Temperature-sensitive polymer, in-situ gelation temperature-sensitive liquid embolic material and preparation method thereof
A temperature-sensitive, in-situ gel technology, applied in medical science, surgery, etc., to achieve the effect of reducing economic burden, low price, and improving level
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Embodiment 1
[0043] Take 10g of N-isopropylacrylamide for recrystallization treatment; take the treated NIP and butyl methacrylate, react in 50ml of dioxane, stir and blow nitrogen for 10min, then add the initiator azobisiso 0.08 g of butyronitrile, 0.1 g of tetraethylene glycol dimethacrylate as a cross-linking agent, stirred at 60°C and sealed for 6 hours to obtain a temperature-sensitive copolymer.
[0044] The temperature-sensitive copolymer is repeatedly washed in water, purified, and dried; the dried product is dissolved in water for injection with the developer iohexol according to a certain proportion, and sterilized by moist heat to obtain the in-situ gelation temperature. Sensitive liquid embolic material.
Embodiment 2-6
[0045]Embodiment 2-6: The preparation process is exactly the same as that of Embodiment 1.
[0046] The amounts of N-isopropylacrylamide and butyl methacrylate or methyl methacrylate in each example are shown in Table 1 below.
[0047] Each embodiment raw material consumption of table 1
[0048]
[0049] It can be seen from the content in Table 1 that butyl methacrylate and methyl methacrylate are selected to carry out copolymerization reaction with NIP respectively, but methyl methacrylate cannot obtain in-situ gel polymer, although the two are structurally The difference is small, but in this application only butyl methacrylate is suitable. And preferably, the mass ratio of N-isopropylacrylamide to butyl methacrylate is 5:0.1-0.3.
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