Zinc gluconate oral solution and preparation method thereof

A technology of zinc gluconate oral liquid and zinc gluconate, which is applied in the field of medicine to achieve the effects of improving bioavailability, improving stability, improving clarity and stability

Inactive Publication Date: 2014-12-24
哈药集团人民同泰医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of domestic technology and research and development level in the early years, there is still a lot of room for optimization in formula, production process and product quality

Method used

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  • Zinc gluconate oral solution and preparation method thereof
  • Zinc gluconate oral solution and preparation method thereof
  • Zinc gluconate oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Formula

[0019]

[0020] (2) Preparation process

[0021] Take 63% of the volume of pure water, heat to boil, add 3.0g of zinc gluconate under stirring, dissolve to boil, add 120g of white sugar, boil, add 0.4g of casein phosphopeptide, stir to dissolve evenly, adjust with citric acid pH value, add helium gas, add 0.22mL lychee essence, stir and circulate evenly, and add pure water to the full amount of the solution, after stirring, measure the zinc content of the semi-finished product to 39.38mg / 100ml, and filter it with a 5μm filter material after passing the test. Potting, sterilizing at 100°C for 30 minutes, light inspection, and packaging.

Embodiment 2

[0023] (1) Formula

[0024]

[0025] (2) Preparation process

[0026] Take 68% of the volume of pure water, heat to boil, add 3.3g of zinc gluconate under stirring, dissolve to boil, add 140g of white sugar, boil, add 0.6g of casein phosphopeptide, stir to dissolve evenly, adjust with citric acid pH value, add helium gas, add 0.18mL peach essence, stir and circulate evenly, and add pure water to the full amount of the solution, after stirring, measure the zinc content of the semi-finished product to 41.05mg / 100ml, and filter it with a 15μm filter material after passing the test , potting, sterilized at 100°C for 50 minutes, light inspection, and packaging.

Embodiment 3

[0028] (1) Formula

[0029]

[0030]

[0031] (2) Preparation process

[0032] Take 65% of the volume of pure water, heat to boil, add 3.0g of zinc gluconate under stirring, dissolve to boil, add 150g of white sugar, boil, add 0.5g of casein phosphopeptide, stir to dissolve evenly, adjust pH with lactic acid value, feed nitrogen, add 0.20mL strawberry essence, stir and circulate evenly, and add pure water to the full amount of the solution, after stirring, measure the zinc content of the semi-finished product to 38.28mg / 100ml, filter it with a 1μm filter material after passing the test, and potting , 100 ℃, 40 minutes of sterilization, lamp inspection, packaging.

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PUM

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Abstract

The invention provides a zinc gluconate oral solution and a preparation method thereof. Every 1000mL of oral solution is prepared from 2.5-3.5g of zinc gluconate, 100-200g of white granulated sugar, 0.1-1.3g of casein phosphopeptides and 0.10-0.30mL of essence. The preparation method comprises the following steps: by using the above components as raw and auxiliary materials, dissolving; preparing; filtering; filling; carrying out flowing steam sterilization; packaging and the like. Compared with the conventional formula, in a novel formula, the casein phosphopeptide is added as an absorption promoter to effectively promote the human body to absorb and utilize zinc, so that absorption utilization ratio of zinc is improved. Meanwhile, the oral solution dosage is adopted, so that the bioavailability is further improved. The casein phosphopeptide is free from safety problem and easily accepted by people and is good in stability. The food with the casein phosphopeptide maintains the original flavor and taste. Compared with the conventional process, the novel process is used for effectively improving the clarity and stability of the finished product.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a formulation of zinc gluconate oral liquid and a preparation method thereof. Background technique [0002] Zinc gluconate oral liquid is a health food made of zinc gluconate with high bioavailability, safety, and no irritation to the gastrointestinal tract as raw material, purified water, white sugar, and essence as auxiliary materials. It has the health function of zinc supplementation. This product is an oral liquid dosage form, without the disintegration and release process of tablets, and can be quickly absorbed and utilized by the human body. Studies have shown that the half-life of the blood concentration of the oral liquid made of zinc gluconate is about twice that of the tablet, and the relative availability is 138.11%. After oral administration, zinc gluconate is mainly absorbed in the small intestine and can rapidly increase the concentration of zinc ions in serum. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/42A61K31/315A61P3/12
Inventor 刘春凤刘占滨吕艳春金焱
Owner 哈药集团人民同泰医药股份有限公司
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