Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof

A technology of composite nanofibers and bioglass, applied in the field of tissue repair materials and their preparation, can solve problems such as methods that have not yet been reported, achieve easy degradation, enhance biocompatibility and mechanical properties, biocompatibility and high effect

Inactive Publication Date: 2014-10-15
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no methods for preparing fish gelatin / mesoporous bioglass composite nanomaterials have been reported

Method used

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  • Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof
  • Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof
  • Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof

Examples

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Effect test

example 1

[0052] Dissolve ethylene oxide-propylene oxide-ethylene oxide triblock copolymer and hydrogen chloride in ethanol, stir at room temperature for 24 hours, then add ethyl orthosilicate, calcium nitrate, triethyl phosphate, continue stirring for 24 hours, and then After aging for 72 hours, a mesoporous bioglass gel with a concentration of 3.4g / 100ml was obtained.

[0053] Dissolve 0.16 gram of fish gelatin in 2 milliliters of hexafluoroisopropanol with an electronic analytical balance to obtain a fish gelatin solution with a concentration of 8 grams / 100 milliliters; after magnetic stirring at normal temperature is completely dissolved, take 0.235 milliliters of mesoporous bioglass gel and mix and Stir to obtain a fish gelatin / mesoporous bioglass blend solution with a mass ratio of 20 / 1, and after standing for ten minutes, electrospin the blend solution with a voltage of 18kv, a syringe pump with a propulsion speed of 1ml / h, and a receiving distance of 13cm. No. 9 needle, received...

example 2

[0056] Dissolve ethylene oxide-propylene oxide-ethylene oxide triblock copolymer and hydrogen chloride in ethanol, stir at room temperature for 24 hours, then add ethyl orthosilicate, calcium nitrate, triethyl phosphate, continue stirring for 24 hours, and then After aging for 72 hours, a mesoporous bioglass gel with a concentration of 3.4g / 100ml was obtained.

[0057] Dissolve 0.16 gram of fish gelatin in 2 milliliters of hexafluoroisopropanol with an electronic analytical balance to obtain a fish gelatin solution with a concentration of 8 grams / 100 milliliters; after magnetic stirring at normal temperature is completely dissolved, take 0.314 milliliters of mesoporous bioglass gel and mix and Stir to obtain a fish gelatin / mesoporous bioglass blend solution with a mass ratio of 15 / 1, and after standing for ten minutes, electrospin the blend solution with a voltage of 18kv, a syringe pump advancing speed of 1ml / h, and a receiving distance of 13cm. A No. 9 needle was selected an...

example 3

[0060] Dissolve ethylene oxide-propylene oxide-ethylene oxide triblock copolymer and hydrogen chloride in ethanol, stir at room temperature for 24 hours, then add ethyl orthosilicate, calcium nitrate, triethyl phosphate, continue stirring for 24 hours, and then After aging for 72 hours, a mesoporous bioglass gel with a concentration of 3.4g / 100ml was obtained.

[0061] Dissolve 0.16 g of fish gelatin on an electronic analytical balance in 2 ml of hexafluoroisopropanol to obtain a fish gelatin solution with a concentration of 8 g / 100 ml; stir magnetically at room temperature and after it is completely dissolved, take 0.471 ml of mesoporous bioglass gel and mix And stirring to obtain a fish gelatin / mesoporous bioglass blend solution with a mass ratio of 10 / 1, after standing for ten minutes, electrospin the blend solution, the voltage is 18kv, the advancing speed of the syringe pump is 1ml / h, and the receiving distance is 13cm , using a No. 9 needle, receiving aluminum foil or co...

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Abstract

The present invention provides a gelatin / mesoporous bioactive glass composite nanofiber membrane material and a preparation method thereof, and gelatin solution and mesoporous bioactive glass gel are mixed for preparation of a gelatin / mesoporous bioactive glass composite nanofiber membrane by an electrostatic spinning method. The gelatin / mesoporous bioactive glass composite nanofiber membrane is high in porosity and specific surface area and good in mechanical properties, and can be used for the technical field of tissue repair.

Description

technical field [0001] The present invention relates to a kind of material that can be used for tissue repairing and its preparation method, relate in particular to a kind of gelatin and mesoporous biological glass composite nano-membrane material and its preparation method, described composite nano-membrane material can be used for wound auxiliary material, blood vessel, nerve, Tissue engineering scaffolds, etc. Background technique [0002] Damage and loss of human tissue can lead to dysfunction. The traditional repair method is autologous tissue transplantation. Although it can achieve satisfactory curative effect, it will cause many complications and additional damage at the expense of autologous healthy tissue. Human organ failure can be cured by drug treatment and temporary replacement therapy. The lives of some patients were saved, but the sources of donor organs were extremely limited, and immunosuppressive agents had to be used for a long time due to immune rejecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/18A61L27/10A61L27/22D04H1/541
Inventor 孙皎周恬莫秀梅
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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