Saccharide-derived flavor-enhancing humectant Mal-Pro for cigarettes, and preparation method and application thereof
A mal-pro, sugar derivative technology, applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., to achieve high yield, reduce irritation and impurities, and have obvious effects
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Embodiment 1
[0028] A preparation method of sugar derivative tobacco flavoring and moisturizing agent Mal-Pro, which comprises the following steps:
[0029] Add 1 gram of maltose, 0.7 mL of dimethylformamide, and 1.5 mL of anhydrous methanol into a three-neck flask equipped with a thermometer and a condenser tube, reflux at 73°C for 10 minutes, then add 0.128 grams of proline and reflux for 10 minutes again, and finally Add 0.02 g of strong acidic ion exchange resin and 0.018 g of myricetin for reflux reaction for 2 h. After the reaction was completed, 0.457 g of the target product in the form of white crystals was obtained by silica gel column chromatography and recrystallization. Among them, the eluent used for column chromatography separation is a mixed solution composed of n-butanol, glacial acetic acid and water, the volume ratio of the three is 4:2:1, and the chromogenic agent is ninhydrin ethanol solution; the solvent used for recrystallization It is a mixed solution of absolute et...
Embodiment 2
[0031] A preparation method of sugar derivative tobacco flavoring and moisturizing agent Mal-Pro, which comprises the following steps:
[0032] Add 1 gram of maltose, 1.0 mL of dimethylformamide, and 1.5 mL of anhydrous methanol into a three-necked flask equipped with a thermometer and a condenser, and reflux at 80°C for 20 minutes, then add 0.32 grams of proline and reflux for another 20 minutes, and finally Add 0.03 g of strong acidic ion exchange resin and 0.068 g of myricetin for reflux reaction for 4 h. After the reaction was completed, 0.857 g of the target product in the form of white crystals was obtained by silica gel column chromatography and recrystallization. Wherein, the operation process of column chromatography separation and recrystallization is the same as that of Example 1.
Embodiment 3
[0034] A preparation method of sugar derivative tobacco flavoring and moisturizing agent Mal-Pro, which comprises the following steps:
[0035] Add 1 gram of maltose, 1.5 mL of propylene glycol and 1.0 mL of anhydrous methanol into a three-necked flask with a thermometer and a condenser tube, reflux at 89°C for 40 minutes, then add 0.25 grams of proline and reflux for another 20 minutes, and finally add 0.05 grams of strong Acidic ion exchange resin and 0.088 g of myricetin were refluxed for 8 h to react. After the reaction was completed, 0.632 g of the target product in the form of white crystals was obtained by silica gel column chromatography and recrystallization. Wherein, the operation process of column chromatography separation and recrystallization is the same as that of Example 1.
[0036] (1) Structural characterization of the target product
[0037] Through infrared spectroscopy (IR), high-resolution mass spectrometry (HR-MS), carbon nuclear magnetic resonance sp...
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