Antibacterial silicone rubber composite

A composite material and silicone rubber technology, which is applied in the field of medical silicone rubber composite materials, can solve the problems of short service life and easy infection of bacteria, and achieve the effect of uniform distribution, smooth appearance and good biological safety

Inactive Publication Date: 2015-03-25
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the problems and defects in the prior art, the purpose of the present invention is to provide a silicone rubber composite material with long-term antibacterial effect, which overcomes the problems of traditional silicone rubber materials such as easy infection of bacteria and short service life, and can be used in oral and maxillofacial Widely used in prosthetic restorations

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0026] Example 1: Preparation and Performance Evaluation of Cefuroxime Sodium Silicone Rubber Composite Material

[0027] In this example, cefuroxime sodium was selected as the antibacterial drug, and cefuroxime sodium silicone rubber composite material was prepared with silicone rubber matrix, and then the mechanical properties, antibacterial activity, and biological safety of the silicone rubber composite material were initially evaluated. This provides a basis for the further application of cefuroxime sodium silicone rubber composites.

[0028] Choice of drug: Staphylococcus aureus is one of the common bacteria that cause infection after oral and maxillofacial revision surgery. Cefuroxime sodium is a second-generation cephalosporin antibiotic, which can inhibit all penicillin-sensitive and drug-resistant Staphylococcus aureus at a concentration of 1-2 mg / L. Therefore, in this example, cefuroxime sodium was selected as a model drug to prepare a cefuroxime sodium silicone ru...

Embodiment 2

[0082] Example 2: Preparation and performance evaluation of cefuroxime sodium polylactic acid-glycolic acid nano-silicone rubber composite material

[0083] In this example, cefuroxime sodium was selected as the antibacterial drug, and cefuroxime sodium polylactic acid-glycolic acid nano-silicone rubber composite material was prepared, and then the mechanical properties, antibacterial activity, and biological safety of the silicone rubber composite material were initially evaluated. , to provide a basis for the further application of cefuroxime sodium silicone rubber composites.

[0084] Reagents and instruments: cefuroxime sodium (ACS Dobfar S.P.A, purity 96%, Italy); polylactic acid-glycolic acid copolymer (PLGA, polylactic acid / glycolic acid=50 / 50, viscosity 0.43dl / gShandong Medical Device Research Institute, Shandong); Polyvinyl alcohol (PVA, alcoholysis degree = 87.0-89.0%, Aladdin, Shanghai); Silicone rubber (MDX4-4210, Dowcorning, USA); Staphylococcus aureus (ATCC29213,...

Embodiment 3

[0100] Example 3: Preparation and Performance Evaluation of Benzoyl Metronidazole Silicone Rubber Composite Material

[0101] In this example, benzoyl metronidazole was selected as an antibacterial drug, and benzoyl metronidazole silicone rubber composite material was prepared with a silicone rubber matrix, and then the mechanical properties, antibacterial activity, and biological safety of the silicone rubber composite material were initially evaluated. , to provide a basis for the further application of benzoyl metronidazole silicone rubber composites.

[0102] Choice of drug: Benzoyl metronidazole is a new generation of non-bitter nitroimidazole antibacterial drug obtained after benzoic acid modification of metronidazole. Therefore, in this example, benzoyl metronidazole was selected as a model drug to prepare a benzoyl metronidazole silicone rubber composite material. In this example, Fusobacterium nucleatum was selected as the target strain for related experimental resea...

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Abstract

The invention relates to an antibacterial silicone rubber composite. The antibacterial silicone rubber composite provided by the invention includes a silicone rubber matrix and an antibacterial medicament mixed with the silicone rubber matrix. The antibacterial silicone rubber composite provided by the invention maintains good tensile strength, tensile elongation, tear strength and elongation at break of traditional materials; the medicament can slowly release from the composite and achieve effective antibacterial concentration; and the composite has better biocompatibility. The invention provides an optimal process for the preparation of the antibacterial silicone rubber composite.

Description

technical field [0001] The invention relates to a medical silicone rubber composite material, in particular to an antibacterial silicone rubber composite material. Background technique [0002] Silicone rubber material is the most commonly used prosthetic repair material after oral and maxillofacial surgery, and the performance of silicone rubber material is an important factor affecting the final effect of the restoration. At present, there are still many deficiencies in the performance of silicone rubber materials. Long-term use of traditional silicone rubber materials can easily lead to the growth of pathogenic microorganisms and cause infection. For example, Staphylococcus aureus is one of the common bacteria causing infection after oral and maxillofacial restorations. Staphylococcus aureus on silicone rubber materials can be killed by using medical disinfectants, but because silicone rubber has an organic polymer structure, frequent soaking of disinfectants will accel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/18
Inventor 刘琦荆冬冬邵龙泉李国峰王琳琳艾俊冯晓黎
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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