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Riboflavin gastric-floating tablet and preparation method thereof

A gastric floating tablet and riboflavin technology, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. The effect of improving drug bioavailability

Active Publication Date: 2015-04-01
CHANGSHA BAISHUN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Two properties of vitamin B2 are the main cause of its loss: (1) can be destroyed by light; (2) can be destroyed by heating in alkaline solution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: (prepare 1000 tablets)

[0027] Riboflavin 5g

[0028] Hydroxypropyl Methyl Cellulose 68g

[0029] Ethyl cellulose 30g

[0030] Cetyl Alcohol 42g

[0031] Lactose 34g

[0032] Sodium bicarbonate 11g

[0033] Light Medicinal Calcium Carbonate 4g

[0034] Magnesium Stearate 6g

[0035] Preparation:

[0036] 1) Pass riboflavin, hydroxypropylmethylcellulose, ethylcellulose, sodium bicarbonate, lactose, and light medicinal calcium carbonate through 80-mesh sieves;

[0037] 2) Weigh the prescription amount of each auxiliary material in a mortar and mix them evenly, add them to the molten cetyl alcohol at a melting temperature of 50°C, mix well, and pass through a 20-mesh sieve after cooling;

[0038] 3) Use step 1) and step 2) to make soft materials with 70% ethanol, and pass through a 24-mesh sieve to granulate;

[0039] 4) Dry at 45°C, granulate, add magnesium stearate and mix well, then compress into tablets, the hardness of gastric floating tablets ...

Embodiment 2

[0041] Prescription: (prepare 1000 tablets)

[0042] Riboflavin 5g

[0043] Hydroxypropyl Methyl Cellulose 60g

[0044] Ethylcellulose 34g

[0045] Cetyl Alcohol 46g

[0046] Lactose 34g

[0047] Sodium bicarbonate 11g

[0048] Light Medicinal Calcium Carbonate 4g

[0049] Magnesium Stearate 6g

[0050] Preparation:

[0051] 1) Pass riboflavin, hydroxypropylmethylcellulose, ethylcellulose, sodium bicarbonate, lactose, and light medicinal calcium carbonate through 80-mesh sieves;

[0052] 2) Weigh and mix the excipients in the prescription amount in a mortar, add to the molten cetyl alcohol, control the melting temperature at 55°C, mix well, and pass through a 20-mesh sieve after cooling;

[0053] 3) Use step 1) and step 2) to make soft materials with 60% ethanol, and pass through a 18-mesh sieve to granulate;

[0054] 4) Dry at 50°C, granulate, add magnesium stearate and mix well, then compress into tablets, the hardness of gastric floating tablets is 3-4kg / cm 2 . ...

Embodiment 3

[0056] Prescription: (prepare 1000 tablets)

[0057] Riboflavin 5g

[0058] Hydroxypropyl Methyl Cellulose 76g

[0059] Ethylcellulose 26g

[0060] Cetyl Alcohol 38g

[0061] Lactose 34g

[0062] Sodium bicarbonate 11g

[0063] Light Medicinal Calcium Carbonate 4g

[0064] Magnesium Stearate 6g

[0065] Preparation:

[0066] 1) Pass riboflavin, hydroxypropylmethylcellulose, ethylcellulose, sodium bicarbonate, lactose, and light medicinal calcium carbonate through 80-mesh sieves;

[0067] 2) Weigh the prescription amount of each auxiliary material, mix it in a mortar, add it to the molten cetyl alcohol, control the melting temperature at 60°C, mix well, and pass through a 20-mesh sieve after cooling;

[0068] 3) Use step 1) and step 2) to make soft materials with 50% ethanol, and pass through a 24-mesh sieve to granulate;

[0069] 4) Dry at 55°C, granulate, add magnesium stearate and mix well, then compress into tablets, the hardness of gastric floating tablets is 3-4kg / ...

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Abstract

The invention provides a riboflavin gastric-floating tablet and a preparation method thereof. The riboflavin gastric-floating tablet prepared by the method comprises the following raw materials in percentage by weight: 1%-5% of riboflavin, 10%-50% of hydroxypropyl methyl cellulose, 5%-25% of ethylcellulose, 2%-40% of hexadecanol, 5%-40% of lactose, 1%-10% of sodium bicarbonate, 1%-10% of light pharmaceutical calcium carbonate and 1%-10% of magnesium stearate. The riboflavin gastric-floating tablet is low in toxic and side effects of medication, has the functions of prolonging the action time of medicines, and maintaining stable plasma drug concentration; and the bioavailability of the medicine is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a riboflavin gastric floating tablet and a preparation method thereof. Background technique [0002] Vitamin B2 (chemical formula: C17H20N4O6, formula weight 376.37), also known as riboflavin, is slightly soluble in water and stable when heated in neutral or acidic solutions. It is a part of the prosthetic group of yellow enzymes in the body (yellow enzyme plays the role of hydrogen transfer in biological redox). When it is lacking, it will affect the biological oxidation of the body and cause metabolic disorders. The lesions are often manifested as inflammation of the mouth, eyes and external genitalia, such as angular cheilitis, cheilitis, glossitis, conjunctivitis and scrotal inflammation, so this product can be used for the prevention and treatment of the above diseases. The storage of vitamin B2 in the body is very limited, so it must be provided by di...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/525A61P3/02A61K47/38
Inventor 不公告发明人
Owner CHANGSHA BAISHUN BIOTECH
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