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Application of euponin in the preparation of drugs for treating ischemic cardiovascular and cerebrovascular diseases

A technique for cardiovascular and cerebrovascular diseases and zelansu, which is applied in the field of biomedicine, can solve the problem that the research and application of ischemic cardiovascular and cerebrovascular diseases is not involved, and achieves improvement of poor memory acquisition, good therapeutic effect and simple preparation method. Effect

Inactive Publication Date: 2016-04-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are many reports on the plant source, isolation method and anti-tumor and bactericidal effects of eupholm, but no one has been involved in its research and application on ischemic cardiovascular and cerebrovascular diseases

Method used

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  • Application of euponin in the preparation of drugs for treating ischemic cardiovascular and cerebrovascular diseases
  • Application of euponin in the preparation of drugs for treating ischemic cardiovascular and cerebrovascular diseases
  • Application of euponin in the preparation of drugs for treating ischemic cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Zeolin Tablets (1000 Tablets)

[0027] Recipe: Euparin (Euparin), (provided by the Pharmaceutical Chemistry Laboratory of Xinxiang Medical College School of Pharmacy, purity > 96%, the following examples are the same) 200 parts, MCC (microcrystalline cellulose) 150 parts, magnesium stearate 10 parts share.

[0028] Preparation method: Mix euplenin and MCC evenly, moisten with water, pass through a 18-mesh sieve, dry, pass through a 22-mesh sieve again, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 2

[0030] Preparation of Zeolin Tablets (1000 Tablets)

[0031] Recipe: 300 parts of Zeilansu, 150 parts of lactose, 100 parts of sodium carboxymethylcellulose, and 20 parts of magnesium stearate.

[0032] Preparation method: Mix euplenin, lactose and sodium carboxymethylcellulose evenly, moisten with water, pass through a 18-mesh sieve, dry, pass through a 24-mesh sieve again, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 3

[0034] Preparation of Zeolin Tablets (1000 Tablets)

[0035] Recipe: 300 parts of Zeilansu, 200 parts of lactose, 10 parts of sodium carboxymethyl starch, and 15 parts of micronized silica gel.

[0036] Preparation method: Mix euplenin, lactose and sodium carboxymethyl starch evenly, moisten with water, pass through a 18-mesh sieve, dry, pass through a 24-mesh sieve again, then add micropowder silica gel, mix evenly, and press into tablets.

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Abstract

The invention provides an application of Euparin in preparing a medicine for treating ischemic cardiovascular and cerebrovascular diseases. According to the pharmacological experiments, the mouth open breathing time of a mouse after decapitation can be prolonged obviously by Euparin, the moisture content of brain tissue after cerebral ischemia can be reduced remarkably; MDA (methylene dioxyamphetamine) content of brain tissue of a forebrain ischemia mouse can be reduced and the SOD (superoxide dismutase) content can be elevated; the unfavorable mouse memory acquisition due to scopolamine can be alleviated; the raw materials for preparing Euparin are easy to get, the Euparin can be prepared into various normal dosage forms such as tablets, capsules and injections through normal methods and the preparing method is simple.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of euplenin in the preparation of drugs for treating ischemic cardiovascular and cerebrovascular diseases. Background technique [0002] Ischemic cardiovascular and cerebrovascular diseases are due to abnormal lipid metabolism in the body and blood imbalance, slowing down of blood flow, deposition of blood lipids on the vessel wall and retention of metabolites in the body, causing blood circulation in the coronary arteries of the heart and the brain. due to obstacles. At present, ischemic cardiovascular and cerebrovascular diseases have a relatively high clinical incidence rate, which seriously endangers the physical and mental health of middle-aged and elderly people. [0003] Among the ischemic cardiovascular and cerebrovascular diseases, cerebral infarction and myocardial infarction are more serious, and the fatality rate and complications are h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P9/00A61P9/10A61P25/28A61P7/02
Inventor 赵正杭詹合琴孙强沈志强
Owner XI AN JIAOTONG UNIV
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