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Compound microorganism preparation for improving male sperm quality and preparation method thereof

A technology for male sperm quality and compound microorganisms, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, sexual diseases, etc. , to achieve easier absorption and utilization, improve the quality of men's sperm, the effect is remarkable

Active Publication Date: 2015-04-22
江瀚生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wuzi Yanzong Pill is the basic prescription of traditional Chinese medicine for treating infertility. Its treatment principle is to warm the kidney and fill the marrow. It has a certain effect on some patients, but it needs to be taken for a long time
[0004] Existing invention patents are generally developed from Chinese herbal medicines or their extracts. Chinese herbal medicines need to be processed or processed to extract active ingredients before taking them to have a significant effect; if they are taken directly without processing, the active ingredients are not easy to use due to absorption barriers ,no significant effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment one (solid dosage form)

[0048] The first step, production of seeds

[0049] Transfer Saccharomyces cerevisiae (ACCC20065) purchased from the China Agricultural Microorganism Culture Collection and Management Center into an Erlenmeyer flask of potato liquid medium, and culture it with shaking at 28°C and 180-220rpm for 48 hours. After the medium is turbid Take out; Lactobacillus acidophilus (ACCC10637), Lactobacillus plantarum (Lactobacillus plantarum, ACCC11118), Bifidobacterium (Bifidobacterium, ACCC11054), were transferred into conical flasks of MRS liquid medium, and cultured at 37°C After 48 hours, take out the culture medium after it becomes turbid, and then store it in a 4°C refrigerator for later use;

[0050] The second step, the compound culture of bacteria

[0051] (1) The strains cultivated in step 1 are weighed according to the following weight percentages: 15% of Saccharomyces cerevisiae, 30% of Lactobacillus acidophilus, 30% of Lactobacillus p...

Embodiment 2

[0062] Embodiment two (oral liquid type)

[0063] The first step: with embodiment one;

[0064] The second step: the compound culture of bacteria

[0065] (1) The strains cultivated in step 1 are weighed according to the following weight percentages: 10% of Saccharomyces cerevisiae, 30% of Lactobacillus acidophilus, 30% of Lactobacillus plantarum, and 30% of Bifidobacterium;

[0066] (2) Compound culture of strains: Put the strains weighed above into the raw materials with the ratio of 1:100: 3% brown sugar, 97% pure water, put them into a fermenter and stir them evenly, and culture them in a closed manner at 32°C. Cultivate for 12 days after the pH is less than 3.60;

[0067] The third step, compound fermentation of raw materials

[0068] (1) Raw material pulverization: Pueraria lobata, seabuckthorn and grape seed that are evenly screened are pulverized into 40 meshes by pulverizer respectively;

[0069] (2) Composite fermentation: put the above compound cultured strains ...

Embodiment 3

[0077] Animal grouping: Select healthy and clean male Kunming mice, weighing 18-22 g, and after 2 days of routine adaptive feeding, they are randomly divided into 2 groups (blank group and drug administration group).

[0078] Determination of the dosage: according to the recommended dosage for humans (1.5g solid dosage form / d or 50ml liquid dosage form / d), the mouse equivalent dose is used as the intragastric administration dose, that is, 0.30g solid dosage form / kg BW / d or 10ml liquid Dosage form / kg BW / d, oral administration, intragastric volume 20mL / kg·BW, blank group intragastric administration of distilled water.

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Abstract

The invention discloses a natural biological preparation for improving male sperm quality through compound microorganism tradtional Chinese medicine production. The microorganism in the microorganism preparation comprises the following components in percentage by weight: 10-20% of brewer's yeast, 20-30% of lactobacillus acidophilus, 20-30% of lactobacillus plantarum and 20-30% of bifidobacterium. The natural biological preparation has the advantage of improving the male sperm quality; the effective constituents of the traditional Chinese medicines are converted through a microorganism compound fermentation technology, so that the natural biological preparation has the characteristics of being easier to absorb and utilize and remarkable in effect; and the natural biological preparation has the effects of resisting oxidation, scavenging free radicals and improving male sperm quality.

Description

technical field [0001] The invention relates to a health food, in particular to a compound microbial preparation for improving the quality of male sperm. Background technique [0002] Statistics from WHO show that the worldwide incidence of infertility accounts for about 15% of couples of childbearing age, of which male infertility accounts for about 50%, and male infertility caused by low sperm motility accounts for about 30%. Epidemiological survey data show that the number of sperm in male semen and the movement parameters of sperm have shown a clear downward trend in the past half century, and the normal standard of human sperm count has been greater than 60 million per sperm count since the 1960s and 1970s Milliliters have dropped to the current 20 million / ml, and abnormal sperm such as lack of motivation and abnormal morphology have increased. The reasons for the decline of sperm quality are very complicated, some are congenital or acquired diseases, and some are caus...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P15/08A61P39/06A61K35/745A61K35/747
CPCA61K9/0053A61K9/08A61K9/1623A61K35/745A61K35/747A61K36/185A61K36/488A61K36/87A61K47/26A61K2236/19A61K2300/00
Inventor 江瀚陈琦冈
Owner 江瀚生物科技(上海)有限公司
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