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Preparation method of controlled-release aspirin powder

An aspirin powder and aspirin technology are applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, powder delivery, etc., to achieve the effects of reducing drug side effects and facilitating medication

Inactive Publication Date: 2014-12-10
TIANJIN VOCATIONAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problem that the release speed of the existing hollow nano-silica as the aspirin drug carrier is too fast, and uses nano-silica sol to carry out secondary coating on the loaded aspirin drug, so as to reduce the pore density on the silica shell or reduce the density of the aspirin drug. The pore size on the silicon shell, so as to realize the long-term sustained release and controllable release of aspirin. The technical scheme adopted includes the preparation of hollow nano-silica drug carrier, the loading of aspirin on the drug carrier and the secondary coating of loaded aspirin. The implementation steps are

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Measure 120mL of deionized water and heat it to 80°C. Under vigorous stirring, add 0.6g of geminiquaternary ammonium salt surfactant, add 3ml of concentrated ammonia water to adjust the pH of the solution to greater than 11, add 5mL of ethyl silicate, and react at a constant temperature at 80°C 2h, until complete hydrolysis, then cooling and filtering the precipitate, washing with deionized water, drying at room temperature, placing the sample in a muffle furnace, and calcining at 550°C for 1h to obtain a hollow nano-silica drug carrier sample.

[0017] Weigh 0.20 g of aspirin bulk drug and dissolve in 50 ml of absolute ethanol to obtain aspirin ethanol solution. Immerse 0.5g of hollow silica drug carrier in it, adopt the form of dynamic adsorption, stir or sonicate for 20 minutes, filter after adsorption equilibrium, and the loading mass ratio of drug carrier reaches 50%.

[0018] Dissolve 3.5mL of ethyl silicate in 50mL of absolute ethanol, add 1.5mL of deionized wate...

Embodiment 2

[0020] Measure 120mL of deionized water and heat it to 60°C. Under strong stirring, add 0.6g of geminiquaternary ammonium salt surfactant, add 3ml of concentrated ammonia water to adjust the pH of the solution to greater than 11, add 5mL of ethyl silicate, and react at a constant temperature of 80°C 0.5-2h, until complete hydrolysis, then cooling and filtering the precipitate, washing with deionized water, drying at room temperature, putting the sample in a muffle furnace, and calcining at 550°C for 1-5h to obtain a hollow nano-silica drug carrier sample.

[0021] Weigh 0.20 g of aspirin bulk drug and dissolve in 50 ml of absolute ethanol to obtain aspirin ethanol solution. Immerse 0.5g of hollow silica drug carrier in it, adopt the form of dynamic adsorption, stir for 20 minutes, filter after adsorption equilibrium, and the loading mass ratio of drug carrier reaches 30%.

[0022] Dissolve 3.5mL of ethyl silicate in 50mL of absolute ethanol, add 1.5mL of deionized water and 0....

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Abstract

The invention discloses a preparation method of controlled-release aspirin powder. The preparation method of the controlled-release aspirin powder comprises the steps of preparing a hollow nanosilicon dioxide drug carrier, loading aspirin on the hollow nanosilicon dioxide drug carrier and carrying out secondary coating on the loaded aspirin. The prepared aspirin-loaded drug carrier is immersed in nanosilicon dioxide ethyl alcohol sol, and stirring or ultrasonic treatment is carried out for 0.5-1 hour, so that secondary coating is carried out on the loaded aspirin by virtue of nanosilicon dioxide particles, and the coating thickness is optimized to be 10-20nm; in simulated body fluid, the release rate of the loaded aspirin subjected to the secondary coating in 24 hours is 40-55%, and the release rate of the loaded aspirin subjected to the secondary coating in 48 hours is 70-90%. The preparation method of the controlled release aspirin powder has the advantages that the problem that the existing controlled release aspirin medicine is high in release rate is solved, long-acting controlled release and controlled release can be realized, medication is easy, and the drug side effect is reduced.

Description

technical field [0001] The invention relates to a preparation method of controllable-release aspirin powder, in particular to a preparation method of aspirin powder which uses hollow nano silicon dioxide as a drug carrier to realize long-acting sustained release, and belongs to the fields of fine chemical industry and nanotechnology. Background technique [0002] Aspirin is used to treat colds, fever, headache, toothache, joint pain, and rheumatism. It can also inhibit platelet aggregation. It is used to prevent and treat ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. The recommended dosage is one Take 3-4 times a day. In order to adapt to the modern fast-paced lifestyle, the market needs controlled-release aspirin preparations to facilitate administration and reduce drug side effects. Coating aspirin with a hollow nano-silica carrier is a simple and easy controllable release method. [0003] "Chemical Engineer" magazine, ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/616A61K47/04
Inventor 李建生王丽华贾红钰
Owner TIANJIN VOCATIONAL INST
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