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Fluoroquinolone substitute template molecularly imprinted polymer and application thereof

A technology of fluoroquinolones and substitute templates, applied in ion exchange, other chemical processes, ion exchange regeneration, etc., to achieve high specific selectivity, ultra-high specific selectivity, and reduce matrix interference

Active Publication Date: 2015-02-11
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current literature reports, there is no report on the preparation of molecularly imprinted polymers of fluoroquinolone antibiotics using daidzein as an alternative template and their use in solid-phase extraction of fluoroquinolones in biological samples or food

Method used

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  • Fluoroquinolone substitute template molecularly imprinted polymer and application thereof
  • Fluoroquinolone substitute template molecularly imprinted polymer and application thereof
  • Fluoroquinolone substitute template molecularly imprinted polymer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Dissolve 1 mmol of the surrogate template molecule daidzein into dimethyl dimethacrylate containing 4 mmol of the functional monomer 4-vinylpyridine, 20 mmol of the crosslinker ethylene glycol dimethacrylate and 0.04 g of the initiator azobisisobutyronitrile Prepare a pre-polymerization solution in sulfoxide + acetonitrile (1+2) (5.6mL), place the pre-polymerization solution in an ice bath for 10-15min and mix it with ultrasound, then pass nitrogen for 10min to remove the oxygen in the system, seal it and put it in 4 ℃ for 2 hours, and then placed at 60 ℃ for 24 hours. The white massive polymer produced by the reaction is pulverized, ground, sieved and settled to obtain a polymer with a particle size of 45-63 μm. The obtained polymer was sequentially Soxhlet-extracted using methanol acetic acid (9:1, v / v) and methanol as extraction solvents to remove template molecules and interfering substances, and the obtained polymer was dried overnight in a vacuum oven at 60°C A w...

Embodiment 2

[0029]Dissolve 1 mmol of the surrogate template molecule daidzein into dimethyl dimethacrylate containing 4 mmol of the functional monomer 4-vinylpyridine, 20 mmol of the crosslinker ethylene glycol dimethacrylate and 0.04 g of the initiator azobisisobutyronitrile Prepare a pre-polymerization solution in sulfoxide (5.6mL), place the pre-polymerization solution in an ice bath for 10-15min and mix it with ultrasound, then pass nitrogen gas for 10min to remove the oxygen in the system, seal it and place it in a refrigerator at 4°C for 2h, then Placed at 60°C for 24h. The white massive polymer produced by the reaction is pulverized, ground, sieved and settled to obtain a polymer with a particle size of 45-63 μm. The obtained polymer was sequentially Soxhlet-extracted using methanol acetic acid (9:1, v / v) and methanol as the extraction solvent to remove template molecules and interfering substances, and the obtained polymer was dried overnight in a vacuum oven at 60°C A white mole...

Embodiment 3

[0032] Dissolve 1 mmol of the surrogate template molecule daidzein into dimethyl dimethacrylate containing 4 mmol of the functional monomer 4-vinylpyridine, 20 mmol of the crosslinker ethylene glycol dimethacrylate and 0.04 g of the initiator azobisisobutyronitrile Prepare a pre-polymerization solution in formamide + acetonitrile (1+2), place the pre-polymerization solution in an ice bath for 10-15 minutes and mix it with ultrasound, then pass nitrogen for 10 minutes to remove oxygen in the system, seal it and store it in refrigeration at 4°C 2h, and then placed at 60°C for 24h. The white massive polymer produced by the reaction is pulverized, ground, sieved and settled to obtain a polymer with a particle size of 45-63 μm. The obtained polymer was subjected to Soxhlet extraction using methanol / acetic acid (9:1, v / v) and methanol as extraction solvents in order to remove template molecules and interfering substances, and the obtained polymer was dried in a vacuum oven at 60°C ...

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Abstract

The invention provides a preparation method and an application method of a fluoroquinolone antibiotic medicine substitute template molecularly imprinted polymer. According to the invention, substitute template molecules, a cross-linking agent, a functional monomer, and an initiator are dissolved in a pore-forming solvent, such that a pre-polymerization solution is prepared; a polymerization reaction is carried out for 24-48h under a temperature of 50-70 DEG C; a white block-shaped polymer obtained in the polymerization reaction is ground, sieved, and settled, such that polymer particles with a particle size of 45-63[mu]m are obtained; the obtained polymer is subjected to Soxhlet extraction or ultrasonic extraction sequentially by using methanol / acetic acid and methanol as extraction solvents, such that residual substitute template molecules and interfering substances are removed, and the substitute template molecularly imprinted polymer is obtained. The substitute template molecularly imprinted polymer has high specific selectivity and enrichment capability upon fluoroquinolone antibiotics. With the material, an imprinting effect is ensured, and a template leakage problem is solved. The polymer can be used in separation, enrichment and purification of fluoroquinolone antibiotics in complex substrate.

Description

technical field [0001] The invention relates to an alternative template molecular imprinted polymer for selectively enriching and purifying fluoroquinolone antibiotics, as well as its preparation and application, and belongs to the fields of environmental monitoring and new materials. Background technique [0002] As a new type of pollutant, fluoroquinolones (FQs) widely exist in water and food, and have aroused widespread concern in the society. FQs drugs are artificially synthesized broad-spectrum antimicrobials, commonly including norfloxacin, ofloxacin, ciprofloxacin, enrofloxacin, danofloxacin, sarafloxacin and difloxacin, etc. 4 kinds are special drugs for veterinary animals. The extensive use and abuse of FQS has led to the continuous infusion of such substances and their metabolites into the water environment, and the formation of general accumulation and migration, which poses unpredictable potential risks to human health. Schwarzen-bach et al. said that micro-pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F222/20C08F212/36C08F226/06C08F220/06C08F220/56C08J9/28C08J9/26B01J20/26B01J20/30B01D15/08G01N1/40
Inventor 陈吉平孙晓丽王金成
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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