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A nano-spherical hollow hydroxyapatite powder and its preparation method

A hollow hydroxyapatite and spherical technology, which is applied in the field of biomedical material engineering, can solve the problems of rough surface and limited application range, and achieve the effect of smooth surface, uniform size and perfect crystallinity

Active Publication Date: 2016-08-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydroxyapatite hollow microspheres obtained by the above two preparation methods are all in the micron scale range, and the surface is not smooth, and its application range is limited

Method used

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  • A nano-spherical hollow hydroxyapatite powder and its preparation method
  • A nano-spherical hollow hydroxyapatite powder and its preparation method
  • A nano-spherical hollow hydroxyapatite powder and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 0.0607g of calcium stearate, 2mL of oleic acid and 20mL of toluene into the reaction vessel, put it into the stirring rotor, raise the temperature to 100°C under magnetic stirring, and keep stirring at this temperature until the solution is optically transparent (time about 2min) , Stop heating then, make it cool to room temperature, form the calcium stearate solution that calcium ion concentration is 0.005mol / L. 0.0228g sodium phosphate dodecahydrate (Na 3 PO 4 ) was dissolved in 20mL deionized water to make sodium phosphate (Na3 PO 4 ) aqueous solution. The prepared sodium phosphate (Na 3 PO 4 ) aqueous solution into the prepared calcium stearate solution (the Ca / P molar ratio of the reaction system is 1.67), after the sodium phosphate aqueous solution is added dropwise, continue to stir at a stirring rate of 800r / min for 2min and then stop stirring, and then at 60°C React in a water bath for 10 hours; after the reaction time expires, age at room temperature ...

Embodiment 2

[0038] Add 0.0607g of calcium stearate, 2mL of oleic acid and 20mL of toluene into the reaction vessel, put in the stirring rotor, heat to 70°C under magnetic stirring, and keep stirring at this temperature until the solution is optically transparent (time about 2min) , Stop heating then, make it cool to room temperature, form the calcium stearate solution that calcium ion concentration is 0.005mol / L. 0.0228g sodium phosphate dodecahydrate (Na 3 PO 4 ) was dissolved in 20mL deionized water to make sodium phosphate (Na 3 PO 4 ) aqueous solution. The prepared sodium phosphate (Na 3 PO 4 ) aqueous solution into the prepared calcium stearate solution (the Ca / P molar ratio of the reaction system is 1.67), after the sodium phosphate aqueous solution is added dropwise, continue to stir at a stirring rate of 700r / min for 2min and then stop stirring, then at 40°C React in a water bath for 10 hours; after the reaction time expires, age at room temperature for 20 hours and break th...

Embodiment 3

[0041] Add 0.0607g of calcium stearate, 2mL of oleic acid and 20mL of toluene into the reaction vessel, put it into the stirring rotor, raise the temperature to 80°C under magnetic stirring, and keep stirring at this temperature until the solution is optically transparent (time about 2min) , Stop heating then, make it cool to room temperature, form the calcium stearate solution that calcium ion concentration is 0.005mol / L. 0.0228g sodium phosphate dodecahydrate (Na 3 PO 4 ) was dissolved in 20mL deionized water to make sodium phosphate (Na 3 PO 4 ) aqueous solution. The prepared sodium phosphate (Na 3 PO 4 ) aqueous solution into the prepared calcium stearate solution (the Ca / P molar ratio of the reaction system is 1.67), after the sodium phosphate aqueous solution is added dropwise, continue to stir at a stirring rate of 600r / min for 2min and then stop stirring, and then at 80°C React in a water bath for 10 hours; after the reaction time expires, age at room temperature...

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Abstract

The invention discloses nanometer spherical hollow hydroxyapatite powder. The particle size of the nanometer spherical hollow hydroxyapatite powder is not more than 50nm, and the shell thickness of the nanometer spherical hollow hydroxyapatite powder is 5nm-8nm. The invention further discloses a preparation method of the nanometer spherical hollow hydroxyapatite powder. The preparation method comprises the following steps: respectively dissolving a calcium source and a phosphorus source in oil and water which cannot dissolve each other so as to obtain a calcium source solution and a phosphorus source solution, mixing the calcium source solution and the phosphorus source solution and reacting so as to obtain the nanometer spherical hollow hydroxyapatite powder. The particle size of the nanometer spherical hollow hydroxyapatite powder prepared by the method is below 50nm, and the shell thickness of the nanometer spherical hollow hydroxyapatite powder is 5-8nm; the nanometer spherical hollow hydroxyapatite powder has regular morphology and smooth and flat surface and is perfect in degree of crystallinity and uniform in size; and the preparation method has the advantages of simple preparation technology, shortened production cycle, good repeatability, low cost and the like and is beneficial to industrial production.

Description

technical field [0001] The invention belongs to the technical field of biomedical material engineering, and relates to a nano-spherical hollow hydroxyapatite powder and a preparation method thereof. Background technique [0002] Hydroxyapatite (HA) has good biocompatibility and bioactivity, and has broad application prospects in the fields of tissue repair, drugs, and gene carriers. Nano-hydroxyapatite has the characteristics of high surface energy and large specific surface area, and shows special biological properties due to its nanoscale characteristics. Some studies have shown that nano-hydroxyapatite can pass through the tumor cell membrane to cause tumor cell apoptosis and It has shown application prospects in anti-tumor, and at the same time, it is also an ideal drug carrier material, which can improve the permeability of drugs in biomembranes, facilitate the absorption of drugs, and control the slow release of drugs. In recent years, the application of nano-hydroxya...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
Inventor 赵欢朱禹达范红松蔡兵
Owner SICHUAN UNIV
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