Gelatin hollow capsule

A hollow capsule and gelatin technology, which is applied in the directions of capsule delivery and inactive components of polymer compounds, can solve problems such as poor quality and long production cycle, and achieve the effects of improving quality, improving production efficiency, and improving production technology.

Inactive Publication Date: 2014-12-03
ZHEJIANG YILI CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The quality of traditional gelatin capsules is poor and the production cycle is long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A gelatin hollow capsule, comprising the following components and the mass ratio of each component is: acid method bone gelatin: 20 parts, enzymatic method bone gelatin: 20 parts, polyacrylic acid resin: 20 parts, malt extract: 2 parts, Nepalese Gold preservatives: 0.2 parts, ethanol: 40 parts, carrageenan: 5 parts, triethyl ester: 2 parts, glycerin: 1 part, titanium dioxide: 0.5 parts, magnesium stearate: 1 part, ethylparaben: 0.1 part, methyl p-hydroxybenzoate: 2 parts, methyl silicone oil: 0.2 part, food coloring: 1 part, purified water: 40 parts, the acid-process bone gelatin is made of defatted animal aggregate at a concentration of 5% The temperature of the hydrochloric acid solution is controlled at 15°C. After the pickling, the aggregates are washed 4 times until the residual hydrochloric acid content in the washing water is less than 0.1%, and then the aggregates are transferred to a 600°C Burn in a muffle furnace to finally obtain the finished acid-processed b...

Embodiment 2

[0018] A gelatin hollow capsule, comprising the following components and the mass ratio of each component is: acid method bone gelatin: 25 parts, enzymatic method bone gelatin: 25 parts, polyacrylic acid resin: 25 parts, malt extract: 4 parts, Nepalese Gold preservatives: 0.5 parts, ethanol: 50 parts, carrageenan: 9 parts, triethyl ester: 3 parts, glycerin: 2 parts, titanium dioxide: 0.8 parts, magnesium stearate: 1.5 parts, ethylparaben: 0.2 parts, methyl p-hydroxybenzoate: 3.5 parts, methyl silicone oil: 0.4 parts, food coloring: 2 parts, purified water: 55 parts, the acid method bone gelatin is made of animal aggregate after defatting at a concentration of 5% The temperature of the hydrochloric acid solution is controlled at 15°C. After the pickling, the aggregates are washed 4 times until the residual hydrochloric acid content in the washing water is less than 0.1%, and then the aggregates are transferred to a 600°C Burn in a muffle furnace to finally obtain the finished a...

Embodiment 3

[0020] A gelatin hollow capsule, comprising the following components and the mass ratio of each component is: acid method bone gelatin: 30 parts, enzymatic method bone gelatin: 30 parts, polyacrylic acid resin: 30 parts, malt extract: 6 parts, Nepalese Gold preservatives: 0.8 parts, ethanol: 60 parts, carrageenan: 13 parts, triethyl ester: 5 parts, glycerin: 4 parts, titanium dioxide: 1 part, magnesium stearate: 3 parts, ethylparaben: 0.3 parts, methyl p-hydroxybenzoate: 5 parts, methyl silicone oil: 0.6 parts, food coloring: 3 parts, purified water: 70 parts, the acid method bone gelatin is made of animal aggregate after defatting at a concentration of 5% The temperature of the hydrochloric acid solution is controlled at 15°C. After the pickling, the aggregates are washed 4 times until the residual hydrochloric acid content in the washing water is less than 0.1%, and then the aggregates are transferred to a 600°C Burn in a muffle furnace to finally obtain the finished acid-pr...

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PUM

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Abstract

The invention discloses a gelatin hollow capsule which comprises the following components in parts by mass: 20 to 30 parts of bone gelatin obtained by virtue of an acid method, 20 to 30 parts of bone gelatin obtained by virtue of an enzymatic method, 20 to 30 parts of polyacrylic resin, 2 to 6 parts of malt extract, 0.2 to 0.8 part of a nipagin preservative, 40 to 60 parts of ethyl alcohol, 5 to 13 parts of carrageenan, 2 to 5 parts of triethyl phosphate, 1 to 4 parts of glycerin, 0.5 to 1 part of titanium dioxide powder, 1 to 3 parts of magnesium stearate, 0.1 to 0.3 part of ethylparaben, 2 to 5 parts of methyl 4-hydroxybenzoate, 0.2 to 0.6 part of methyl silicone oil, 1 to 3 parts of food colourants and 40 to 70 parts of purified water. Based on the technical scheme disclosed by the invention, the quality of the gelatin hollow capsule is improved, and the production cycle of gelatin is shortened at the same time, so that a production process is greatly improved.

Description

【Technical field】 [0001] The invention relates to the technical field of hollow capsule formulations, in particular to the technical field of gelatin hollow capsules. 【Background technique】 [0002] Drugs packed in capsules are generally powders or granules that are irritating to the esophagus and gastric mucosa, or drugs that taste bad, are easy to volatilize, are easily decomposed by saliva in the mouth, and are easy to inhale into the trachea. These medicines are packed into capsules, which not only protects the properties of the medicine from being destroyed, but also protects the digestive organs and respiratory tract. Removing the capsule shell may result in drug loss, drug waste, and reduced drug efficacy. In addition, some drugs need to be dissolved and absorbed in the intestines, and the capsule is a kind of protection to protect the drugs from being destroyed by gastric acid. Hollow capsules in medicine refer to capsules made of special film-forming materials (su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42
Inventor 潘银奇
Owner ZHEJIANG YILI CAPSULE
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