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Preparation method of 1, 3-dioleoyl-2-palmitoyl triglyceride

A technology of palmitic acid triglyceride and palmitic glyceride, which is applied in the field of preparation of organic compounds, can solve problems such as difficulty in maintaining stable product quality, high price, and unstable source of raw materials, and achieve superior quality, controllable quality, and raw material The effect of source stability

Inactive Publication Date: 2015-04-29
CHANGZHOU JUNSHI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The problem existing in the process of preparing 1,3-dioleic acid-2-palmitic acid triglyceride in the prior art is: the process mostly adopts industrial-grade palmitic acid to synthesize palmitic acid triglyceride, and then combines it with high-purity oleic acid Catalyzed synthesis of fats or oils with high oleic acid content
The source of raw materials for this process is unstable, the product quality is difficult to maintain, and the price is high (the market price of palmitic acid is about 8000-9000 yuan / ton, and the high-purity oleic acid is about 12000-15000 yuan / ton)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment has the following steps:

[0028] ① Use commercially available crude palm oil as raw material, select Candida sp.99-125 lipase as the hydrolysis reaction catalyst, add 1kg of crude palm oil, 20kg of water and 100g of lipase to the reaction. After reacting at 45°C for 48 hours, the acid value of crude palm oil increased from the initial 5.6mgKOH / g to 189mgKOH / g. Filter and separate lipase.

[0029] ②Using the method of crystallization to separate the separated oleic acid and palmitic acid obtained in step ①, after separation, 220g of crude oleic acid and 710g of crude palmitic acid were obtained.

[0030] ③Use sulfuric acid as a catalyst for the synthesis of tripalmitin, add 700g of crude palmitic acid obtained in step ②, add 90g of glycerin, 15g of sulfuric acid, the reaction temperature is 90°C, and the reaction time is 3 hours. Na after reaction 2 CO 3 The solution was neutralized with sulfuric acid, and 750 g of tripalmitin with a purity of 92% wa...

Embodiment 2

[0034] This embodiment has the following steps:

[0035] ① Use commercially available 44% palm oil as raw material, select sulfuric acid as the hydrolysis reaction catalyst, add 1kg palm oil, 10kg water and 20g sulfuric acid to the reaction. After pressure reaction at 120°C for 12 hours, the acid value of palm oil increased from the initial 3.2mgKOH / g to 176mgKOH / g. Neutralizes sulfuric acid.

[0036] ②Using crystallization to separate the oleic acid and palmitic acid obtained in the separation step ①, after separation, 250g of crude oleic acid and 690g of crude palmitic acid were obtained.

[0037] ③Use sulfuric acid as a tripalmitin synthesis catalyst, add 650g of the crude palmitic acid obtained in step ②, add 80g of glycerin, 15g of sulfuric acid, the reaction temperature is 90°C, and the reaction time is 3 hours. Na after reaction 2 CO 3 The solution was neutralized with sulfuric acid, and 700 g of tripalmitin with a purity of 90% was obtained after phase separation. ...

Embodiment 3

[0041] This embodiment has the following steps:

[0042] ①Using edible palm oil imported from Malaysia as raw material, using Candida sp.99-125 lipase (Candida lipase, produced by Beijing Kaitai New Century Co., Ltd.) as the hydrolysis catalyst, adding 10kg palm oil, 100kg water and 1kg Lipase. After reacting at 50°C for 48 hours, the acid value of palm oil increased from the initial 0.6mgKOH / g to 179mgKOH / g.

[0043] ② The oleic acid and palmitic acid obtained in step ① were separated by crystallization, and 2.8 kg of crude oleic acid and 7.0 kg of crude palmitic acid were obtained after separation.

[0044] 3. Sulfuric acid was used as a tripalmitin synthesis catalyst, 7 kg of crude palmitic acid obtained in step 2 was added, 0.9 kg of glycerin was added, 150 g of sulfuric acid was added, the reaction temperature was 110° C., and the reaction time was 3 hours. Na after reaction 2 CO 3 The solution neutralized sulfuric acid, and obtained 7.4 kg of tripalmitin with a purit...

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Abstract

The invention relates to a method for preparing 1, 3-dioleoyl 2-palmitoyl triglyceride by taking palm oil as a raw material. The preparation method comprises the following steps: (1), palm oil is taken as the basic raw material and is hydrolyzed under catalysis of a catalyst so as to prepare an oleic acid and palmitic acid mixture; (2), the oleic acid and palmitic acid mixture is separated; (3), separated palmitic acid is taken as a raw material to synthesize tripalmitin under the action of a catalyst; and (4), lipase catalyzed oleic acid and tripalmitin react to produce 1, 3-dioleoyl-2-palmitoyl triglyceride. The method has the advantages of stable raw material source, low cost, stable and excellent product quality and the like.

Description

technical field [0001] The invention relates to a method for preparing an organic compound, in particular to a method for preparing 1,3-dioleic acid-2-palmitic acid triglyceride from palm oil. Background technique [0002] At present, human milk fat is recognized as the best food for infants and young children. After birth, the baby must take in the nutrients suitable for its own growth and development, so as to ensure the normal growth and development of its body. Natural breast milk fat has its own unique structural characteristics. The saturated fatty acid (palmitic acid) in breast milk fat contains about 25% mass fraction in the total fatty acid composition of triglycerides, and is mainly distributed in the middle position of the glycerol skeleton of triglycerides , that is, the Sn-2 position, whose distribution rate reaches 65%-70%, to ensure a high absorption effect of fatty acids and minerals, and provide about 10% of energy for the growth and normal physiological ac...

Claims

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Application Information

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IPC IPC(8): C12P7/64
CPCC12P7/6472
Inventor 邓利聂开立
Owner CHANGZHOU JUNSHI BIOTECH
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