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Sterilization method for improving synostosis of SLA implant

A technology of osseointegration and sterilization method, which is applied in the field of surgical implants, can solve the problems that the surface wettability of SLA implants cannot be improved, harmful residues, and the surface wettability of SLA implants will not be improved. To achieve the effect of improving surface energy and biological activity, short treatment cycle, and improving interaction

Active Publication Date: 2015-02-18
JIANGSU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the surface wettability of SLA implants will not be improved after sterilization, as document 2 (The roles of titanium surface micro / nanotopography and wettability on the differential response of human osteoblast lineage cells, Acta Biomaterialia, 9(4):6268–6277) reported that at 121°C, the surface contact angle of SLA implants after steam sterilization was as high as 157°, showing strong hydrophobicity.
Other sterilization methods such as γ-ray irradiation cannot improve the surface wettability of SLA implants, and the management of radiation sources is very strict
In addition, the ethylene oxide sterilization method may result in harmful residues
To sum up, there is currently no method that can efficiently and comprehensively improve the wettability of SLA implants while sterilizing. In view of this, it is necessary to invent a new sterilization method

Method used

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  • Sterilization method for improving synostosis of SLA implant
  • Sterilization method for improving synostosis of SLA implant
  • Sterilization method for improving synostosis of SLA implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The implants are made of pure titanium with an SLA surface. After testing, the contact angle of distilled water on the surface of the SLA implant before sterilization is 143.5°, as figure 1 shown.

[0019] First, the above-mentioned SLA implant can be cleaned, specifically: ultrasonically clean the SLA implant in absolute ethanol and ultrapure water (18MΩ*cm), and the cleaning time should be controlled at about 10 minutes. Of course, ultrapure water Distilled or deionized water can be substituted. Next, transfer the implant to a 250ml airtight container, add 150ml of ultrapure water as a sterilizing medium for wetting the implant, wherein the ultrapure water can be replaced by distilled water, normal saline or low-concentration calcium chloride solution etc., can play a good wetting effect; in addition, the container can be an inorganic material with a screw, stainless steel or titanium, etc. Tighten the lid of the container and turn it around again (that is, the lid...

Embodiment 2

[0030] The treatment steps are basically the same as in Example 1, except that the implant is a Ti6Al4V alloy implant with an SLA surface (after testing, the contact angle of distilled water on the surface of the SLA implant before sterilization is 142°), The sterilization temperature is 130°C, and the sterilization time is 10 minutes.

[0031] After testing, the contact angle of distilled water on the surface of the SLA implant after sterilization treatment is 0°, which shows that the method of this embodiment can realize the superhydrophilization of the surface of the SLA implant.

Embodiment 3

[0033] The processing steps are basically the same as in Example 1, except that the implant is made of pure titanium with an SLA surface (after testing, the contact angle of distilled water on the surface of the SLA implant before sterilization is 139° ), the sterilization temperature is 140°C, and the sterilization time is 5 minutes.

[0034] After testing, the contact angle of distilled water on the surface of the sterilized SLA implant is 0°, which shows that the method of this embodiment can realize the superhydrophilization of the surface of the SLA implant.

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Abstract

The invention discloses a sterilization method for improving synostosis of an SLA implant. The sterilization method comprises the following steps: putting the SLA implant into a sealed container, adding water or an aqueous solution serving as a sterilization medium, enabling the water or the aqueous solution to immerse the implant, packaging an aluminum foil on the surface of a cover when the cover of the container is approximately sealed, then putting the container in a pressure steam sterilization device for sterilization, sealing the cover of the container in the pressure steam sterilization device after the sterilization, and taking out the container. The sterilization method has the advantages that the purpose of sterilizing the SLA implant is fulfilled, the wettability of the implant is improved, the mutual action of the implant material and a cell is improved, then the bone cell is more rapidly adhered, spread, propagated, proliferated and differentiated on the surface of the implant, so that the surface energy and the biological activity of the SLA implant are improved, and the bonding strength between the implant and the natural bone is improved. Meanwhile, the method is simple to operate, conventional sterilizing installation is used, the processing cycle is short, and the method is suitable for clinical application.

Description

technical field [0001] The invention relates to a sterilization method, in particular to a sterilization method for improving the osseointegration ability of a sandblasting-acid-etched surface (SLA) implant, and belongs to the technical field of surgical implants. Background technique [0002] SLA technology is the most mature implant surface treatment technology in the world, which can effectively improve surface biocompatibility, promote new bone formation, and enhance the bonding strength between implant and bone. Therefore, SLA implant is the most widely used in clinical practice. Class implants. However, the surface wettability of SLA implants gradually degrades with time during storage, and the contact angle with distilled water can reach up to 140°C, showing severe hydrophobicity. This is not conducive to the adhesion and spreading of osteoblasts on the surface, and it will delay the proliferation and differentiation of cells, resulting in a decrease in the amount of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/07
Inventor 史兴岭徐玲利周广宏
Owner JIANGSU UNIV OF SCI & TECH
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