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Traditional Chinese medicine composition capsule for treating climacteric syndrome and preparation method of traditional Chinese medicine composition capsule

A syndrome and composition technology, which is applied in the field of preparation of medicines and therapeutic medicines for gynecological diseases, can solve the problems of unpleasant smell, large dosage of granules, poor patient compliance, etc., and achieves good drug efficacy and properties, good treatment effect, good stability effect

Inactive Publication Date: 2015-04-22
YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing Chinese medicines that treat menopausal syndrome with Chinese medicines as raw materials are mostly granules. Because Chinese medicines have many volatile oils, the smell is irritating and unpleasant, and Chinese medicines themselves have bitter tastes. The compliance is extremely poor; at the same time, the dosage of granules is large, the stability of volatile oil is extremely poor, and the packaging and sealing performance of granules is poor, resulting in poor stability of the drug, easy to absorb moisture, etc.

Method used

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  • Traditional Chinese medicine composition capsule for treating climacteric syndrome and preparation method of traditional Chinese medicine composition capsule
  • Traditional Chinese medicine composition capsule for treating climacteric syndrome and preparation method of traditional Chinese medicine composition capsule
  • Traditional Chinese medicine composition capsule for treating climacteric syndrome and preparation method of traditional Chinese medicine composition capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Radix Paeoniae Alba 345g; Bupleurum 228g; Rhizoma Cyperi 345g; Woody Fragrance 228g;

[0090] Chuanqiong 228g; Citrus aurantium 228g; Ginger pinellia 345g;

[0091] Fried toosendan 345g; cardamom 228g; licorice 228g.

[0092] β-cyclodextrin 6 times the weight of volatile oil;

[0093] Calcium hydrogen phosphate 40g;

[0094] Micronized silica gel 4g.

[0095] A. Extraction of volatile oil

[0096] Take Cyperus Cyperi, Bupleurum, Chuanqiong, Citrus Fructus, Cardamom, and Woody Fragrance in the prescribed amount, add water 5 times the weight of the above-mentioned medicines, heat and reflux for 5 hours to extract the volatile oil, and filter the medicine liquid and medicine residue for later use; Volatile oil, primary filtrate and medicinal residues;

[0097] B, preparation of extract powder

[0098] Add water to decoct the medicinal dregs in step A, white peony root, fried toosendan, ginger pinellia, and licorice three times, adding 10 times the weight of water eac...

Embodiment 2

[0104] Radix Paeoniae Alba 320g; Bupleurum 200g; Rhizoma Cyperi 320g; Woody Fragrance 200g;

[0105] Chuanqiong 200g; Citrus aurantium 200g; Ginger pinellia 345g;

[0106] Stir-fried toosendan 320g; cardamom 200g; licorice 200g.

[0107] β-cyclodextrin 6 times the weight of volatile oil;

[0108] Calcium hydrogen phosphate 40g;

[0109] Micronized silica gel 4g

[0110] A. Extraction of volatile oil

[0111] Take Cyperus Cyperi, Bupleurum, Chuanqiong, Citrus Fructus, Cardamom, and Woody Fragrance in the prescribed amount, add water 5 times the weight of the above-mentioned medicines, heat and reflux for 5 hours to extract the volatile oil, and filter the medicine liquid and medicine residue for later use; Volatile oil, primary filtrate and medicinal residues;

[0112] B, preparation of extract powder

[0113] Add water to decoct the medicinal dregs in step A, white peony root, fried toosendan, ginger pinellia, and licorice three times, adding 10 times the weight of water e...

Embodiment 3

[0119] Pharmacological efficacy experiments:

[0120] 50 of healthy SPF grade SD old female mice (12~15 months old) are randomly divided into model control group, granule group (11g crude drug / kg), 3 dose groups of capsules of the present invention (11, 5.5, 2.75g) by body weight Original drug / kg), a total of 5 groups, 10 rats in each group. Another 10 female SD rats aged 2-3 months were used as the young control group. The drug solution with equal volume and different concentration was administered by intragastric administration, the administration volume was 1ml / 100g, and the model control group and the youth control group were intragastrically administered with equal volume of distilled water, administered once a day for 8 consecutive weeks. Detection indicators: (1) General behavioral observation: record whether the rats have piloerection, panic, irritation, difficult to grasp, etc. during the experiment; (2) serum follicle-stimulating hormone (FSH), luteinizing hormone (...

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Abstract

The invention discloses a traditional Chinese medicine composition capsule for treating a climacteric syndrome and a preparation method of the traditional Chinese medicine composition capsule. The traditional Chinese medicine composition capsule is prepared by the following steps: heating and refluxing white peony root, bupleurum, rhizoma cyperi, costusroot, sichuan lovage rhizome, fructus aurantii, pinellia ternata prepared with ginger, fried melia toosendan, fructus amomi rotundus and liquorice; collecting volatile oil, carrying out water extraction and alcohol precipitation, merging extract powder with a cyclodextrin inclusion, and adding calcium hydrogen phosphate and superfine silica powder, so as to prepare the capsule. The traditional Chinese medicine disclosed by the invention has a good medicine effect on treatment of the climacteric syndrome, and is long in storage time, and high in stability; the bitter taste of the medicine can be concealed; and discomfort of patients caused by medication is reduced.

Description

technical field [0001] The invention relates to the technical field of preparation of medicines and medicines for gynecological diseases, in particular to a traditional Chinese medicine composition capsule for treating climacteric syndrome and a preparation method thereof. Background technique [0002] Premenstrual syndrome and menopausal syndrome are common and frequently occurring diseases in gynecology today. With the increase of social pressure and work pressure, the incidence rate has been rising day by day in recent years, and it has also attracted people's attention. The incidence of premenstrual syndrome accounts for about 40% of women, and climacteric syndrome accounts for about 30% of postmenopausal women. It is characterized by a series of physical and mental symptoms, which affects women's daily life and work. [0003] In terms of competitive advantage with similar products, for premenstrual syndrome and menopausal syndrome, Western medicine mainly treats sympto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/48A61K47/48A61P15/12A61K47/69
CPCA61K36/8905A61K9/4866A61K36/233A61K36/236A61K36/285A61K36/484A61K36/58A61K36/65A61K36/71A61K36/752A61K36/8888A61K36/9064A61K2236/331A61K2236/39A61K2236/51
Inventor 李元波吴品江周唯兰王颖颜欢周芯宇何晓
Owner YANGTZE RIVER PHARM GRP SICHUAN HAIRONG PHARM CO LTD
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