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Method for preparing targeted controlled release aspirin powder

A technology of aspirin powder and aspirin, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the problems of low drug loading and release speed, and achieve reduction of drug side effects and convenience Medication, the effect of improving treatment efficiency

Inactive Publication Date: 2014-12-10
TIANJIN VOCATIONAL INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the problem that when the existing magnetic nano-silica is used as an aspirin drug carrier, the drug-loading amount is too low and the release speed is too fast, and an acid-dissolving method is used to dissolve part of the magnetic core of the magnetic core-shell nano-silica, and the core-shell nano-silica is enlarged. The diameter of the cavity of silica to increase the drug loading capacity; the loaded aspirin drug is coated with polymer sol to reduce the hole density on the silica shell, so as to realize the long-term sustained release and controllable release of aspirin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 0.54 grams of ferric chloride (FeCl 3 6H 2 O) and 0.78 g ferrous ammonium sulfate (NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O), dissolved in 50 ml of deionized water, added to 50 ml of 10% ammonia water under strong stirring, reacted in a water bath at 50°C for 15 minutes, and separated black Fe by magnet attraction 3 o 4 Solid, washed 3-5 times with deionized water to obtain Fe with a particle size of 20-100 nm 3 o 4 Nanocrystalline.

[0018] Measure 120mL of deionized water and heat it to 80°C, under vigorous stirring, add the Fe prepared above 3 o 4 Nano crystals and 0.6g Gemini quaternary ammonium salt surfactant, ultrasonic 10 minutes to obtain Fe 3 o 4 For nanocrystalline sol, add 3ml of concentrated ammonia water to adjust the pH of the solution to be greater than 11, add 10mL of ethyl silicate, and react at a constant temperature at 80°C for 2 hours until it is completely hydrolyzed, then cool and filter the precipitate, and wash with deionized water to obta...

Embodiment 2

[0023] Weigh 0.54 grams of ferric chloride (FeCl 3 6H 2 O) and 0.78 g ferrous ammonium sulfate (NH 4 ) 2 Fe(SO 4 ) 2 .6H 2 O), dissolved in 50 ml of deionized water, added to 50 ml of 10% ammonia water under strong stirring, reacted in a water bath at 50°C for 15 minutes, and separated black Fe by magnet attraction 3 o4 Solid, washed 3-5 times with deionized water to obtain Fe with a particle size of 20-100 nm 3 o 4 Nanocrystalline.

[0024] Measure 120mL of deionized water and heat it to 60°C, under vigorous stirring, add the Fe prepared above 3 o 4 Nano crystals and 0.6g Gemini quaternary ammonium salt surfactant, ultrasonic 10 minutes to obtain Fe 3 o 4 For nanocrystalline sol, add 3ml of concentrated ammonia water to adjust the pH of the solution to be greater than 11, add 10mL of ethyl silicate, and react at a constant temperature at 60°C for 2 hours until it is completely hydrolyzed, then cool and filter the precipitate, and wash with deionized water to obtain...

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PUM

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Abstract

The invention discloses a method for preparing targeted controlled release aspirin powder. The preparation process comprises the following four steps: preparing a magnetic core-shell nano-silica drug carrier, partially dissolving a magnetic core, loading aspirin on the magnetic drug carrier and performing secondary coating of the aspirin. According to the invention, the magnetic core is partially dissolved by adopting an acid-soluble mode, the cavity diameter of the magnetic core-shell nano-silica is enlarged, and the drug loading capacity is improved. The aspirin-loaded drug is subjected to secondary coating by using polyvinylpyrrolidone polymer sol, and the pore density on the silica shell is reduced. The problem that the conventional slow release aspirin drug is extremely high in release speed is solved, and long-lasting release and controlled release can be realized. The drug carrier has magnetic property, the drug can reach the target tissues under guide of a magnetic field, targeted drug delivery is realized, and the treatment efficiency is improved.

Description

technical field [0001] The invention relates to a method for preparing aspirin powder with controllable release, in particular to a method for preparing aspirin powder with magnetic nano-silicon dioxide with a cavity as a drug carrier to realize targeted long-acting sustained release, which belongs to fine chemical industry and nanotechnology field. Background technique [0002] Aspirin is used to treat colds, fever, headache, toothache, joint pain, and rheumatism. It can also inhibit platelet aggregation. It is used to prevent and treat ischemic heart disease, angina pectoris, cardiopulmonary infarction, and cerebral thrombosis. The recommended dosage is one Take 3-4 times a day. In order to adapt to the modern fast-paced lifestyle, the market needs targeted and controlled-release aspirin preparations to facilitate medication, reduce drug side effects and improve therapeutic efficacy. Coating aspirin with magnetic nano-silica carrier is a simple and easy targeted and con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K47/04A61K9/51A61P29/00A61P7/02B82Y5/00
Inventor 李建生贾红钰李无为
Owner TIANJIN VOCATIONAL INST
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