Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Components and preparation of vitamin C effervescent tablets

A technology for vitamins and effervescent tablets, applied in the field of medicine, can solve the problems of high local concentration, effervescent materials are easily restricted by the external environment, damage gastric mucosa, etc., and achieve the effects of low local concentration, smooth appearance, and high effervescent strength.

Inactive Publication Date: 2015-03-25
WEIHAI NOVODA PHARMA GRP
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effervescent materials of such preparations are easily restricted by the external environment.
Large doses of vitamin C help to enhance the body's resistance and prevent diseases, but large doses of vitamin C tablets are difficult to swallow directly, and when they disintegrate in the stomach, the local concentration is large, which is easy to damage the gastric mucosa

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A vitamin C effervescent tablet, characterized in that its component content is: vitamin C 2%-3%, citric acid 30%-35%, sodium carbonate / sodium bicarbonate (1:9) 20%-25%, Lactose / mannitol (10:1) 40%-45%, orange flavor 0.2%-0.5%, polyethylene glycol 4000 2%-5%.

Embodiment 2

[0015] A vitamin C, the preferred content of each component is: vitamin C 2%, citric acid 33.3%, sodium carbonate / sodium bicarbonate (1:9) 20%, lactose / mannitol (10:1) 41.7%, orange Flavor essence 0.2%, polyethylene glycol 4000 2.8%.

[0016] 1. Weigh the crushed vitamin C and citric acid, mix them evenly, add an appropriate amount of soft material containing 5% PVP absolute ethanol, granulate with a 20-mesh nylon screen, and dry at 45°C (the temperature should not be too high to prevent the deterioration of vitamin C ), 18 mesh whole grains.

[0017] 2. Weigh the crushed sodium carbonate / sodium bicarbonate, lactose / mannitol, and polyethylene glycol according to the prescription, mix well and add soft material containing 1% PVP anhydrous ethanol (soft material principle: hold lightly to form a ball , lightly press to disperse), granulate with 20-mesh nylon screen, dry at 60°C, and granulate with 30-mesh.

[0018] 3. Weigh and combine the above two kinds of granules in propor...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
boiling pointaaaaaaaaaa
Login to View More

Abstract

The invention discloses components and preparation of vitamin C effervescent tablets. Vitamin C, citric acid, sodium carbonate / sodium bicarbonate (1:9), lactose / mannitol, orange-flavored essence and 2-5 percent of polyethylene glycol 4000 are taken as raw materials. The preparation method comprises the following steps: weighing the ground vitamin C and citric acid, uniformly mixing, adding a certain amount of absolute ethyl alcohol containing 5 percent of PVP so as to prepare a soft material, granulating by using a 20-mesh nylon screen, drying at the temperature of 45 DEG C, (the temperature is not too high and deterioration of the vitamin C is avoided), and pelleting by using a 18-mesh screen; weighing the ground arbonate / sodium bicarbonate, lactose / mannitol and polyethylene glycol according to the formula, uniformly mixing, adding absolute ethyl alcohol containing 1 percent of PVP so as to prepare a soft material, (the soft material can be agglomerated if held slightly and can be scattered if pressed slightly), granulating by using a 20-mesh nylon screen, drying at the temperature of 60 DEG C, and pelleting by using a 30-mesh screen; weighing and mixing the two kinds of granules according to a ratio, adding 0.2 percent of orange-flavored essence and 2.8 percent of PEG4000, uniformly mixing, checking the granules, and tabletting. The vitamin C effervescent tablets disclosed by the invention are good in taste and low in local concentration in the stomach, are easily and completely absorbed by the human body and do not have irritation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to components and preparation of a vitamin C effervescent tablet. Background technique [0002] As one of the essential vitamins for the human body, vitamin C can participate in the metabolism of amino acids, the synthesis of neurotransmitters, the synthesis of collagen and tissue interstitium, reduce the permeability of capillaries, promote iron absorption, and improve cholesterol metabolism , antihistamine, enhance immunity, etc. Taking it can increase the body's resistance and prevent the invasion of cold viruses. [0003] The structure of vitamin C is similar to monosaccharides, and it is generally believed that it is an important cofactor of proline hydroxylase and lysine hydroxylase necessary for collagen biosynthesis, and can enhance the activity of various hydroxylases and oxidases. The reversibility of redox ability, which is very active in microsomal electron transpor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/375A61P3/02A61P37/04A61P3/06A61P11/00A61P37/08
Inventor 王河东张庆卫由红运
Owner WEIHAI NOVODA PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products