Compound used as dual inhibitor for RAAS (rennin angiotensin aldosterone system)

Abstract

The invention discloses a compound used as a dual inhibitor for RAAS (rennin angiotensin aldosterone system) and particularly relates to a compound shown in formula (I), a stereisomer thereof or a pharmaceutically acceptable salt thereof. The compound can be used for treating and blocking RAS-associated diseases such as hypertension and heart disease, can be used for preventing or treating hypertension, congestive heart failure, pulmonary hypertension, renal insufficiency, renal ischemia, kidney failure, renal fibrosis, cardiac insufficiency, cardiac hypertrophy, cardiac fibrosis, myocardial ischemia, cardiomyopathy, glomerulonephritis, renal colic, complications such as nephropathy caused by diabetes, vasculopathy, vasculopathy, glaucoma, intraocular pressure elevation, atherosis, restenosis after revascularization, complications after blood vessel or cardiac operation, erectile dysfunction, hyperaldosteronism, lung fibrosis, scleroderma, anxiety, cognitive disorder, complications caused by immunosuppressor treatment as well as other known diseases associated with the rennin angiotensin aldosterone system.

Description

technical field

[0001] The invention relates to a compound as a dual inhibitor of renin-angiotensin-aldosterone (RAAS) system, which can be used for treating diseases related to the RAS system, including hypertension, heart disease and the like. Background technique

[0002] The renin-angiotensin-aldosterone system (RAAS) is a complex and highly efficient system necessary for the regulation of blood flow, electrolyte balance, and arterial blood pressure. The two main parts of this system are renin and angiotensin transferase. Renin is an aspartyl protease that converts angiotensinogen produced in the liver into angiotensin I, and angiotensin I generates blood vessels under the action of angiotensin I converting enzyme (ACE) Tensin II is finally converted into angiotensin III that can promote aldosterone secretion and inactivated. Angiotensin Ⅱ is a powerful peptide vasoconstrictor that can promote the release of norepinephrine from nerve endings, and can also activate prot...

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