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Composite artificial bone material and preparation method thereof

A technology of artificial bone and calcium sulfate, applied in the medical field, can solve problems such as transportation and storage difficulties, achieve transformation and large-scale production, excellent biological activity, and promote cell growth

Active Publication Date: 2015-03-25
FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this technique requires specialized cell culture sites and facilities, and there are many difficulties in transportation and storage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Use deionized water to configure sodium sulfate solution and calcium nitrate solution with a molar ratio of 1:2, and pass the above two solutions slowly through 100-nanometer bacterial filtration at a speed of 0.2ml / s under the environment of a 10,000-class laminar flow clean room membrane to remove insoluble precipitates, suspended solids, bacteria, fungi, and bacterial debris, and then add 15% lithium chloride solution filtered through a 100-nanometer bacterial filtration membrane to the Lithium solution equal volume calcium nitrate solution container, and then sodium sulfate solution was slowly added to the container at a rate of 0.2ml / s, and reacted for 4 hours under shaking conditions. Take out the impurity-containing calcium sulfate precipitate generated in the container under the local 100-level ultra-clean environment in the laminar flow clean room, add water for injection and centrifuge repeatedly, discard the supernatant for 5 times, and use the ratio of the...

Embodiment 2

[0022] 1) Use deionized water to configure potassium sulfate solution and calcium nitrate solution with a molar ratio of 1:2, and pass the above two solutions slowly through a 100-nanometer bacterial filter at a speed of 0.2ml / s under the environment of a 10,000-class laminar flow clean room membrane to remove insoluble precipitates, suspended solids, bacteria, fungi, and bacterial debris, and then add 15% lithium chloride solution filtered through a 100-nanometer bacterial filtration membrane to the Lithium solution equal volume calcium nitrate solution container, and then potassium sulfate solution was slowly added to the container at a rate of 0.1ml / s, and reacted under shaking conditions for 4 hours. Take out the impurity-containing calcium sulfate precipitate generated in the container under the local 100-level ultra-clean environment in the laminar flow clean room, add water for injection and centrifuge repeatedly, and discard the supernatant for 6 times. The ratio of the...

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Abstract

The invention discloses a composite artificial bone material, comprising the following raw materials in parts by weight: 20-99 parts of high-purity spherical nanocrystalline calcium sulphate powder with the purity being greater than 99.9%, and 1-80 parts of lyophilized cell powder. A preparation method of the composite artificial bone material comprises the following steps: preparing high-purity spherical nanocrystalline calcium sulphate powder; drying stem cells or osteoblasts of mesenchymal origin at the temperature of 0 to 80 DEG C in vacuum, preserving the activity, thereby obtaining lyophilized cell powder with abundant active substances; and evenly mixing the lyophilized cell powder with calcium sulfate powder, and pressing into tablets with different sizes. According to the composite artificial bone material disclosed by the invention, safe application of a human body can be ensured by using the high-purity spherical nanocrystalline calcium sulphate powder; the activity and the degradability of bone materials can be significantly improved by using the lyophilized cell powder with abundant active substances; compared with composite living cell components, irradiation sterilization can be carried out on the basis that a lot of active osteogenesis factors and functions are reserved; and the composite artificial bone material is convenient to store and transport at room temperature for a long period of time, and can be treated and processed according to an implant material way.

Description

technical field [0001] The invention relates to the medical field, in particular to a composite artificial bone material and a preparation method thereof. Background technique [0002] At present, various clinical bone repair materials are mainly titanium metal, alumina ceramics, bioglass, tricalcium phosphate (TCP), polymethyl methacrylate (PMMA), bone cement, and various hydroxyapatite (HAP)-based materials. basic biological material. The above-mentioned materials have limited their applications due to defects such as biocompatibility and osteoinductivity. [0003] In the 1990s, Wright Medical Technology Co., Ltd. of the United States developed and produced a new generation of bone graft substitute product OsteoSet using calcium sulfate as a matrix. It is calcium sulfate hemihydrate (CaSO4·1 / 2H2O) made by a special method. With good biocompatibility and osteoinductive effect, it is a bone graft substitute approved by the US FDA (US Food and Drug Administration) and appro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38A61L27/02A61L27/54
Inventor 赵彦涛白玉龙韩丽伟李忠海朱加亮衷鸿宾侯树勋别晓梅胡先同
Owner FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA
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