Method for preparing calcium carbonate/octacalcium phosphate particles containing ibuprofen

A technology of octacalcium phosphate and calcium carbonate, which is applied to medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, which can solve problems such as unreported research, achieve simple preparation, and enhance drug utilization The effect of high efficiency, good dispersion and stability

Inactive Publication Date: 2014-10-01
SHANDONG UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Method for preparing calcium carbonate/octacalcium phosphate particles containing ibuprofen
  • Method for preparing calcium carbonate/octacalcium phosphate particles containing ibuprofen
  • Method for preparing calcium carbonate/octacalcium phosphate particles containing ibuprofen

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Embodiment 1

[0021] (1) Prepare an ethanol solution containing 0.0177 moles per liter of calcium chloride dihydrate and 4 grams per liter of ibuprofen in beaker A, seal it with plastic wrap and make 20 small holes, weigh 26 grams of ammonium bicarbonate powder and put Put it into beaker B, seal it with plastic wrap and make 20 small holes, put the beakers A and B into a desiccator equipped with silica gel, let it stand for 3 days, then centrifuge the solution in beaker A, wash it and dry it at 60oC Obtain the calcium carbonate particle containing ibuprofen after 12 hours;

[0022] (2) In a solution containing 34.58 milliliters of water and 9.10 milliliters of ethanol, add citric acid, calcium nitrate, diammonium hydrogen phosphate and ibuprofen in sequence to make the concentrations respectively 0.116 millimole per liter, 0.0569 millimole per liter, 0.0345 Millimoles per liter and 8.67 grams per liter, adjust the pH value of the solution to 9 with ammonia water, then add polyethylene glyco...

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Abstract

The invention provides a method for preparing calcium carbonate/octacalcium phosphate particles containing ibuprofen and belongs to the technical fields of new materials and pharmaceutical preparations. The method comprises the following steps: preparing an alcohol solution of calcium chloride dihydrate, then placing the alcohol solution into a drier holding both ammonium bicarbonate and silica gel, reacting for three days, then centrifuging, washing and drying to manufacture calcium carbonate particles containing ibuprofen, adding citric acid, calcium nitrate, diammonium phosphate and ibuprofen into a solution containing both water and ethyl alcohol, adjusting the pH value of the solution to 9, after that, adding polyethyleneglycol, adding the calcium carbonate particles containing ibuprofen after resolution of polyethyleneglycol, reacting for 3 hours, and finally centrifuging, washing and drying to obtain the calcium carbonate/octacalcium phosphate particles containing ibuprofen. The method is simple in process and low in cost and can be used for mass production. Ibuprofen is released from the particles to reflect the continuous slow release behavior, and the particles are excellent in biocompatibility and easy to degrade.

Description

technical field [0001] The invention provides a method for preparing ibuprofen-containing calcium carbonate / octacalcium phosphate particles, which belongs to the technical field of new materials and pharmaceutical preparations. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory drug and analgesic commonly used in clinical practice. The effect is more significant, and the toxic and side effects are less. When used to treat pain, an increase in the plasma concentration of ibuprofen can enhance the analgesic effect, which requires a rapid increase in the concentration of ibuprofen in the solution. Clinically, ibuprofen is usually administered orally. It tastes bitter, has low solubility, and is slowly absorbed. Moreover, the short half-life of the drug requires frequent administration of the drug. There are side effects such as nausea and abdominal distension when taking it orally for a long time, which is harmful to the human body. The damage is gre...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/04A61K31/192A61P29/00
Inventor 陆昊李成峰杨丽爽方艳峰王静囡葛筱璐
Owner SHANDONG UNIV OF TECH
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