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Preparation method of belladonna extract

The technology of belladonna extract and belladonna grass is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc. Low effect, less alkaloid loss and simple process

Inactive Publication Date: 2014-12-03
HUNAN UNIV OF SCI & ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Above-mentioned each method, process is complicated, and the alkaloid extraction that belladonna contains is incomplete, takes a long time, and ethanol consumption is big

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 100 g of belladonna coarse powder, extract three times with a 0.5% dilute sulfuric acid solution as a solvent, add 600 g of dilute sulfuric acid solution each time, and extract for 3 hours. Combine the extracts and concentrate to a relative density of about 1.2. Dissolve 1.5 g of sodium hydroxide in 2 ml of water. Add sodium hydroxide solution and 95% ethanol under stirring until the ethanol concentration reaches 65%. Let stand and take the supernatant. After neutralization with dilute sulfuric acid, it was concentrated under reduced pressure to a thick paste, and dried at low temperature to obtain 8.7 g of solid.

[0016] The content of atropine was determined to reach 2.97% based on atropine sulfate.

Embodiment 2

[0018] Take 100 grams of belladonna coarse powder and extract three times with a 0.3% mass concentration of dilute hydrochloric acid solution as a solvent, add 1000 g of dilute sulfuric acid solution each time, and extract for 3 hours. Combine the extracts and concentrate to a relative density of about 1.3. Dissolve 1 gram of sodium hydroxide in 2 ml of water. Add sodium hydroxide solution and 95% ethanol under stirring until the ethanol concentration reaches 70%. Let stand and take the supernatant. After neutralization with dilute sulfuric acid, it was concentrated under reduced pressure to a thick paste and dried at low temperature to obtain 8.3 g of solid.

[0019] The content of atropine was determined to reach 3.62% based on atropine sulfate.

Embodiment 3

[0021] Take 100 g of belladonna coarse powder, extract three times with a dilute sulfuric acid solution with a mass concentration of 1% as a solvent, add 800 g of dilute sulfuric acid solution each time, and extract for 3 hours. Combine the extracts, concentrate to a relative density of about 1.1, stir 3.5 g of calcium hydroxide to dissolve in 5 ml of water, add calcium hydroxide solution and 95% ethanol under stirring, until the ethanol concentration reaches 60%, let stand and take the supernatant After neutralization with dilute sulfuric acid, it was concentrated under reduced pressure to a thick paste and dried at low temperature to obtain 10.5 g of solid.

[0022] The content of atropine was determined to reach 2.66% based on atropine sulfate.

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Abstract

The invention relates to a preparation method of a traditional Chinese medicine extract, and in particular relates to a preparation method of a belladonna extract. The method comprises the following steps: carrying out reflux extraction on coarse belladonna powder thrice by taking a sulfuric acid aqueous solution as a solvent, concentrating an extracting solution, adding an inorganic base and 95% ethyl alcohol and standing to obtain a supernatant; neutralizing the supernatant with a dilute acid, carrying out reduced pressure concentration on the supernatant until forming a thick paste, thereby obtaining the belladonna extract. The method is simple in process, less in time consumption and low in cost, and ensures that the extraction ratio of alkaloid in belladonna is high and the loss of the alkaloid in an alcohol precipitation process is less. The content of atropine in the prepared belladonna extract is more than 30% higher than that of the atropine prepared in the prior art.

Description

Technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular a preparation method of belladonna extract. Background technique [0002] Belladonna extract obtained by processing belladonna is an anticholinergic drug, which can relieve smooth muscle spasm and inhibit glandular secretion. It is widely used in the treatment of gastric and duodenal ulcers, gastrointestinal, kidney, and biliary colic; The combination of eggplant extract with vitamin U and aluminum hydroxide is a good medicine for treating stomach pain, bloating and gastric acid. [0003] According to "Chinese Pharmacopoeia" (2010 edition, page 397), the preparation method of belladonna extract is: take 1000 g of belladonna coarse powder, use 85% ethanol as solvent, soak for 48 hours, at a speed of 1-3ml per minute Slowly percolate, collect about 3000ml of the initial fluid, save it in another container, continue percolating, until the alkaloid is completel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81
Inventor 姜红宇何福林黄光文湛雪辉
Owner HUNAN UNIV OF SCI & ENG
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