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Zinc gluconate oral spray and preparation method thereof

The technology of zinc gluconate and oral spray, which is applied in the field of medicine, can solve the problems that diabetic patients cannot take it normally, are not suitable for patients to use, and the sugar tablet contains high amount of white sugar, so as to avoid metallic taste, be happy to take, and taste good Effect

Active Publication Date: 2016-02-10
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Chinese patent document CN1100306A discloses a kind of compound zinc gluconate capsule, tablet, buccal tablet and preparation method thereof, main medicine is zinc gluconate, ibuprofen, chlorpheniramine, processed into capsule, tablet, buccal tablet , the taste of the lozenge is bitter, because zinc gluconate rapidly releases zinc ions in the mouth, it has a special taste, and the taste is poor when it is contained, so it is not suitable for use by patients
[0009] 2. Due to the high sugar content of the sugar tablet (about 32.28% of the weight of the sugar tablet), patients with diabetes cannot take it normally;

Method used

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  • Zinc gluconate oral spray and preparation method thereof
  • Zinc gluconate oral spray and preparation method thereof
  • Zinc gluconate oral spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Embodiment 1, the preparation of zinc gluconate oral spray

[0090] A: 28 parts of zinc gluconate;

[0091] B: Pharmaceutical excipients: 10 parts of glycerin, 1 part of sucralose, 9 parts of glycine, 10 parts of fruit flavoring agent, 1000 parts of purified water;

[0092] C: Antibacterial agent: 0.05 part of sodium benzoate, 0.05 part of benzalkonium chloride;

[0093] Prepared as follows:

[0094] (1) In the 100,000-class clean area, weigh zinc gluconate, glycine, glycerin, sodium benzoate, benzalkonium chloride, sucralose, purified water and flavoring fruit flavoring agents according to the prescription amount for later use.

[0095] (2) In the 100,000-class clean area, add zinc gluconate, glycine, glycerin, sucralose and purified water into the dissolving tank, start stirring, heat up to 80°C to dissolve completely, and set aside at room temperature;

[0096] (3) The solution obtained in step (2) is sterilized by filtration with a 0.22 μm filter membrane, then t...

Embodiment 2

[0100] Embodiment 2, the preparation of zinc gluconate oral spray

[0101] A: 120 parts of zinc gluconate;

[0102] B: Pharmaceutical excipients: 44 parts of glycerin, 4 parts of sucralose, 39 parts of glycine, 44 parts of fruit flavoring agent, 4390 parts of purified water;

[0103] C: Antibacterial agent: 0.21 parts of sodium benzoate, 0.21 parts of benzalkonium chloride;

[0104] Prepared as follows:

[0105] (1) In the 100,000-class clean area, weigh zinc gluconate, glycine, glycerin, sucralose, purified water, and flavoring fruit flavoring agents according to the prescription for later use.

[0106] (2) In the 100,000-class clean area, add zinc gluconate, glycine, glycerin, sodium benzoate, benzalkonium chloride, sucralose and purified water into the dissolution tank, start stirring, and heat up to 60°C to make it Dissolve completely and store at room temperature for later use;

[0107] (3) The solution obtained in step (2) is sterilized by filtration with a 0.22 μm f...

Embodiment 3

[0111] Embodiment 3, the preparation of zinc gluconate oral spray

[0112] Zinc gluconate oral spray, the composition of raw and auxiliary materials is as follows:

[0113] A: 74 parts of zinc gluconate;

[0114] B: pharmaceutical excipients: 27 parts of glycerin, 2.5 parts of sucralose, 24 parts of glycine, 27 parts of fruit flavoring agent, 2695 parts of purified water;

[0115] C: Antibacterial agent: 0.13 parts of sodium benzoate, 0.13 parts of benzalkonium chloride;

[0116] Prepared as follows:

[0117] (1) In the 100,000-class clean area, weigh zinc gluconate, glycine, glycerin, sodium benzoate, benzalkonium chloride, sucralose, purified water and flavoring fruit flavoring agents according to the prescription amount for later use.

[0118] (2) In the 100,000-class clean area, add zinc gluconate, glycine, glycerin, sucralose and purified water into the dissolution tank, start stirring, heat up to 70-80°C to dissolve completely, and set aside at room temperature;

[011...

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Abstract

Te invention relates to a zinc gluconate oral spray and a preparation method thereof. The oral spray comprises the following components in parts by mass: A, 28 to 164 parts of zinc gluconate, B, pharmaceutic adjuvants, and C, bacteriostatic agent, wherein the pharmaceutic adjuvants comprise 10 to 16 parts of glycerinum, 1 to 6 parts of sucralose, 9 to 53 parts of glycine, 10 to 60 parts of fruity agent, and 1,000 to 6,000 parts of purifiedwater; and the bacteriostatic agent comprises 0.05 to 0.29 part of sodium benzoate, and 0.05 to 0.29 part of benzalkonium chloride. The preparation method comprises the following steps: heating to dissolve the components; agitating; filtering and sterilizing; and sub-packing to obtain the product in a form of the spray. The zinc gluconate oral spray is used by spraying orally, thus zinc ions can permeate the sensitive structures of nose, pharynx and paranasal sinus to be combined with a cold receptor, and then the zinc ions in mucosas of nose, pharynx and paranasal sinus form a screen for preventing common cold virus from further dispersing among cells, and as a result, the purposes of treating cold and reducing symptoms of cold are reached.

Description

technical field [0001] The invention relates to a zinc gluconate oral spray for treating colds and alleviating cold symptoms and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] The common cold is one of the most common diseases in the world. The causes of colds are mostly caused by colds and viral infections. There are more than 200 viruses that can cause colds, including rhinoviruses (the most common cause), coronaviruses, adenoviruses, and respiratory syndromes. cell thin virus, and parainfluenza virus. Cold is a disease that cannot be ignored, and it is one of the major public health problems faced by human beings. According to statistics, the annual incidence of common cold is 10-30%, and tens of thousands of people are infected every year all over the world. Almost everyone has personal experience. Almost no one has never had a cold in his life. The symptoms are: nasal congestion, runny nose, sneezing, coughin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K31/315A61K47/18A61P11/00A61P3/02
Inventor 乔敏袁武杰刘钢李红新孟震晓邵兰兰
Owner SHANDONG SBOND PHARMA
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