Polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as preparation method and application thereof

Abstract

The invention discloses a polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent as well as a preparation method and application thereof, wherein the polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent has a laminar structure, and sequentially comprises a ferrous sulfide layer, a trioctylphosphine oxide layer, an octylamine-polyacrylic acid layer, a poly allyamine hydrochloride layer and a polyacrylic acid layer from inside to outside; hexa-amino branched polyethylene glycol is modified on the polyacrylic acid layer. The treatment agent disclosed by the invention can have high enrichment amount at the tumor part by retention and osmosis action of the tumor, and then photothermal therapy is carried out, so that the effect is significant, the other parts are not damaged, and the tumor does not reappear after being cured. Compared with the prior art, the polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent is significant in effect. In addition, the cancer can be subjected to early diagnosis by magnetic resonance imaging, meanwhile, real-time monitoring can be carried out in recovered magnetic resonance arthrography, a reasonable treatment plant can be provided by combining with a real-time monitoring result, and the polyethylene glycol-modified ferrous sulfide magnetic nanometer treatment agent can be widely applied to a clinical diagnosis and treatment technology.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a polyethylene glycol-modified ferrous sulfide magnetic nano-diagnosis and treatment agent and a preparation method thereof, as well as its application in the preparation of medical imaging reagents and photothermal therapy drugs for tumors guided by imaging. Background technique [0002] Cancer has become the biggest killer affecting human health and life in the 21st century. According to the latest survey report in the United States, about 1,529,960 new cancer cases were diagnosed in 2011, and about 569,490 Americans died of cancer, with an average of more than 1,500 deaths per day. Malignant tumors have become the number one "killer" that threatens human health and life. [0003] Today, cancer treatment mainly includes surgery, chemotherapy and radiotherapy, but each treatment has its limitations: surgery is often difficult to completely remove all cancer cells in the body, especially...

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Problems solved by technology

[0003] Today, cancer treatment mainly includes surgery, chemotherapy and radiotherapy, but each treatment has its limitations: surgery is often difficult to completely remove all cancer cells in the body, especially when cancer cells have metastasized ;Chemotherapy and radiotherapy are poisonous to cancer cells and normal cells with no difference or little difference, have great toxic side effects, and may induce drug resistance of cancer cells

However, these clinically approved contrast agents are only used as magnetic resonance contrast agents for disease diagnosis, and have no disease treatment effect

In this way, disease diagnosis and treatment are two relatively independent processes, and both diagnosis and treatment medicines will cause certain toxic and side effects to patients.

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