Components and preparation of vitamin C effervescent tablets

Abstract

The invention discloses components and preparation of vitamin C effervescent tablets. Vitamin C, citric acid, sodium carbonate/sodium bicarbonate (1:9), lactose/mannitol, orange-flavored essence and 2-5 percent of polyethylene glycol 4000 are taken as raw materials. The preparation method comprises the following steps: weighing the ground vitamin C and citric acid, uniformly mixing, adding a certain amount of absolute ethyl alcohol containing 5 percent of PVP so as to prepare a soft material, granulating by using a 20-mesh nylon screen, drying at the temperature of 45 DEG C, (the temperature is not too high and deterioration of the vitamin C is avoided), and pelleting by using a 18-mesh screen; weighing the ground arbonate/sodium bicarbonate, lactose/mannitol and polyethylene glycol according to the formula, uniformly mixing, adding absolute ethyl alcohol containing 1 percent of PVP so as to prepare a soft material, (the soft material can be agglomerated if held slightly and can be scattered if pressed slightly), granulating by using a 20-mesh nylon screen, drying at the temperature of 60 DEG C, and pelleting by using a 30-mesh screen; weighing and mixing the two kinds of granules according to a ratio, adding 0.2 percent of orange-flavored essence and 2.8 percent of PEG4000, uniformly mixing, checking the granules, and tabletting. The vitamin C effervescent tablets disclosed by the invention are good in taste and low in local concentration in the stomach, are easily and completely absorbed by the human body and do not have irritation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to components and preparation of a vitamin C effervescent tablet. Background technique [0002] As one of the essential vitamins for the human body, vitamin C can participate in the metabolism of amino acids, the synthesis of neurotransmitters, the synthesis of collagen and tissue interstitium, reduce the permeability of capillaries, promote iron absorption, and improve cholesterol metabolism , antihistamine, enhance immunity, etc. Taking it can increase the body's resistance and prevent the invasion of cold viruses. [0003] The structure of vitamin C is similar to monosaccharides, and it is generally believed that it is an important cofactor of proline hydroxylase and lysine hydroxylase necessary for collagen biosynthesis, and can enhance the activity of various hydroxylases and oxidases. The reversibility of redox ability, which is very active in microsomal electron transpor...

AI Technical Summary

Problems solved by technology

However, the effervescent materials of such preparations are easily restricted by the external environment.

Large doses of vitamin C help to enhance the body's resistance and prevent diseases, but large doses of vitamin C tablets are difficult to swallow directly, and when they disintegrate in the stomach, the local concentration is large, which is easy to damage the gastric mucosa