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Compound doxycycline antibacterial medicine

A doxycycline and antibacterial drug technology, applied in the field of medicine, can solve the problems of slow drug dissolution rate, poor bioavailability, incomplete absorption, etc., and achieve the effects of improving bioavailability, taking convenience, and stabilizing drug efficacy

Inactive Publication Date: 2015-01-14
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although oral doxycycline can be absorbed by the gastrointestinal tract, the absorption is not complete, and due to the slow dissolution rate of the drug, the bioavailability is poor
However, the effect of the water extract of Astragalus membranaceus is relatively slow, and the effect of using it alone is not ideal.

Method used

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  • Compound doxycycline antibacterial medicine
  • Compound doxycycline antibacterial medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A compound doxycycline antibacterial drug, its dosage form is nanoemulsion, the weight part of nanoemulsion is composed of: astragalus water extract is 5.3 parts, castor oil polyoxyethylene ether 40 (surfactant) 28 parts, ethanol (surfactant) active agent) 3 parts, doxycycline 7.2 parts, isopropyl myristate (oil) 14 parts, distilled water 42.5 parts.

[0031] Accurately weigh castor oil polyoxyethylene ether 40 28g, ethanol 3g, doxycycline 7.2g, isopropyl myristate 14g, stir evenly at room temperature (25°C), and then slowly drop into it the dissolved astragalus water extract The distilled water of product, along with the increase of aqueous solution of Radix Astragali, the viscosity of system increases, when adding the amount of aqueous solution of Radix Astragali to make the system change from water-in-oil to oil-in-water nanoemulsion, the viscosity of system changes from The most viscous state becomes thinner, and what is produced at this time is the colorless and tr...

Embodiment 2

[0033] A compound doxycycline antibacterial drug, its dosage form is nanoemulsion, the weight part of nanoemulsion is composed of: astragalus water extract is 6.8 parts, castor oil polyoxyethylene ether 40 (surfactant) 25 parts, 1,2- Propylene glycol (cosurfactant) 10 parts, doxycycline 4.5 parts, ethyl oleate (oil) 10 parts, distilled water 43.7 parts.

[0034] Its preparation method refers to embodiment 1.

Embodiment 3

[0036] A compound doxycycline antibacterial drug, its dosage form is nanoemulsion, the weight part of nanoemulsion is composed of: astragalus water extract is 4.5 parts, polyoxyethylene 40 hydrogenated castor oil (surfactant) 30 parts, glycerol ( co-surfactant) 11 parts, doxycycline 5.5 parts, linoleic acid (oil) 13 parts, distilled water 36 parts.

[0037] Its preparation method refers to embodiment 1.

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Abstract

The invention belongs to the technical field of medicines, and provides a compound doxycycline antibacterial medicine. The effective component of the medicine prepared from astragalus membranaceus aqueous extract and doxycycline is an oil-in-water type nano-emulsion, and the nano-emulsion is prepared from the following components in parts by weight: 1-20 parts of an astragalus membranaceus aqueous extract, 15-40 parts of a surfactant, 1-20 parts of co-surfactant, 1-25 parts of doxycycline, 1-20 parts of oil and 20-70 parts of distilled water. The nano-emulsion has the advantages of uniformly distribution, transparent system, high stability, relatively low surface tension, excellent mobility and convenience in taking, can be quickly swallowed by reticuloendothelial cells after being administrated, so that the medicine can quickly take effect, constant plasma concentration and pharmacological effect can be maintained, the bioavailability of the medicine can be improved, the drug effect can be enhanced, the using amount and using frequency of the medicine can be reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a compound doxycycline antibacterial drug. Background technique [0002] Doxycycline, alias: doxycycline (Doxycycline), deoxyoxytetracycline, long-acting oxytetracycline, is mainly used to treat respiratory tract, urinary tract and biliary tract infections caused by sensitive bacteria. The antibacterial spectrum is basically the same as that of tetracycline and oxytetracycline, and its antibacterial activity in vivo and in vitro is stronger than that of tetracycline. Microorganisms have close cross-resistance to this product and tetracycline, oxytetracycline, etc. Oral absorption is good. It is mainly used for upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, senile chronic bronchitis, etc. caused by sensitive gram-positive bacteria and gram-negative bacilli. disease, mycoplasma pneumonia, etc. It can also be used...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K36/481A61P31/04A61K31/65
Inventor 孙江宏阮心洁
Owner HENAN SOAR VETERINARY PHARMA
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