Preparation method of polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles

A composite nanoparticle and nanoparticle technology, which is applied in the field of preparation of polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles, can solve the problems of low drug loading and encapsulation efficiency, long preparation process, etc., and achieve Long-acting sustained release, shortening the preparation process, and improving the effect of drug loading

Active Publication Date: 2020-05-15
TAIYUAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the disadvantages of these methods are that the drug loading and encapsulation efficiency are relatively low, and the preparation process is long.

Method used

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  • Preparation method of polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles
  • Preparation method of polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles
  • Preparation method of polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles

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preparation example Construction

[0027] (1) Preparation of homogeneous suspension

[0028] Weighed 10 mg of dried starch-loaded silver nanoparticles and 10–50 mg of naringenin in 10 mL of ultrapure water, and dispersed them uniformly with an ultrasonic disperser at 300–600 W in an ice-water bath. form a homogeneous suspension;

[0029] (2) Preparation of composite nanoparticles

[0030] Weigh 100-300 mg of polylactic acid, stir and dissolve it in 20-30 mL of acetone, and make a mass concentration of 0.005-0.015 g·mL -1 The solution, the homogeneous suspension obtained in (1) was added dropwise to the polylactic acid acetone solution, and at the same time placed in a high-shear dispersing emulsifier at 3000 r min -1 After 30-60 min, 20-45 mL of ethanol was added dropwise to precipitate polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles;

[0031] (3) Separation of composite nanoparticles

[0032] Add 20 mL of an aqueous solution of a stabilizer with a mass fraction of 0.1% to...

Embodiment 1

[0040] The preparation method of polylactic acid coated naringenin and starch silver-loaded composite nanoparticles comprises the following steps:

[0041] ① Add 0.5 g of soluble starch and 50 mL of ultrapure water into a beaker, heat the above solution to 90 °C, and place it under a stirrer until the starch is completely dissolved, then gradually cool it to 70 °C at room temperature; then put 1 The concentration in mL is 0.1 mol·L -1 The silver nitrate solution was added to the soluble starch solution, and after 10 min, 2.5 mL of 0.1 mol·L -1 Glucose solution, then drop an appropriate amount of 0.5% sodium hydroxide solution or ammonia water, adjust the pH value of the reaction solution to about 8.0, and continue stirring under this condition for 120 min; -1 centrifuged, washed three times with ultrapure water, vacuum-freezed and dried to obtain brown-red starch-loaded silver nanoparticles;

[0042] (1) Preparation of homogeneous suspension

[0043] 10 mg of dried starch-l...

Embodiment 2

[0049] The preparation method of polylactic acid coated naringenin and starch silver-loaded composite nanoparticles comprises the following steps:

[0050] ① Add 0.5 g of soluble starch and 50 mL of ultrapure water into a beaker, heat the above solution to 90 °C, and place it under a stirrer until the starch is completely dissolved, then gradually cool it to 70 °C at room temperature; then put 1 The concentration in mL is 0.1 mol·L -1 The silver nitrate solution was added to the soluble starch solution. After 10 min, 2.5 mL glucose solution with a concentration of 0.1 mol·L-1 was added to the above mixed solution, and then an appropriate amount of sodium hydroxide solution with a concentration of 0.5% or Ammonia, adjust the pH value of the reaction solution to about 8.0, and keep stirring under this condition for 120 min; -1 centrifuged, washed three times with ultrapure water, vacuum-freezed and dried to obtain brown-red starch-loaded silver nanoparticles;

[0051] (1) Prep...

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Abstract

The invention relates to a preparation method of a multifunctional composite antibacterial material, in particular to a preparation method of a polylactic acid-coated naringenin and starch silver-loaded composite nano particle with antibacterial, antioxidant and long-acting slow release properties. The preparation method adopts a solvent / anti-solvent method and combines with a freeze drying technology, and naringenin and starch silver-loaded nano particle are encapsulated by using polylactic acid or lactide and a copolymer of other monomers as carriers, so that a naringenin and starch silver-loaded composite nano particle coated by the polylactic acid or lactide and the copolymer of other monomers is prepared, the drug loading ratio of the composite nano particle reaches more than 30%, encapsulation efficiency reaches more than 90%, and drug release time is longer than 180 hours; and the composite nano particle can solve the defects of a silver-loaded nano particle and can reduce oxidative damage and toxic and side effects which are produced by active oxygen, long-acting slow release of small molecules can be realized through degradation of polylactic acid and a copolymer thereof,and the composite nano particle also has prolonged antibacterial and antioxidant effects.

Description

technical field [0001] The invention relates to a preparation method of a multifunctional composite antibacterial material, in particular to a preparation method of polylactic acid-coated naringenin and starch-loaded silver composite nanoparticles with antibacterial, anti-oxidation and long-acting slow-release properties. Background technique [0002] Bacteria and other pathogenic microorganisms are ubiquitous in our lives and affect human health all the time. They have aroused great concern in food, clinic, medicine and other aspects. Therefore, the research of antibacterial materials is of great significance. Using antibacterial materials to inhibit the growth and reproduction of harmful bacteria is an important means to improve human health. [0003] The use of antibiotics has played an effective role in the fight against bacteria. However, the emergence of pathogens with multi-drug resistance to traditional antibiotics has made it an urgent problem to find alternative an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K47/34A61K33/38A61P39/06A61P31/04A61K31/352
CPCA61K9/0002A61K9/5031A61K31/352A61K33/38A61K2300/00
Inventor 王慧芳牛宝龙郭睿劼高向华王斌王飞
Owner TAIYUAN UNIV OF TECH
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