A kind of preparation method of silkworm natural gel for medical soft capsule shell

Abstract

The invention discloses a method for preparing silkworm natural gel used in medical soft capsule shells. For all-natural sericin cocoon shells produced from sericin silkworm varieties, a high-molecular-weight sericin solution is extracted by lithium bromide solvent; The sericin solution is quantitatively added with ethanol to obtain a high molecular weight sericin mixed solution; after the sericin gel is immersed in water, the porous sericin gel is prepared by freeze-drying under the coexistence of sericin gel and water, and the prepared high molecular weight sericin gel is The porous sericin gel has small particles, good formability, flexibility, and high elasticity. It not only maintains the original functional properties of natural sericin protein, but also can be combined with other ingredients of medicines and agents without residual risk. The transparency meets the conditions for preparing capsule shells from gelatin, and is a high-quality material for soft capsule shells used in medicine and health food instead of gelatin extracted from animal skin and bones.

Description

Background technique [0001] The invention relates to a method for preparing silkworm natural gel for medical soft capsule shells, belonging to the field of medical materials. Background technique [0002] At present, better capsule shells are made of refined gelatin and auxiliary materials. Gelatin is the main raw material for producing conventional capsule shells, accounting for about 96-99% of capsule shells. Gelatin is a water-soluble protein extracted from the collagen of fresh bones, raw hides, tendons, etc. of animals. Because dry miscellaneous bones and scraps from tanneries cannot be used as raw materials for the production of pharmaceutical gelatin, and foot-and-mouth disease, mad cow disease (BSE), and bird flu are spreading around the world, people are even more concerned about animal bones and skins. Take advantage of the greater fear, thereby limiting the mass production of high-quality gelatin. [0003] Sericin is a natural globular silk protein. Sericin col...

AI Technical Summary

Problems solved by technology

The currently used sericin is sericin recovered from silk reeling aqueous solution. Due to heat, alkali and other reasons, the gelled sericin will be denatured, some functional structures of sericin will be destroyed, and the gel formed by sericin will It has the disadvantages of brittleness and poor formability, and the normal performance of sericin's inherent functional properties is limited