Dopamine-based method for improving surface hydrophilicity and biocompatibility of medical polyurethane material

A polyurethane material and biocompatibility technology, applied in the field of medical polymer materials, can solve unreached problems, achieve good stability, eliminate toxic by-products, and improve blood compatibility

Inactive Publication Date: 2014-12-10
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although the polyurethane material itself has good blood compatibility, it has not yet reached a very satisfactory level. In order to further improve the hydrophilicity and biocompatibilit

Method used

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  • Dopamine-based method for improving surface hydrophilicity and biocompatibility of medical polyurethane material
  • Dopamine-based method for improving surface hydrophilicity and biocompatibility of medical polyurethane material
  • Dopamine-based method for improving surface hydrophilicity and biocompatibility of medical polyurethane material

Examples

Experimental program
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Effect test

Embodiment 1

[0039] A Tris-HCl solution with a pH of 8.5 and a 10wt% dopamine solution were prepared, and 20 g of the Tris-HCl solution and 0.040 g of the dopamine solution were uniformly mixed to obtain a mixed solution. Take a medical polyurethane film material of appropriate size and ultrasonically wash it several times, then vacuum-dry it, then add it to the above mixed solution, seal it with plastic cling film, and place it at room temperature for 24 hours, then take it out, wash it, and dry it in vacuum to obtain a dopamine-modified medical polyurethane film material . Add distilled water, acrylic acid, nitric acid, and ammonium cerium nitrate sequentially into a 100ml three-neck flask, mix well to obtain a hydrophilic film stock solution, and pass nitrogen gas to remove oxygen. Afterwards, the dopamine-modified medical polyurethane film material was added to the hydrophilic film stock solution from which oxygen was removed, and reacted with magnetic stirring at 60° C. for 4 hours in...

Embodiment 2

[0044] Tris-HCl solution with pH 7.5 and 0.05wt% dopamine solution were prepared, and 18g Tris-HCl solution and 0.036g dopamine solution were uniformly mixed to obtain a mixed solution. Take a medical polyurethane film material of appropriate size and ultrasonically wash it several times, then vacuum-dry it, then add it to the above mixed solution, seal it with plastic cling film, treat it with 15W ultrasonic wave at room temperature for 8 hours, then take it out, wash it, and vacuum-dry it to obtain a dopamine-modified medical polyurethane film material. Add distilled water, acrylic acid, nitric acid, and ammonium cerium nitrate sequentially into a 100ml three-neck flask, mix evenly to obtain a hydrophilic film stock solution, and pass through nitrogen to remove oxygen. Afterwards, the dopamine-modified medical polyurethane film material was added to the hydrophilic film stock solution from which oxygen was removed, and the reaction was performed under magnetic stirring at 60...

Embodiment 3

[0048] A Tris-HCl solution with a pH of 9.5 and a 20wt% dopamine solution were prepared, and 22g of the Tris-HCl solution and 0.040g of the dopamine solution were evenly mixed to obtain a mixed solution. Take a medical polyurethane film material of appropriate size and ultrasonically wash it several times, then vacuum-dry it, then add it to the above mixed solution, seal it with plastic cling film, and place it at room temperature for 12 hours, then take it out, wash it, and dry it in vacuum to obtain a dopamine-modified medical polyurethane film material . Add distilled water, acrylamide, and ammonium cerium nitrate sequentially into a 100ml three-neck flask, mix evenly to obtain a hydrophilic film stock solution, and pass nitrogen gas to remove oxygen. Afterwards, the dopamine-modified medical polyurethane film material was added to the hydrophilic film stock solution from which oxygen was removed, and the reaction time was 4 hours under magnetic stirring at 90° C. in a nitr...

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Abstract

The invention discloses a dopamine-based method for improving surface hydrophilicity and biocompatibility of a medical polyurethane material. The method comprises the following steps: carrying out pretreatment on a medical polyurethane material by using dopamine so as to obtain a site with proper surface roughness and abundant reaction activity; putting the medical polyurethane material subjected to dopamine pretreatment into hydrophilic membrane concentrate, and carrying out heating reaction for 4-8 hours; and fully cleaning and drying the reaction product. According to the method disclosed by the invention, a layer of film is prepared on the material surface on the basis of the dopamine, and the prepared film has high hydrophily, the blood compatibility can be improved, the damage to tissue is reduced, the film has good stability, and low water contact angle and high hydrophily of a sample can be kept for a long period of time.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a method for improving the surface hydrophilicity and biocompatibility of medical polyurethane materials based on dopamine. Background technique [0002] Polyurethane is one of the medical polymer materials widely used in the human body. It has excellent physical and mechanical properties such as good wear resistance and elasticity, and biocompatibility with antithrombotic and low toxicity properties, ensuring the safety of its application in medical materials. sex. [0003] In the 1950s, polyurethane was first used in biomedicine as a fracture repair material; shortly thereafter, it was successfully used as a supplementary coating for sutures in vascular surgery. Polyurethane began to receive more and more attention as a medical material in the 1970s. After entering the 1980s, due to the success of the artificial heart made of polyurethane material in the tra...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08J7/16C08J7/06C08L75/04
Inventor 周雪锋钱玲顾宁潘雪张天柱
Owner SOUTHEAST UNIV
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