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Compound for treating animal diseases and application thereof

A compound and animal technology, applied in the field of compounds for the treatment of animal diseases, can solve the problems of large losses of dairy farmers and antibiotic resistance, and achieve the effects of low therapeutic dose, good therapeutic effect and short duration of use

Inactive Publication Date: 2017-05-24
SICHUAN AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a solution for the current problems that mastitis seriously restricts the development of the dairy industry, and the existing antibiotics will remain in dairy products, resulting in large losses for dairy farmers, and the existing antibiotics still have drug resistance. A compound for treating animal diseases and its application

Method used

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  • Compound for treating animal diseases and application thereof
  • Compound for treating animal diseases and application thereof
  • Compound for treating animal diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 pharmaceutical synthesis technique and preparation

[0031] 1) Synthesis process

[0032]Weigh 10.8 g (0.1 mol) of o-phenylenediamine, measure 10 mL of propionic acid and an appropriate amount of 10% hydrochloric acid, and add them into a round bottom flask in sequence. Then, connect the round-bottomed flask to the condensing reflux tube, fix it with an iron stand, connect it to a 60°C hot water bath, and heat it for 1 hour. After cooling, take out the round-bottom flask, pour the obtained reaction product into a beaker and let it stand for 8 hours, filter it with a funnel with a gauze core, drain it and rinse it twice with distilled water. After the obtained product was dried in a fume hood, 11.6 g of colorless fine block crystals of 2-ethylbenzimidazole were obtained, with a yield of 78%.

[0033] 2) Preparation of triiodobenzimidazole

[0034] Weigh 8g of 2-ethylbenzimidazole, 41g of iodine, 5g of calcium carbonate, 5g of potassium iodide, measure 300...

Embodiment 2

[0035] The stability of embodiment 2 preparations

[0036] Take 2-ethyl-4,5,6-triiodobenzimidazole and 1,3-diethyl-4,5,6-triiodobenzimidazole respectively, and prepare 1% mass percent sterile solutions respectively , recorded as Experiment 1 to Experiment 2 in turn. Taking 2-ethyl-4,5,6-triiodobenzimidazole as an example, it was prepared into a sterile solution with a mass percentage of 1%, which was recorded as experimental sample 1.

[0037] It has been proved that when the pH value of the test product is 6-8, the chemical properties are stable under dark conditions; after being placed for a long time under normal light conditions, the addition of starch turns blue; when the pH value is 1-2, the addition of starch turns blue ; When hydrogen peroxide is added to it, the addition of starch turns blue.

[0038] Take experimental product 1 as an example for further explanation. Its pH value should be controlled within the range of 6-8. When the pH is 7, it should be sealed in ...

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Abstract

The invention discloses a compound for treating animal diseases and the application of the compound, and aims to solve the problems that bovine mastitis seriously restricts the development of the dairy industry at present, existing antibiotics are reserved in dairy products and cause relatively large losses to dairy farmers, and the existing antibiotics commonly have antibiotic resistance. The compound is 1,3-R biradical iodobenzimidazole or 2-R radical iodobenzimidazole, and the R radical can be C1-C20 alkyl radical. Reality testing shows the compound has the advantages of definite and stable curative effect, short course of treatment, low possibility of relapse after curing, no economic losses, high drug safety, no requirement for a non-milking period, low possibility of drug resistance generation of bacteria, and the like when being used for treating bovine mastitis. When the compound is used for treating bovine mastitis, a relatively good curative effect can be achieved, and the market prospect is broad. Besides, the compound provided by the invention further can be used for treating animal pneumonia and other inflammation, as well as diarrhea and other diseases, and has relatively good technical effect and relatively high application value.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound for treating animal diseases and its application. The invention can be used to treat inflammations such as animal mastitis and pneumonia, and diseases such as diarrhea, and can effectively protect the health of livestock and poultry. Background technique [0002] With the improvement of people's living standards in our country and the improvement of dietary structure, people's demand for high-nutrition food is increasing, especially for fresh milk and dairy products. The protein in milk can promote the growth of children. At the same time, the calcium in milk can supplement calcium for the elderly. Yogurt can regulate the digestive function of the gastrointestinal tract. Milk is also rich in beneficial vitamins, which play an important role in human health. . The increasing demand for fresh milk and dairy products has laid a good market foundation for the developme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4184A61K47/69A61P29/00A61P1/12A61P15/14A61P11/00A61P31/00
Inventor 崔恒敏叶平李英伦邹平陈放
Owner SICHUAN AGRI UNIV
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