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Spinal implantation unit and preparation method thereof

A spine and medicine technology, applied in the field of spine implantation unit and its preparation, can solve the problems of drug action discount and the like, and achieve the effects of simple manufacturing method, stable chemical properties, good penetration and permeability

Active Publication Date: 2015-05-06
SUZHOU MINIMALLY INVASIVE SPINAL TRAUMA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] It can be seen that in the prior art, various treatments are carried out on the surface of the implant, such as drug coating, copper ion infiltration, anodic oxidation surface modification treatment technology and other methods to achieve the purpose of antibacterial, but the drug layer is very thin, and the drug release is limited. Naturally, the time is short, and if you want to maintain the drug effect for about one year, you will not be able to achieve it
In addition, because these implants have a lot of friction with bone tissue and instruments during the implantation process, there may not be much drug left after the screw enters the bone, and the drug effect will be greatly reduced

Method used

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  • Spinal implantation unit and preparation method thereof
  • Spinal implantation unit and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] After the dynamic rod is machined, use an ultrasonic cleaning machine to clean the oil, and then use an ultrasonic cleaning machine for final cleaning and drying in a 100,000-class purification workshop. dynamic stick figure 1 shown.

[0047] Select the liquid silicone rubber that can be implanted for a long time, first add the drug (clonidine) into the liquid silicone rubber and mix well, then add the curing agent (0.5wt%) matched with the liquid silicone rubber, and mix well to form a drug-containing The liquid silicone rubber with curing agent is transferred into the syringe and then injected into the spiral groove of the dynamic rod. Curing at room temperature for 24 hours. The shape of the cured silicone rubber body loaded with drugs is as follows: figure 2 Shown, where the thickness B is 3mm.

[0048] Liquid silicone rubber: drug: curing agent = 100:30:0.5 (weight ratio).

[0049] The daily drug release rate is controlled at less than 100 μg / kg (patient body...

Embodiment 2

[0051] Same as Example 1, except that α-adrenaline is selected as the drug and the thickness B is 2 mm. The dynamic rod is implanted near the intervertebral disc to share the activity and stress function of the intervertebral disc and prevent further degeneration of the intervertebral disc. Dynamic sticks carry alpha-adrenaline, which can treat degenerative disc disease including herniated discs.

Embodiment 3

[0053] Same as Example 1, except that liquid silicone rubber containing medicine and curing agent is injected into the through hole in the middle of the dynamic rod, the weight ratio of medicine to liquid silicone rubber is 40%, and the thickness is 5mm. Liquid silicone rubber containing drug and curing agent is injected into the through hole, which can increase the drug loading and release the drug for as long as one year.

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Abstract

Disclosed is a spine implant unit, comprising an elastic segment, wherein the elastic segment contains a silicone rubber loaded with a drug. Also disclosed is a method for preparing a spine implant unit, comprising the following operation steps: providing a spine implant unit, wherein the spine implant unit comprises an elastic segment; washing and drying the spine implant unit; and injecting liquid silicone rubber containing a drug and a curing agent into the elastic segment, curing at room temperature and forming a silicone rubber loaded with the drug. The spine implant unit has the following functions: relieving pain persistent ailment caused by adhesion and oppression of a focal point, clearing cartilage calcification to break down and absorb same and clearing edema and hypertrophy of yellow ligament and posterior longitudinal ligament.

Description

technical field [0001] The invention relates to the field of medical instruments. Specifically, the present invention applies to the field of orthopedic spinal internal fixation, and relates to a spinal implant unit and a preparation method thereof. Background technique [0002] The oppression caused by adhesions before and after orthopedic surgery is a big problem that bothers doctors and affects the success rate of surgery. The adhesion phenomenon before the operation brings difficulty and risk to the operation, and the adhesion phenomenon after the operation causes the failure of the operation and increases the possibility of the second operation. At the same time, when the orthopedic implant needs to be removed to complete its mission, the risk of surgery will also increase. Adhesion symptoms can be reduced or eliminated if the implant is loaded with anti-inflammatory drugs and released slowly to inhibit them. [0003] The compression caused by cartilage calcification...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/70
CPCA61B17/7097A61B17/7019A61B17/7031
Inventor 田芳高耀平林忠陈伟张静
Owner SUZHOU MINIMALLY INVASIVE SPINAL TRAUMA MEDICAL TECH CO LTD
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