Polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as preparation method and application thereof

A technology of ferrous sulfide and polyethylene glycol, applied in the field of medicine, can solve the problems of toxic and side effects of patients, cancer cell removal, difficulty and the like, and achieve the effects of remarkable effect, good water solubility and simple preparation method.

Active Publication Date: 2014-09-03
南京金凯木纳米材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Today, cancer treatment mainly includes surgery, chemotherapy and radiotherapy, but each treatment has its limitations: surgery is often difficult to completely remove all cancer cells in the body, especially when cancer cells have metastasized ;Chemotherapy and radiotherapy are poisonous to cancer cells and normal cells with no difference or little difference, have great toxic side effects, and may induce drug resistance of cancer cells
However, these clinically approved contrast agents are only used as magnetic resonance contrast agents for disease diagnosis, and have no disease treatment effect
In this way, disease diagnosis and treatment are two relatively independent processes, and both diagnosis and treatment medicines will cause certain toxic and side effects to patients.

Method used

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  • Polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as preparation method and application thereof
  • Polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as preparation method and application thereof
  • Polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as preparation method and application thereof

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Experimental program
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preparation example Construction

[0075] Such as figure 1 As shown, the preparation method of the polyethylene glycol-modified ferrous sulfide magnetic nanometer diagnostic agent comprises the steps:

[0076] S1. Taking the ferrous sulfide nanosheets as the base layer, coating the trioctyl phosphorus oxide layer on the surface of the base layer to obtain the ferrous sulfide nanosheets with the trioctyl phosphorus oxide layer formed on the surface;

[0077] S2. modifying the octylamine-polyacrylic acid layer on the trioctylphosphine oxide layer to obtain a negatively charged functional material A;

[0078] S3. Connect polyallylamine hydrochloride on the octylamine-polyacrylic acid layer to form a polyallylamine hydrochloride layer to obtain a positively charged functional material B;

[0079] S4. Connecting polyacrylic acid to the formed polyallylamine hydrochloride layer to form a polyacrylic acid layer to obtain a negatively charged functional material C;

[0080] S5. Modifying hexaamino branched-chain poly...

Embodiment

[0091] In a 50ml three-necked flask, add 0.39mmol of ferrous acetylacetonate and 0.78mmol of trioctylphosphine oxide, and then add 10ml of oleylamine. Under the protection of nitrogen, first heat to 140°C for 30 minutes, then slowly raise the temperature to 220°C for 1 hour.

[0092] Then, 5 ml of oleylamine dissolved with 3.125 mmol of sulfur powder was quickly injected into the reaction liquid, and then reacted at 220° C. for 1 h. After the reaction, wash four times with a mixed solution of cyclohexane and ethanol, and finally disperse in 5ml cyclohexane to obtain a cyclohexane solution of ferrous sulfide nanosheets.

[0093] The synthetic ferrous sulfide is characterized below.

[0094] Such as figure 2 Shown, it is the transmission electron microscope picture of the ferrous sulfide synthesized, can find out from this picture that ferrous sulfide surface is coated with a large amount of trioctyl phosphorus oxide layer, and the formation is coated with trioctyl phosphorus...

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Abstract

The invention discloses a polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as a preparation method and application thereof, wherein the polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent has a laminar structure, and sequentially comprises a ferrous sulfide layer, a trioctylphosphine oxide layer, an octylamine-polyacrylic acid layer, a poly allyamine hydrochloride layer and a polyacrylic acid layer from inside to outside; hexa-amino branched polyethylene glycol is modified on the polyacrylic acid layer. The treatment agent disclosed by the invention can have high enrichment amount at the tumor part by retention and osmosis action of the tumor, and then photothermal therapy is carried out, so that the effect is significant, the other parts are not damaged, and the tumor does not reappear after being cured. Compared with the prior art, the polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent is significant in effect. In addition, the cancer can be subjected to early diagnosis by magnetic resonance imaging, meanwhile, real-time monitoring can be carried out in recovered magnetic resonance arthrography, a reasonable treatment plant can be provided by combining with a real-time monitoring result, and the polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent can be widely applied to a clinical diagnosis and treatment technology.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a polyethylene glycol-modified ferrous sulfide magnetic nano-diagnosis and treatment agent and a preparation method thereof, as well as its application in the preparation of medical imaging reagents and photothermal therapy drugs for tumors guided by imaging. Background technique [0002] Cancer has become the biggest killer affecting human health and life in the 21st century. According to the latest survey report in the United States, about 1,529,960 new cancer cases were diagnosed in 2011, and about 569,490 Americans died of cancer, with an average of more than 1,500 deaths per day. Malignant tumors have become the number one "killer" that threatens human health and life. [0003] Today, cancer treatment mainly includes surgery, chemotherapy and radiotherapy, but each treatment has its limitations: surgery is often difficult to completely remove all cancer cells in the body, especially...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K41/00A61P35/00
Inventor 杨凯刘庄
Owner 南京金凯木纳米材料有限公司
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