance

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0097] The preparation of the compositions of the invention will be described by way of examples.

[0098] Formulations can be prepared in any suitable manner. For example, it can be prepared by mixing together a protein source, a carbohydrate source (other than an oligosaccharide mixture) and a fat source including LC-PUFA in suitable ratios. Emulsifiers, if used, may be included at this point. Vitamins and minerals can be added at this point, but are usually added later to avoid thermal decomposition. Any lipophilic vitamins, emulsifiers, etc. may be dissolved in the fat source prior to blending. Water, preferably reverse osmosis water, may then be mixed in to form a liquid mixture. The temperature of the water typically ranges from about 50°C to about 80°C to aid in the dispersion of the ingredients. Commercially available liquefiers can be used to form the liquid mixture. If the final product is in liquid form, the oligosaccharide mixture is added at this stage. If t...

Embodiment

[0115] Trials were carried out regarding the supplementation effect of an oligosaccharide mixture enriched in galactose-oligosaccharides (demineralised, lactose-free whey permeate or DDWP) and 2'-fucoid A mixture of milk oligosaccharides (CMOS) of glycosyllactose (FL) and lactose-N-neotetraose (LNnT), which were added separately to the mixture DDWP (in two comparable implementations example) or in combination (according to the invention) LC-PUFA (arachidonic acid-ARA- and docosahexaenoic acid-DHA-) and Bifidobacterium lactis (BL) were added to the mixture DDWP.

[0116] 1. Methodology

[0117] Experimental protocol

[0118] Experiments were performed under the Swiss Animal Protection Act and approved by the Office Vétérinaire Cantonal (Lausanne, Switzerland, authorization N° 2028). Breeding males and virgin female Long-Evans Hooded rats were purchased from Janvier (France) and arrived at the animal care facility two weeks prior to mating.

[0119] Pregnant females receivi...

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PUM

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Abstract

The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid, at least one probiotic and a mixture of oligosaccharides, said mixture containing at least one of lacto-N-neotetraose (LNnT) and lacto-N-tetraose (LNT), at least one N-acetylated oligosaccharide different from LNnT and LNT, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in increasing insulin sensitivity and / or reducing insulin resistance. This composition optionally further comprises 2′-fucosyllactose (FL). This composition is particularly adapted for use in infants who were born preterm and / or who experienced IUGR, in pregnant women suffering from gestational diabetes and in children, adolescents, and adults suffering from insulin resistance and / or type II diabetes.

Description

field of invention [0001] The present invention relates to compositions for increasing insulin sensitivity and / or reducing insulin resistance. The composition is for mammals, preferably humans, more preferably infants. Background of the invention [0002] Carbohydrates ingested from glucidic foods (bread, pasta, potatoes, fruit, sugar...) are converted into glucose during intestinal digestion. Glucose passes through the intestinal wall and enters the bloodstream. This causes blood sugar spikes; increasing blood glucose levels, which are about 1 gram per liter of blood during the fasting period. Insulin is the hormone responsible for lowering blood glucose levels during post-digestion metabolism. Elevated blood glucose after a meal period triggers pancreatic insulin secretion, which causes glucose storage by body organs, especially the liver and muscles. This reverses blood sugar to fasting levels. [0003] In healthy individuals, insulin secretion is proportional to blo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23D9/00A23L1/052A23L1/30A61K31/00A23L29/206A23L33/00
CPCA23V2200/00A61K31/202A61K31/702A23L1/3014A61K31/7004A23L1/308A23L1/296A23L1/3006A61K31/7016A61K35/745A23V2002/00A23L33/40A23L33/115A23L33/135A23L33/21A61K2300/00A23V2200/328A23L29/30
Inventor C·加西亚-罗德纳斯
Owner SOC DES PROD NESTLE SA
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