A method for preparing low-acid ginkgo extract by negative pressure boiling extraction

A technology of ginkgo extract and negative pressure extraction, which is applied in the directions of medical raw materials, drug combinations, cardiovascular system diseases, etc. derived from Ginkgo biloba The problem of low ester content, etc., achieves the effect of simple process operation, shortened extraction time and improved extraction rate
CN103961381BActive Publication Date: 2017-05-24邳州恒翔生物制品有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
邳州恒翔生物制品有限公司
Publication Date
2017-05-24

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Abstract

The invention relates to a method for negative-pressure boiling extraction and preparation of a low-acid ginkgo extract from ginkgo leaves. According to the method, crushed fresh ginkgo leaves or dry ginkgo leaves are used as a raw material, hydrous ethanol is used as an extraction solvent, negative-pressure boiling extraction is carried out, then a liquid extract is filtered and then pretreated by using quartz sand and microporous centrifugal filtration, a filtrate is separated and purified by using a ceramic membrane and an ultrafiltration membrane, a solution passing through the ultrafiltration membrane is concentrated by using a nanofiltration membrane, then ethanol is recovered, a concentrate is subjected to purification with a macroporous resin and phenolic acid removal with a deacidification resin, and negative-pressure microwave spray drying or vacuum freeze drying is carried out so as to obtain the low-acid ginkgo extract. The low-acid ginkgo extract prepared by using the method has a low acid value, high purity, ginkgetin content of more than 28%, lactone content of more than 8% and ginkgolic acid of no greater than 1 ppm, and the method may become a novel technology for industrial production of a low-acid ginkgo extract product.
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Description

Technical field

[0001] The invention relates to the technical field of plant extracts, in particular to a method for preparing a low-acid ginkgo extract from ginkgo leaves by negative pressure boiling extraction. Background technique

[0002] Ginkgo Biloba (Ginkgo Biloba L.) is a living fossil and a symbol of longevity. Ginkgo biloba is rich in anti-disease biologically active factors, such as flavonoids, lactones, polypentenol, polysaccharides, proteins, etc., and has attracted international attention. The German Schwabe company uses solvent extraction technology to produce standard ginkgo biloba extract (GBE761). The main active substances are flavonoids and lactones, which are best-selling botanicals for the treatment of cardiovascular and cerebrovascular diseases. Internationally, the annual sales of Ginkgo biloba extract (GBE) and preparations reached 6.5 billion U.S. dollars, consistently ranking the top three in the US herbal medicine market. Ginkgo is an important econo...

Claims

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