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Method for extracting high-purity piperine with low pollution

A piperine, low pollution technology, applied in the direction of organic chemistry, can solve problems such as environmental pollution, human injury, etc., achieve high purity, high extraction rate, and overcome the effects of pollution

Inactive Publication Date: 2015-01-28
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the previous solvent extraction method used toxic organic solvents such as methanol and chloroform with strong solubility, which caused serious harm to the human body and environmental pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The present invention will be further described in detail below in conjunction with examples of implementation.

[0017] (1) Grind the pepper fruit into 60-mesh pepper powder, add it to 95% ethanol solution, the solid-to-liquid ratio is 1:4, soak it for 0.5h, put it in a water bath at 80°C and reflux for 2h, and collect the filtrate and filter residue by suction filtration ;

[0018] (2) The obtained filtrate is concentrated by distillation under reduced pressure, and the filtrate is concentrated to 1 / 5-1 / 4 of the volume of the original solution;

[0019] (3) Soak the obtained filter residue with 95% ethanol for 0.5h, the solid-to-liquid ratio is 1:3, and reflux and suction filtration collect the filtrate again, and the reflux condition is the same as in step (1);

[0020] (4) two parts of filtrates are combined and concentrated by distillation under reduced pressure, and the filtrate is concentrated to 1 / 5-1 / 4 of the volume of the original solution to obtain a concent...

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Abstract

The invention discloses a method for extracting piperine with low pollution, and in particular relates to a method for extracting and purifying piperine by using low-toxic organic solvents including ethanol and acetone. The method comprises the steps of extracting piperine by adopting a reflux method and using nontoxic ethanol as a solvent, adjusting the pH value through hydrochloric acid, removing piperic acid, neutralizing redundant acid by using sodium hydroxide, adding distilled water, sufficiently cooling to obtain crude piperine, performing re-crystallization purification by using low-toxic acetone as a solvent, and performing vacuum drying to obtain high-purity piperine. The method overcomes the defects of common toxic solvents such as methanol and chloroform in traditional extraction methods and the defect of pollution to a water environment in an acid extraction method. Moreover, the method has the advantages of high extraction rate, high purity, low production cost, low pollution, simple production process and the like, and the obtained piperine product is high in activity, purely natural and high in medical value.

Description

technical field [0001] The invention discloses a method for extracting high-purity piperine with low pollution, in particular to a method for extracting and purifying piperine using low-toxic organic solvents such as ethanol and acetone as solvents. Background technique [0002] Due to its unique effects such as antibacterial and insecticidal, anti-oxidation, diarrhea, anti-depression, immune enhancement and anti-cancer, piperine has strong activity and great medicinal value. The main components in the pepper fruit are alkaloids, volatile oils, proteins, resin oils, mineral components and starch, so the method of extracting and separating high-content and high-activity piperine components from pepper is widely studied. At present, the methods for extracting piperine include solvent extraction, acid water extraction, ultrasonic extraction, microwave extraction, supercritical fluid carbon dioxide extraction and ultrasonic ionic liquid extraction. Among them, solvent extractio...

Claims

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Application Information

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IPC IPC(8): C07D317/60
CPCC07D317/60
Inventor 李鑫曹华茹陈亮鲁燚羊梦诗
Owner ZHEJIANG FORESTRY UNIVERSITY